Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrew Hofacre"'
Autor:
Amy H. Lin, Christopher G. Twitty, Ryan Burnett, Andrew Hofacre, Leah A. Mitchell, Fernando Lopez Espinoza, Harry E. Gruber, Douglas J. Jolly
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 221-232 (2017)
Tumor cells express a number of immunosuppressive molecules that can suppress anti-tumor immune responses. Efficient delivery of small interfering RNAs to treat a wide range of diseases including cancers remains a challenge. Retroviral replicating ve
Externí odkaz:
https://doaj.org/article/7862354fc3bd49d99e2426c4a22b63fb
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005241 (2017)
While virus growth dynamics have been well-characterized in several infections, data are typically collected once the virus population becomes easily detectable. Earlier dynamics, however, remain less understood. We recently reported unusual early dy
Externí odkaz:
https://doaj.org/article/44c659b7f6c9492ea0249dd794284d72
Autor:
Andrew Hofacre, Hung Fan
Publikováno v:
Viruses, Vol 2, Iss 12, Pp 2618-2648 (2010)
Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a lung cancer in sheep known as ovine pulmonary adenocarcinoma (OPA). The disease has been identified around the world in several breeds of sheep and goats, and JSRV infection typically has
Externí odkaz:
https://doaj.org/article/f2d84830a41b4b13908cbb32c07190b6
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002547 (2012)
Oncolytic viruses replicate selectively in tumor cells and can serve as targeted treatment agents. While promising results have been observed in clinical trials, consistent success of therapy remains elusive. The dynamics of virus spread through tumo
Externí odkaz:
https://doaj.org/article/1cd547f4c2a242e5b2baab720486b3f6
Autor:
Anthony W. Munday, William P. Accomando, Cynthia Burrascano, Sophie Viaud, Daniel Mendoza, Marin V. Miner, Kader Yagiz, Leah Mitchell, Ali Haghighi, Amy H. Lin, Dawn Gammon, Harry E. Gruber, Douglas J. Jolly, Fernando Lopez Espinoza, Simon Bergqvist, Maria Rodriguez-Aguirre, Andrew Hofacre
Publikováno v:
Oncotarget
Immune checkpoint inhibitors (CPIs) are associated with a number of immune-related adverse events and low response rates. We provide preclinical evidence for use of a retroviral replicating vector (RRV) selective to cancer cells, to deliver CPI agent
Autor:
Andrew Hofacre, Harry E. Gruber, Ryan Burnett, Douglas J. Jolly, Fernando Lopez Espinoza, Leah Mitchell, Amy H. Lin, Christopher G. Twitty
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss, Pp 221-232 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Tumor cells express a number of immunosuppressive molecules that can suppress anti-tumor immune responses. Efficient delivery of small interfering RNAs to treat a wide range of diseases including cancers remains a challenge. Retroviral replicating ve
Autor:
Harry E. Gruber, Amy Lin, Cynthia Burrascano, Fernando Lopez Espinoza, Andrew Hofacre, Daniel Mendoza, Anthony W. Munday, Leah Mitchell, Kader Yagiz, Douglas J. Jolly
Publikováno v:
Neuro-Oncology. 20:vi280-vi280
Conventional interventions for treating glioblastoma (GBM) patients has had limited success, with a median overall survival of 15–17 months. Recently, immune checkpoint inhibitors (CPIs) showed long-term response rates from 20–30% in some tumors,
Autor:
Hung Fan, Andrew Hofacre
Publikováno v:
Viruses, Vol 2, Iss 12, Pp 2618-2648 (2010)
Viruses
Hofacre, Andrew; & Fan, Hung. (2010). Jaagsiekte Sheep Retrovirus Biology and Oncogenesis. Viruses, 2(12), 2618-2648. doi: 10.3390/v2122618. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1r6640b5
Viruses
Hofacre, Andrew; & Fan, Hung. (2010). Jaagsiekte Sheep Retrovirus Biology and Oncogenesis. Viruses, 2(12), 2618-2648. doi: 10.3390/v2122618. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1r6640b5
Jaagsiekte sheep retrovirus (JSRV) is the causative agent of a lung cancer in sheep known as ovine pulmonary adenocarcinoma (OPA). The disease has been identified around the world in several breeds of sheep and goats, and JSRV infection typically has
Autor:
Hung Fan, Andrew Hofacre
Publikováno v:
Journal of Virology. 78:10479-10489
Jaagsiekte sheep retrovirus (JSRV) is an exogenous retrovirus of sheep that induces a contagious lung cancer, ovine pulmonary adenocarcinoma. We previously showed that the gene encoding JSRV envelope protein (Env) appears to function as an oncogene,
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 1, p e1005241 (2017)
PLoS computational biology, vol 13, iss 1
PLoS Computational Biology, Vol 13, Iss 1, p e1005241 (2017)
PLoS computational biology, vol 13, iss 1
While virus growth dynamics have been well-characterized in several infections, data are typically collected once the virus population becomes easily detectable. Earlier dynamics, however, remain less understood. We recently reported unusual early dy