Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Andrew H. Kang"'
Autor:
Linda K. Myers, Ying-Xin Ouyang, Jay R. Patel, Herman H. Odens, Virginia Woo-Rasberry, Jeoungeun Park, Ae-Kyung Yi, Edward F. Rosloniec, David D. Brand, John M. Stuart, Andrew H. Kang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9833
Citrullination of proteins plays an important role in protein function and it has recently become clear that citrullinated proteins play a role in immune responses. In this study we examined how citrullinated collagen, an extracellular matrix protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a6d452c104d758d70d71bbcd26f9fd
Autor:
David D. Brand, Jeoung-Eun Park, Linda K. Myers, Ae-Kyung Yi, John M. Stuart, Andrew H. Kang, Edward F. Rosloniec
Publikováno v:
J Biol Chem
Multiple observations implicate T-cell dysregulation as a central event in the pathogenesis of rheumatoid arthritis. Here, we investigated mechanisms for suppressing T-cell activation via the inhibitory receptor leukocyte-associated immunoglobulin-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e87508448649c646cb2472c778f56f
https://pubmed.ncbi.nlm.nih.gov/31932281
https://pubmed.ncbi.nlm.nih.gov/31932281
Autor:
Andrew H. Kang, David D. Brand, Jeoung-Eun Park, John M. Stuart, Edward F. Rosloniec, Linda K. Myers, Sirshendu Majumdar, Ae-Kyung Yi
The aim of this study was to understand how Syk affects peripheral T cell function. T cells from Syk (−/−) chimeric mice and DR1 Syk(fl/fl) CD4(cre) conditional mice gave strong CD3-induced Th1, Th2, and Th17 cytokine responses. However, an alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4d11db43ee6159de744f5718a3be3a
https://europepmc.org/articles/PMC6350940/
https://europepmc.org/articles/PMC6350940/
Autor:
Ae-Kyung Yi, David D. Brand, Linda K. Myers, John M. Stuart, Jeoung-Eun Park, David L. Cullins, Andrew H. Kang, Edward F. Rosloniec
Publikováno v:
Clinical Immunology. 160:188-197
Factors that drive T cells to signal through differing pathways remain unclear. We have shown that an altered peptide ligand (A9) activates T cells to utilize an alternate signaling pathway which is dependent upon FcRγ and Syk. However, it remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d536623bfd074c73ee5fdf552bf4bb
https://doi.org/10.1016/j.clim.2015.05.002
https://doi.org/10.1016/j.clim.2015.05.002
Autor:
Savannah L. Smith, Linda K. Myers, Seunghyun Kim, Edward F. Rosloniec, Lauren C. Price, David D. Brand, John M. Stuart, John E. Coligan, Andrew H. Kang, Jeoung-Eun Park, Ellis R. Easterling
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(8)
Several observations implicate a critical role for T cell dysregulation as a central problem in rheumatoid arthritis. We investigated a mechanism for suppressing T cell activation by stimulating a natural inhibitory receptor called leukocyte-associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76ee02b06be91df31c5d0cbd867f0e7
https://pubmed.ncbi.nlm.nih.gov/28887430
https://pubmed.ncbi.nlm.nih.gov/28887430
Autor:
Andrew H. Kang, David D. Brand, John M. Stuart, David L. Cullins, Jeoung-Eun Park, Jeffrey A. Rotondo, Ae-Kyung Yi, Linda K. Myers
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 197(12)
Rheumatoid arthritis is an autoimmune disorder characterized by T cell dysregulation. We have shown that an altered peptide ligand (A9) activates T cells to use an alternate signaling pathway that is dependent on FcRγ and spleen tyrosine kinase, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3f3d19ca3441746186d6397474545e
https://pubmed.ncbi.nlm.nih.gov/27837109
https://pubmed.ncbi.nlm.nih.gov/27837109
Autor:
Andrew H. Kang, Stacey Barnett, Linda K. Myers, John M. Stuart, Sandra Kleinau, Jeoung-Eun Park, Ae-Kyung Yi, Lillian Zalduondo, David L. Cullins
Publikováno v:
Journal of Biological Chemistry. 287:19765-19774
Mounting evidence from animal models has demonstrated that alterations in peptide-MHC interactions with the T cell receptor (TCR) can lead to dramatically different T cell outcomes. We have developed an altered peptide ligand of type II collagen, ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f2189c0faade4dbf156e4fabe0c89c
https://doi.org/10.1074/jbc.m112.349688
https://doi.org/10.1074/jbc.m112.349688
Autor:
David L. Cullins, Linda K. Myers, John M. Stuart, Andrew H. Kang, Sandra Kleinau, David D. Brand
Publikováno v:
Arthritis & Rheumatism. 63:2661-2670
Objective To explore the characteristics of the T cell population that responds to an analog peptide (A9) of type II collagen and regulates autoimmunity, using the collagen-induced arthritis (CIA) model. Methods Analog peptide A9 is a 26–amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c922d46ecf07b6300fdc35ec09c3856b
https://doi.org/10.1002/art.30454
https://doi.org/10.1002/art.30454
Autor:
David L. Cullins, Andrew H. Kang, John M. Stuart, Linda K. Myers, Ae-Kyung Yi, Jeoung-Eun Park, Jing Zhou, Bo Tang
Publikováno v:
Clinical Immunology. 133:145-153
We have previously described an analog peptide of type II collagen (CII) that can suppress collagen-induced arthritis (CIA). This analog peptide represents CII 245–270 , the immunodominant epitope of CII, but with substitutions at 260, 261, and 263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db19bd8eac941b7b3d8a133c2acad3e4
https://doi.org/10.1016/j.clim.2009.06.006
https://doi.org/10.1016/j.clim.2009.06.006
Autor:
Weikuan Gu, Andrew H. Kang, Arnold E. Postlethwaite, Qing Xiong, Karen A. Hasty, Yan Jiao, John M. Stuart
Publikováno v:
The Journal of Immunology. 181:859-864
Rheumatoid arthritis (RA) is an autoimmune disease, the pathogenesis of which is affected by multiple genetic and environmental factors. To understand the genetic and molecular basis of RA, a large number of quantitative trait loci (QTL) that regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84acaa0dcf63c2eee18ce908b12837db
https://doi.org/10.4049/jimmunol.181.2.859
https://doi.org/10.4049/jimmunol.181.2.859