Significance of NPM1 Gene Mutations in AML

Autor: Andrew Hindley, Mark Alexander Catherwood, Mary Frances McMullin, Ken I. Mills

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 18, p 10040 (2021)

The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly wit

Externí odkaz: https://doaj.org/article/d371a48c7ef041d49a908f726f169955

Mutational profiling in suspected triple-negative essential thrombocythaemia using targeted next-generation sequencing in a real-world cohort

Autor: Mary Frances McMullin, Patrick McCallion, Roisin McAllister, Robert J. G. Cuthbert, Julie McGimpsey, Andrew Hindley, Olga Michail, Nicholas C.P. Cross, Graeme Greenfield, John Feerick, Claire Arnold, Mark Catherwood

Publikováno v: Michail, O, McCallion, P, McGimpsey, J, Hindley, A, Greenfield, G, Feerick, J, Arnold, C, Cross, N, Cuthbert, R, McMullin, M F & Catherwood, M A 2020, ' Mutational profiling in suspected triple-negative essential thrombocythaemia using targeted next-generation sequencing in a real-world cohort ', Journal of Clinical Pathology . https://doi.org/10.1136/jclinpath-2020-206570

Essential thrombocythaemia (ET) is driven by somatic mutations involving the JAK2, CALR and MPL genes. Approximately 10% of patients lack driver mutations and are referred as ‘triple-negative’ ET (TN-ET). The diagnosis of TN-ET, however, relies o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366eccd761cc2ee2f1507e66fd2cce27
https://pure.qub.ac.uk/en/publications/mutational-profiling-in-suspected-triplenegative-essential-thrombocythaemia-using-targeted-nextgeneration-sequencing-in-a-realworld-cohort(19570fa7-5833-4742-ade0-a2c0e529570f).html

Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials

Autor: Ignace Vergote, Corneel Coens, Matthew Nankivell, Gunnar B Kristensen, Mahesh K B Parmar, Tom Ehlen, Gordon C Jayson, Nick Johnson, Ann Marie Swart, René Verheijen, W Glenn McCluggage, Tim Perren, Pierluigi Benedetti Panici, Gemma Kenter, Antonio Casado, Cesar Mendiola, Gavin Stuart, Nick S Reed, Sean Kehoe, Claes Tropé G., Stephen Dobbs, Sharadah Essapen, P. Hoskins, John Green, E. Gilby, M. Van Baal, Jeremy Twigg, Maria E.L. Van Der Burg, Keith Godfrey, Angel J. Lacave, R. Angioli, Rahul Nath, Kirk Chin, Charles Redman, R. Lotocki, Adeola Olaitan, B. Mosgaard, G. Rustin, Thomas Ind, Mojca Persic, Martin Hogg, J. Van Der Velden, J. Ledermann, Peter Sykes Peter Sykes, Krishnawam Madhavan, P. Kannisto, Vicky Hird, A. Evans, R. Sandvei R., P. Gauthier, D.J. Cruickshank, P.B. Ottevanger, Sheila Pearson, Henry Kitchener, Marcia Hall, P. Bessette, S. Pecorelli, E. Gerdin, Tito Lopes, Andrew Fish, Clare Barlow., K. Van Eygen, A. Floquet, B. Tholander, N. Gul, Robert Gornall, David Luesley, Philip Kirwan, Paul Symonds, Richard Henry, David Poole, Ian McNeish, Mark Hocking, Al Sammaraie, P. Speiser, E. Leblanc, J.A. Green, C.F. De Oliveira, R. Grimshaw, P. Zola, David Parkin, Martin Lamb, Anne Hong, Alan Gillespie, Abdel Hamid, Ahmed Ahmed, M. Plante, B. De Valk, A. Nordin, Andrew Clamp, David Perez, Graham Dark Graham Dark, Michelle Ferguson, Carol MacGregor, Geraldine Skailes, Rachel Jones, G. Cawdell, Simon Leeson, L. Elit, C. Dittrich, W. Gotlieb, John Cullimore, Barbara Crosse, Paul Ridley, Anthony Head, Joaquin Nieto, Saif Awwad, Dirk Brinkmann, Damian Eustace, Andrew Hindley, D. Katsaros, C. Popadiuk, Tome Kristeller, C. Redman, S. Chan, C. Marth, Dennis Yiannakis, Kate Lankaster, Gareth Beynon, Anwar Suhail, Fernando Indrajit, Mary Quigley, Olu Adeyemi, Fiona Lofts, Orla McNally, Amanda Tristam, Martin Lee, R. Counsell, N. Gleeson, A. Papadopoulos, T. Maggino, A. Honkoop, P. Ghatage, J.B. Vermorken, J. De Greve, K. Boman, E Petru, F. Amant

Publikováno v: Lancet Oncology, 19, 12, pp. 1680-1687
Obstetrical and Gynecological Survey, 74(3), 156-158. Lippincott Williams and Wilkins
MRC CHORUS study investigators 2018, ' Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials ', The Lancet Oncology, vol. 19, no. 12, pp. 1680-1687 . https://doi.org/10.1016/S1470-2045(18)30566-7
Vergote, I, Coens, C, Nankivell, M, Kristensen, G B, Parmar, M K B, Ehlen, T, Jayson, G C, Johnson, N, Swart, A M, Verheijen, R, McCluggage, W G, Perren, T, Panici, P B, Kenter, G, Casado, A, Mendiola, C, Stuart, G, Reed, N S & Kehoe, S 2019, ' Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: Pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials ', Obstetrical and Gynecological Survey, vol. 74, no. 3, pp. 156-158 . https://doi.org/10.1097/01.ogx.0000554460.78765.59
Jayson, G 2018, ' Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials. ', Lancet Oncology, vol. 19, no. 12, pp. 1680-1687 . https://doi.org/10.1016/S1470-2045(18)30566-7
Lancet Oncology, 19, 1680-1687
The Lancet Oncology, 19(12), 1680-1687. Lancet Publishing Group

Summary Background Individual patient data from two randomised trials comparing neoadjuvant chemotherapy with upfront debulking surgery in advanced tubo-ovarian cancer were analysed to examine long-term outcomes for patients and to identify any prefe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32bf7e089ed9921db1ad91c3ad4e088
https://hdl.handle.net/2066/200265

Mometasone furoate cream reduces acute radiation dermatitis in patients receiving breast radiation therapy: results of a randomized trial

Autor: Anne Whitehead, Ruth Hornsby, David Charles Barber, Zakiyah Zain, Alison Sanneh, Andrew Hindley, Lisa Wood

Publikováno v: International journal of radiation oncology, biology, physics. 90(4)

Purpose We wanted to confirm the benefit of mometasone furoate (MF) in preventing acute radiation reactions, as shown in a previous study (Bostrom et al, Radiother Oncol 2001;59:257-265). Methods and Materials The study was a double-blind comparison

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197bad69042cb1d039aa7e7d005feab2
https://pubmed.ncbi.nlm.nih.gov/25752410

Quality assurance audit in an Australasian phase III trial of accelerated radiotherapy for head and neck cancer (TROG 91.01)

Autor: Andrew Hindley, Lester J. Peters, H. Krawitz, David Lamb, James W. Denham, Michael Poulsen, Christopher S. Hamilton, Quenten Walker, Allison Steigler, N. Spry

Publikováno v: Australasian Radiology. 43:227-232

The Trans-Tasman Radiation Oncology Group (TROG) initiated a randomized trial, testing accelerated (twice daily) radiotherapy against conventional radiotherapy for stage III and stage IV squamous cell carcinoma of the head and neck in 1991. In 1996,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05b7529b92d8bfba52526e3b1890e12b
https://doi.org/10.1046/j.1440-1673.1999.00639.x