Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Andrew Hollands"'
Autor:
Leo Lin, Poochit Nonejuie, Jason Munguia, Andrew Hollands, Joshua Olson, Quang Dam, Monika Kumaraswamy, Heriberto Rivera Jr., Ross Corriden, Manfred Rohde, Mary E. Hensler, Michael D. Burkart, Joe Pogliano, George Sakoulas, Victor Nizet
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 690-698 (2015)
Antibiotic resistance poses an increasingly grave threat to the public health. Of pressing concern, rapid spread of carbapenem-resistance among multidrug-resistant (MDR) Gram-negative rods (GNR) is associated with few treatment options and high morta
Externí odkaz:
https://doaj.org/article/e18293e0ce8842e89a217c56927c7952
Autor:
Annabel Guichard, Prashant Jain, Mahtab Moayeri, Ruth Schwartz, Stephen Chin, Lin Zhu, Beatriz Cruz-Moreno, Janet Z Liu, Bernice Aguilar, Andrew Hollands, Stephen H Leppla, Victor Nizet, Ethan Bier
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006603 (2017)
Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As
Externí odkaz:
https://doaj.org/article/7da69dcd7e13456c9f96af4371105fec
Autor:
Ann E. Lin, Federico C. Beasley, Nadia Keller, Andrew Hollands, Rodolfo Urbano, Emily R. Troemel, Hal M. Hoffman, Victor Nizet
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT The M1T1 clone of group A Streptococcus (GAS) is associated with severe invasive infections, including necrotizing fasciitis and septicemia. During invasive M1T1 GAS disease, mutations in the covRS regulatory system led to upregulation of an
Externí odkaz:
https://doaj.org/article/1ae0b0c745294a0da11db658350bbcde
Autor:
Martina L Sanderson-Smith, Yueling Zhang, Diane Ly, Deborah Donahue, Andrew Hollands, Victor Nizet, Marie Ranson, Victoria A Ploplis, Mark J Walker, Francis J Castellino
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003469 (2013)
Recruitment of the serine protease plasmin is central to the pathogenesis of many bacterial species, including Group A streptococcus (GAS), a leading cause of morbidity and mortality globally. A key process in invasive GAS disease is the ability to a
Externí odkaz:
https://doaj.org/article/fca5dc76a6ce464cbcffb989cb933e88
Autor:
Jason N. Cole, Morgan A. Pence, Maren von Köckritz-Blickwede, Andrew Hollands, Richard L. Gallo, Mark J. Walker, Victor Nizet
Publikováno v:
mBio, Vol 1, Iss 4 (2010)
ABSTRACT The initiation of hyperinvasive disease in group A Streptococcus (GAS) serotype M1T1 occurs by mutation within the covRS two-component regulon (named covRS for control of virulence regulatory sensor kinase), which promotes resistance to neut
Externí odkaz:
https://doaj.org/article/29d2718b948441769760790a55214328
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4102 (2008)
Epidemiological studies of group A streptococcus (GAS) have noted an inverse relationship between SpeB expression and invasive disease. However, the role of SpeB in the course of infection is still unclear. In this study we utilize a SpeB-negative M1
Externí odkaz:
https://doaj.org/article/0cf45c536c8b4694a5d6416c58b1440b
Autor:
Bipin G. Nair, Samira Dahesh, Ann Lin, Alexandra C. Newton, Geetha B. Kumar, J. Jefferson P. Perry, Maya T. Kunkel, Ross Corriden, Syed Raza Ali, Gabriela Gysler, Victor Nizet, Joshua Olson, Stefano Forli, Andrew Hollands
Publikováno v:
Journal of Biological Chemistry. 291:13964-13973
Emerging antibiotic resistance among pathogenic bacteria is an issue of great clinical importance, and new approaches to therapy are urgently needed. Anacardic acid, the primary active component of cashew nut shell extract, is a natural product used
Autor:
Vishal Patel, Thomas F. Gallegos, Andrew Hollands, Roman Sasik, Gary Hardiman, Victor Nizet, Salah A. Mohamed, Vishal Nigam, Charles C. King, Andrew Hinton, Katrina Carrion, Jeffrey Dyo, Emma Leire, Sanjay K. Nigam
Publikováno v:
The FASEB Journal. 29:1859-1868
Bicuspid aortic valves calcify at a significantly higher rate than normal aortic valves, a process that involves increased inflammation. Because we have previously found that bicuspid aortic valve experience greater stretch, we investigated the poten
Autor:
Stephen H. Leppla, Andrew Hollands, Stephen Chin, Ethan Bier, Beatriz Cruz-Moreno, Ruth Schwartz, Prashant Jain, Janet Z. Liu, Bernice Aguilar, Victor Nizet, Mahtab Moayeri, Lin Zhu, Annabel Guichard
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 9, p e1006603 (2017)
PLoS Pathogens, Vol 13, Iss 9, p e1006603 (2017)
Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As
Autor:
Annelies S. Zinkernagel, Andrew Hollands, Nadia Keller, Reto A. Schuepbach, Ewerton Marques Maggio, Federica Andreoni, Victor Nizet, Andrina Neff, Fabio Ugolini
Publikováno v:
The Journal of Infectious Diseases
A clinicalStreptococcus dysgalactiae equisimilis strain secreting high levels of streptokinase promoted severe disease in a patient lacking anti-streptokinase antibodies. Exogenous immunoglobulins efficiently blocked streptokinase-mediated fibrinolys