Výsledky vyhledávání - "Andrew J, Doig"

Akademický článek

Essentiality, protein–protein interactions and evolutionary properties are key predictors for identifying cancer-associated genes using machine learning

Autor: Amro Safadi, Simon C. Lovell, Andrew J. Doig

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract The distinctive nature of cancer as a disease prompts an exploration of the special characteristics the genes implicated in cancer exhibit. The identification of cancer-associated genes and their characteristics is crucial to further our und

Externí odkaz: https://doaj.org/article/14f4cef99e4d4d77b6256feb6099852e

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Akademický článek

Predicting congenital renal tract malformation genes using machine learning

Autor: Mitra Kabir, Helen M. Stuart, Filipa M. Lopes, Elisavet Fotiou, Bernard Keavney, Andrew J. Doig, Adrian S. Woolf, Kathryn E. Hentges

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Congenital renal tract malformations (RTMs) are the major cause of severe kidney failure in children. Studies to date have identified defined genetic causes for only a minority of human RTMs. While some RTMs may be caused by poorly defined e

Externí odkaz: https://doaj.org/article/f53fdbd76f954105b41d5e7e7e993256

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Akademický článek

Identifying mouse developmental essential genes using machine learning

Autor: David Tian, Stephanie Wenlock, Mitra Kabir, George Tzotzos, Andrew J. Doig, Kathryn E. Hentges

Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 12 (2018)

The genes that are required for organismal survival are annotated as ‘essential genes’. Identifying all the essential genes of an animal species can reveal critical functions that are needed during the development of the organism. To inform studi

Externí odkaz: https://doaj.org/article/9d2b781b5b6349da9d6c5618ef027fce

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Akademický článek

Properties of genes essential for mouse development.

Autor: Mitra Kabir, Ana Barradas, George T Tzotzos, Kathryn E Hentges, Andrew J Doig

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0178273 (2017)

Essential genes are those that are critical for life. In the specific case of the mouse, they are the set of genes whose deletion means that a mouse is unable to survive after birth. As such, they are the key minimal set of genes needed for all the s

Externí odkaz: https://doaj.org/article/338142c138c940b5a0c39f713a8b75e6

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Akademický článek

Properties of protein drug target classes.

Autor: Simon C Bull, Andrew J Doig

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0117955 (2015)

Accurate identification of drug targets is a crucial part of any drug development program. We mined the human proteome to discover properties of proteins that may be important in determining their suitability for pharmaceutical modulation. Data was g

Externí odkaz: https://doaj.org/article/8918f8001daa48df98ff6b74583efa20

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Essentiality, Protein-Protein Interactions and Evolutionary Properties are Key Predictors for Identifying Cancer Genes Using Machine Learning

Autor: Andrew J. Doig, Simon C. Lovell, Amro Safadi

The identification of genes that may be linked to cancer is of great importance for the discovery of new drug targets. The rate at which cancer genes are being found experimentally is slow, however, due to the complexity of the identification and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc2150497916066025812e16037a5a07
https://doi.org/10.1101/2021.09.01.458494

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Viral Involvement in Alzheimer’s Disease

Autor: Ahmad Sait, Andrew J. Doig, Philip J. R. Day, Cristian Angeli

Publikováno v: Sait, A, Angeli, C, Doig, A J & Day, P J R 2021, ' Viral Involvement in Alzheimer’s Disease ', ACS Chemical Neuroscience . https://doi.org/10.1021/acschemneuro.0c00719
ACS Chemical Neuroscience

Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is expected to reach 141 million cases by 2050. Despite the risk fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9333c2f3cbc161b071779b4b9a7357b0
https://doi.org/10.1021/acschemneuro.0c00719

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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

Publikováno v: Chemical Reviews
Chemical Reviews, American Chemical Society, 2021
Chemical Reviews, American Chemical Society, 2021, 121 (4), pp.2545-2647. ⟨10.1021/acs.chemrev.0c01122⟩
Chemical reviews (2021): 2545–2647. doi:10.1021/acs.chemrev.0c01122
info:cnr-pdr/source/autori:Nguyen P.H.; Ramamoorthy A.; Sahoo B.R.; Zheng J.; Faller P.; Straub J.E.; Dominguez L.; Shea J.-E.; Dokholyan N.V.; De Simone A.; Ma B.; Nussinov R.; Najafi S.; Ngo S.T.; Loquet A.; Chiricotto M.; Ganguly P.; McCarty J.; Li M.S.; Hall C.; Wang Y.; Miller Y.; Melchionna S.; Habenstein B.; Timr S.; Chen J.; Hnath B.; Strodel B.; Kayed R.; Lesne S.; Wei G.; Sterpone F.; Doig A.J.; Derreumaux P./titolo:Amyloid Oligomers: A Joint Experimental%2FComputational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis/doi:10.1021%2Facs.chemrev.0c01122/rivista:Chemical reviews/anno:2021/pagina_da:2545/pagina_a:2647/intervallo_pagine:2545–2647/volume
Chemical reviews 121(4), 2545-2647 (2021). doi:10.1021/acs.chemrev.0c01122
Chem Rev

International audience; Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bcb0310fc32a8257da65e0ea9a275e
http://hdl.handle.net/11588/839306

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Glycine rich segments adopt polyproline II helices: Implications for biomolecular condensate formation

Autor: Miguel Mompeán, Eurico J. Cabrita, S.S. Félix, Andrew J. Doig, Miguel A. Treviño, R. López-Sánchez, David Pantoja-Uceda, Javier Oroz, Bethan S. McAvan, Douglas V. Laurents

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Supplementary data related to this article can be found at https://doi.org/10.1016/j.abb.2021.108867.
Many intrinsically disordered proteins contain Gly-rich regions which are generally assumed to be disordered. Such regions often form biomolecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2cd528d87d9cc3bf0eb95731d49b34
http://hdl.handle.net/10261/260140

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Akademický článek

Maximising the size of non-redundant protein datasets using graph theory.

Autor: Simon C Bull, Mark R Muldoon, Andrew J Doig

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55484 (2013)

Analysis of protein data sets often requires prior removal of redundancy, so that data is not biased by containing similar proteins. This is usually achieved by pairwise comparison of sequences, followed by purging so that no two pairs have similarit

Externí odkaz: https://doaj.org/article/b93baa2211e6468693bab1771e0bd15e

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