Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Andrew Hiatt"'
Autor:
Alena V Savonenko, Tatiana Melnikova, Yuchuan Wang, Hayden Ravert, Yongjun Gao, Jeremy Koppel, Deidre Lee, Olga Pletnikova, Eugenia Cho, Nuzhat Sayyida, Andrew Hiatt, Juan Troncoso, Peter Davies, Robert F Dannals, Martin G Pomper, Andrew G Horti
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129618 (2015)
In Alzheimer's disease (AD), one of the early responses to Aβ amyloidosis is recruitment of microglia to areas of new plaque. Microglial receptors such as cannabinoid receptor 2 (CB2) might be a suitable target for development of PET radiotracers th
Externí odkaz:
https://doaj.org/article/ff75184c9dbf46579049ab1c4c10b095
Publikováno v:
Clinical and Developmental Immunology, Vol 2013 (2013)
Vaccination strategies depend entirely on the appropriate responsiveness of our immune system against particular antigens. For this active immunization to be truly effective, neutralizing antibodies (nAbs) need to efficiently counter the infectivity
Externí odkaz:
https://doaj.org/article/11849b16346348bca4784be12e6ad6b4
Publikováno v:
Antiviral Discovery for Highly Pathogenic Emerging Viruses ISBN: 9781788015646
Drug Discovery
Drug Discovery
Antibodies play a critical role in the prevention and resolution of infectious diseases. This chapter focuses on the role of antibodies in filovirus infection and disease. Anti-filovirus antibodies are critical in overcoming filovirus infections as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca5bf66041fc4ea263820a207e9bf27
https://doi.org/10.1039/9781788016858-00091
https://doi.org/10.1039/9781788016858-00091
Autor:
Clemens Gruber, Herta Steinkellner, Karla A. Fenton, Sara Sahandi, M. Javad Aman, Natasha Bohorova, Delia Enria, Charles Goodman, Daniel J. Deer, Do Jin Kim, Xiaoguo Zhan, Jesus Velasco, Kevin J. Whaley, Anna N. Honko, Friedrich Altmann, Thomas W. Geisbert, Larry Zeitlin, Ana I. Kuehne, Joan B. Geisbert, Andrew Hiatt, Ognian Bohorov, Sven Enterlein, Michael H. Pauly
Publikováno v:
Proceedings of the National Academy of Sciences. 113:4458-4463
Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the improvement of global public health. Junin virus, the causative agent of Argentine hemorrhagic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ba89f5d3309cfda40c1a373df75bf1
https://doi.org/10.1073/pnas.1600996113
https://doi.org/10.1073/pnas.1600996113
Autor:
Andrew Hiatt, Kevin J. Whaley, Ognian Bohorov, Natasha Bohorova, Jesus Velasco, Do H. Kim, Thomas W. Geisbert, Viktoriya Borisevich, Krystle N. Agans, Chad E. Mire, Karla A. Fenton, Charles Goodman, Andrew I. Flyak, Joan B. Geisbert, Michael H. Pauly, James E. Crowe, Daniel J. Deer, Herta Steinkellner, Larry Zeitlin
Publikováno v:
Science Translational Medicine. 9
As observed during the 2013–2016 Ebola virus disease epidemic, containment of filovirus outbreaks is challenging and made more difficult by the lack of approved vaccine or therapeutic options. Marburg and Ravn viruses are highly virulent and cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1807c4d8fbaa62e6dc6cb34aa9b0b58
https://doi.org/10.1126/scitranslmed.aai8711
https://doi.org/10.1126/scitranslmed.aai8711
Autor:
Andrew Hiatt, Jesus Velasco, Natasha Bohorova, Brian E. Gilbert, Pedro A. Piedra, Do Jin Kim, Ognian Bohorov, Kevin J. Whaley, Michael H. Pauly, Charles Goodman, Larry Zeitlin
Publikováno v:
Proceedings of the National Academy of Sciences. 111:5992-5997
Respiratory syncytial virus (RSV) can cause devastating lower respiratory tract infections in preterm infants or when other serious health problems are present. Immunoprophylaxis with palivizumab (Synagis), a humanized IgG1 mAb, is the current standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3608686de9f37d7bdaf22923b511049
https://doi.org/10.1073/pnas.1402458111
https://doi.org/10.1073/pnas.1402458111
Autor:
Phil C. Wong, Tatiana Melnikova, Alena Savonenko, Juan C. Troncoso, Paul F. Worley, Donald L. Price, Tong Li, Andrew Hiatt
Publikováno v:
Neuropsychopharmacology. 37:261-277
Over the past three decades, significant progress has been made in understanding the neurobiology of Alzheimer's disease. In recent years, the first attempts to implement novel mechanism-based treatments brought rather disappointing results, with low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0609921f6f287e1d18a92c67e7ebeea0
https://doi.org/10.1038/npp.2011.211
https://doi.org/10.1038/npp.2011.211
Publikováno v:
Journal of Spacecraft and Rockets. 48:166-174
O PERATIONAL orbit determination and orbit prediction experience suggests that the extreme upper atmosphere is more variable than the factors included in atmospheric density models commonly used in orbit propagation. Unmodeled atmospheric density var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aef4e906e27834396b6afa7469bc1ad
https://doi.org/10.2514/1.47624
https://doi.org/10.2514/1.47624
Publikováno v:
Antibodies for Infectious Diseases
Numerous monoclonal antibodies (MAbs) that recognize and neutralize infectious pathogens have been isolated and developed over the years. The fact that infectious diseases can involve large populations of infected individuals is an important factor t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a48e9cdf1b2df0f117799f53ee4757b
https://pubmed.ncbi.nlm.nih.gov/26082108
https://pubmed.ncbi.nlm.nih.gov/26082108