Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Andrew I. Flyak"'
Autor:
Nina G. Bozhanova, Andrew I. Flyak, Benjamin P. Brown, Stormy E. Ruiz, Jordan Salas, Semi Rho, Robin G. Bombardi, Luke Myers, Cinque Soto, Justin R. Bailey, James E. Crowe, Pamela J. Bjorkman, Jens Meiler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Identifying determinants of broadly neutralizing antibodies against hepatitis C virus (HCV) may guide HCV vaccine design. Here, the authors discover new anti-HCV antibodies using computational screening and analyze the amino acid composition and sequ
Externí odkaz:
https://doaj.org/article/f9573f4cd2774fcb9a4cbb1c42411547
Autor:
Nicole Frumento, Alexis Figueroa, Tingchang Wang, Muhammad N. Zahid, Shuyi Wang, Guido Massaccesi, Georgia Stavrakis, James E. Crowe Jr, Andrew I. Flyak, Hongkai Ji, Stuart C. Ray, George M. Shaw, Andrea L. Cox, Justin R. Bailey
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
A prophylactic hepatitis C virus (HCV) vaccine that elicits neutralizing antibodies could be key to HCV eradication. However, the genetic and antigenic properties of HCV envelope (E1E2) proteins capable of inducing anti-HCV broadly neutralizing antib
Externí odkaz:
https://doaj.org/article/596058b1e58e410a97427a1e7246375a
Autor:
Charles D. Murin, Pavlo Gilchuk, Philipp A. Ilinykh, Kai Huang, Natalia Kuzmina, Xiaoli Shen, Jessica F. Bruhn, Aubrey L. Bryan, Edgar Davidson, Benjamin J. Doranz, Lauren E. Williamson, Jeffrey Copps, Tanwee Alkutkar, Andrew I. Flyak, Alexander Bukreyev, James E. Crowe, Jr., Andrew B. Ward
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108984- (2021)
Summary: Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be broadly neutralizing, but the details of their epitopes and basis for neutralization
Externí odkaz:
https://doaj.org/article/165fbb29f604470fb6b0a404b517d2da
Autor:
Natalia A. Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo I. Santos, Andrew I. Flyak, Philipp A. Ilinykh, Kai Huang, Ndongala M. Lubaki, Palaniappan Ramanathan, James E. Crowe, Jr., Alexander Bukreyev
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1802-1815.e5 (2018)
Summary: Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can protect against infection. It is currently unknown whether natural infection also induces some antibodies with the capacity for antibody-dependent enhance
Externí odkaz:
https://doaj.org/article/7731be7a37cd40b998e7c2e9e58cefde
Autor:
Zachary A. Bornholdt, Esther Ndungo, Marnie L. Fusco, Shridhar Bale, Andrew I. Flyak, James E. Crowe, Kartik Chandran, Erica Ollmann Saphire
Publikováno v:
mBio, Vol 7, Iss 1 (2016)
ABSTRACT The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immu
Externí odkaz:
https://doaj.org/article/a52569eeff68458194119235d34d17bb
Autor:
Michel C. Nussenzweig, Shurong Hou, Pamela J. Bjorkman, Victor A. Ramos, Paul D. Bieniasz, Alice Cho, Theodora Hatziioannou, Kathryn E. Huey-Tubman, Magdalena Rutkowska, Christian Gaebler, Thiago Y. Oliveira, Frauke Muecksch, Zijun Wang, Marina Caskey, Anna Gazumyan, Celia A. Schiffer, Yiska Weisblum, Andrew I. Flyak, Melissa Cipolla, Justin Da Silva, Daniel Poston, Andrew T. DeLaitsch, Fabian Schmidt, Shlomo Finkin, Julio C. C. Lorenzi, Dennis Schaefer-Babajew, Christopher O. Barnes, Katrina G. Millard
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Spike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3040289ef46e509fc1d3be914b443f8d
https://resolver.caltech.edu/CaltechAUTHORS:20210802-161329765
https://resolver.caltech.edu/CaltechAUTHORS:20210802-161329765
Publikováno v:
Curr Opin Virol
Broadly neutralizing antibodies (bNAbs) block infection by genetically diverse hepatitis C virus (HCV) isolates by targeting relatively conserved epitopes on the HCV envelope glycoproteins, E1 and E2. Many amino acid substitutions conferring resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee21c3dfb219887211ac7e9c6f583b5
https://europepmc.org/articles/PMC8500940/
https://europepmc.org/articles/PMC8500940/
Autor:
Madeleine C. Mankowski, Andrea L. Cox, Andrew I. Flyak, Guido Massaccesi, Stuart C. Ray, Justin R. Bailey, Michelle D. Colbert, William O. Osburn, Valerie J. Kinchen, James E. Crowe
Publikováno v:
Journal of Clinical Investigation. 129:4786-4796
A vaccine for hepatitis C virus (HCV) is urgently needed. Development of broadly neutralizing plasma antibodies during acute infection is associated with HCV clearance, but the viral epitopes of these plasma antibodies are unknown. Identifying these
Autor:
Philipp A. Ilinykh, James E. Crowe, Xiaoli Shen, Alexander Bukreyev, Andrew I. Flyak, Pavlo Gilchuk, Charles D. Murin, Jessica F. Bruhn, Lauren E. Williamson, Aubrey L. Bryan, Jeffrey Copps, Andrew B. Ward, Tanwee Alkutkar, Natalia Kuzmina, Benjamin J. Doranz, Edgar Davidson, Kai Huang
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108984-(2021)
Cell reports
Cell reports
SUMMARY Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be broadly neutralizing, but the details of their epitopes and basis for neutralization a
Autor:
Kathryn E. Huey-Tubman, Andrew I. Flyak, Magdalena Rutkowska, Thiago Y. Oliveira, Anna Gazumyan, Zijun Wang, Marina Caskey, Celia A. Schiffer, Yiska Weisblum, Julio C. C. Lorenzi, Christian Gaebler, Shlomo Finkin, Victor A. Ramos, Paul D. Bieniasz, Frauke Muecksch, Michel C. Nussenzweig, Pamela J. Bjorkman, Fabian Schmidt, Dennis Schaefer-Babajew, Alice Cho, Christopher O. Barnes, Katrina G. Millard, Melissa Cipolla, Theodora Hatziioannou, Justin Da Silva, Daniel Poston, Andrew T. DeLaitsch, Shurong Hou
Publikováno v:
Immunity
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Spike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb5ac12380ac501fc4c33d534317220
https://doi.org/10.1101/2021.03.07.434227
https://doi.org/10.1101/2021.03.07.434227