Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Andrew H. A. Clayton"'
Publikováno v:
Molecules, Vol 29, Iss 12, p 2800 (2024)
The epidermal growth factor receptor (EGFR) is a pivotal target in cancer therapy due to its significance within the tyrosine kinase family. EGFR inhibitors like AG-1478 and PD153035, featuring a 4-anilinoquinazoline moiety, have garnered global atte
Externí odkaz:
https://doaj.org/article/94c87beba34d464499768e6a1a93beb6
Autor:
Tanja Pajić, Nataša V. Todorović, Miroslav Živić, Stanko N. Nikolić, Mihailo D. Rabasović, Andrew H. A. Clayton, Aleksandar J. Krmpot
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract We report the utilization of Third-Harmonic Generation microscopy for label-free live cell imaging of lipid droplets in the hypha of filamentous fungus Phycomyces blakesleeanus. THG microscopy images showed bright spherical features disperse
Externí odkaz:
https://doaj.org/article/1c6ef2eea29c48188acdb585a9e8f7a6
Publikováno v:
Biology, Vol 11, Iss 8, p 1135 (2022)
At present, about one-third of the total protein targets in the pharmaceutical research sector are kinase-based. While kinases have been attractive targets to combat many diseases, including cancer, selective kinase inhibition has been challenging, b
Externí odkaz:
https://doaj.org/article/96a713b9c4e94e3f917c8f69e9d8db3d
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Dacomitinib (PF-00299804) was recently approved by the Food and Drug Administration (FDA) as a tyrosine kinase inhibitor (TKI). Unfortunately, side effects and disease resistance eventually result from its use. Off-target effects in some kinase inhib
Externí odkaz:
https://doaj.org/article/43725824cb674410adae42c4704330fb
The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Autor:
Laura C. Zanetti-Domingues, Dimitrios Korovesis, Sarah R. Needham, Christopher J. Tynan, Shiori Sagawa, Selene K. Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C. Roovers, Alireza Lajevardipour, Paul M. P. van Bergen en Henegouwen, George Santis, Andrew H. A. Clayton, David T. Clarke, Francesco L. Gervasio, Yibing Shan, David E. Shaw, Daniel J. Rolfe, Peter J. Parker, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
To prevent ligand-independent dimerisation the epidermal growth factor receptor (EGFR) is autoinhibited by an extracellular dimer interaction. Here, the authors use several imaging technologies and simulations to provide structural insights on the in
Externí odkaz:
https://doaj.org/article/d8f1227aa2394ee08a80e9812006d6b2
Autor:
Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these form
Externí odkaz:
https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
Publikováno v:
AIMS Biophysics, Vol 2, Iss 1, Pp 1-7 (2015)
Aggregation of cell surface receptors is believed to be linked to their biological function. In this paper, we disclose the explicit formulation for macromolecular aggregation distribution by means of photobleaching Image Correlation Spectroscopy (pb
Externí odkaz:
https://doaj.org/article/bfe9ad5552e047b090ea9d2efaacf551
Publikováno v:
New Journal of Chemistry. 46:3168-3177
The most potent drug configuration is not necessarily the lowest energy conformer. The optical spectral profile of a flexible TKI depends on the distribution of the conformers and therefore the conditions such as environment (solvent).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a55802794982ff7868d0a63ec2557a8
https://doi.org/10.1039/d1nj04348j
https://doi.org/10.1039/d1nj04348j
Autor:
Rudolf Rigler, Igor F. Tsigelny, Vladana Vukojević, Sho Oasa, Stanko N. Nikolić, Aleksandar J. Krmpot, Jean-Pierre Changeux, Lars Terenius, Andrew H. A. Clayton
Publikováno v:
Analytical Chemistry
Compartmentalization and integration of molecular processes through diffusion are basic mechanisms through which cells perform biological functions. To characterize these mechanisms in live cells, quantitative and ultrasensitive analytical methods wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49188e296691c1133fbc95ca3a32c6f0
http://europepmc.org/articles/PMC8427561
http://europepmc.org/articles/PMC8427561
Autor:
Nguyen H N Tran, Andrew H A Clayton
Publikováno v:
Physical Biology. 20:035001
Signal transduction networks are responsible for transferring biochemical signals from the extracellular to the intracellular environment. Understanding the dynamics of these networks helps understand their biological processes. Signals are often del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5be879a4f0e6c77fa2d7996c875c765
https://doi.org/10.1088/1478-3975/acc300
https://doi.org/10.1088/1478-3975/acc300