Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Andrew H Sims"'
Publikováno v:
Breast Cancer: Basic and Clinical Research, Vol 14 (2020)
Background: Triple-negative breast cancer is an aggressive type of breast cancer with high risk of recurrence. It is still poorly understood and lacks any targeted therapy, which makes it difficult to treat. Thus, it is important to understand the un
Externí odkaz:
https://doaj.org/article/c841407e1b0c4380957860ec53d91da8
Autor:
Marta Canel, David Taggart, Andrew H Sims, David W Lonergan, Irene C Waizenegger, Alan Serrels
Publikováno v:
eLife, Vol 9 (2020)
Focal Adhesion Kinase (FAK) inhibitors are currently undergoing clinical testing in combination with anti-PD-1 immune checkpoint inhibitors. However, which patients are most likely to benefit from FAK inhibitors, and what the optimal FAK/immunotherap
Externí odkaz:
https://doaj.org/article/acfbe23a60634a70bb78633cc9dd44eb
Autor:
Cigdem Selli, Andrew H Sims
Publikováno v:
Breast Cancer: Basic and Clinical Research, Vol 13 (2019)
Neoadjuvant therapy, where patients receive systemic therapy before surgical removal of the tumour, can downstage tumours allowing breast-conserving surgery, rather than mastectomy. In addition to its impact on surgery, the neoadjuvant setting offers
Externí odkaz:
https://doaj.org/article/2e8d62cb25de4cff844aa74a9997a6a9
Autor:
Sherene Loi, Stefan Michiels, Jose Baselga, John M S Bartlett, Sandeep K Singhal, Vicky S Sabine, Andrew H Sims, Tarek Sahmoud, J Michael Dixon, Martine J Piccart, Christos Sotiriou
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0216175 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0053292.].
Externí odkaz:
https://doaj.org/article/d71c1eb6584e47cfbf6051eab8cecf7c
Autor:
Rui Huang, Dana Faratian, Andrew H Sims, Danielle Wilson, Jeremy S Thomas, David J Harrison, Simon P Langdon
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94226 (2014)
Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-7/LCC9) variants was performed to identify modifiers of endocrine sensitivity in breast cancer. Analysis of the
Externí odkaz:
https://doaj.org/article/077d26d1c05848e5befd2f3211436922
Autor:
Rebecca Lamb, Matthew P Ablett, Katherine Spence, Göran Landberg, Andrew H Sims, Robert B Clarke
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67811 (2013)
IntroductionWnt signalling has been implicated in stem cell regulation however its role in breast cancer stem cell regulation remains unclear.MethodsWe used a panel of normal and breast cancer cell lines to assess Wnt pathway gene and protein express
Externí odkaz:
https://doaj.org/article/85060c6ac6284811b7f24663a6a93a54
Autor:
Sherene Loi, Stefan Michiels, Jose Baselga, John M S Bartlett, Sandeep K Singhal, Vicky S Sabine, Andrew H Sims, Tarek Sahmoud, J Michael Dixon, Martine J Piccart, Christos Sotiriou
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53292 (2013)
The phosphatidylinositol 3' kinase (PI3K) pathway is commonly activated in breast cancer and aberrations such as PI3K mutations are common. Recent exciting clinical trial results in advanced estrogen receptor-positive (ER) breast cancer support mTOR
Externí odkaz:
https://doaj.org/article/6b52976f3af14e91b6fddd339081c482
Autor:
Bin Wang, Linsey E Lindley, Virneliz Fernandez-Vega, Megan E Rieger, Andrew H Sims, Karoline J Briegel
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41355 (2012)
The T box transcription factor TBX2, a master regulator of organogenesis, is aberrantly amplified in aggressive human epithelial cancers. While it has been shown that overexpression of TBX2 can bypass senescence, a failsafe mechanism against cancer,
Externí odkaz:
https://doaj.org/article/8462e757685242919a79b196c4911c99
Autor:
Elad Katz, Sylvie Dubois-Marshall, Andrew H Sims, Philippe Gautier, Helen Caldwell, Richard R Meehan, David J Harrison
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17083 (2011)
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility. In human breast cancer, invasion into surround
Externí odkaz:
https://doaj.org/article/1e79f3962f524db5a54b0e90f518ccab
Autor:
Dana Faratian, Andrew H Sims, Peter Mullen, Charlene Kay, Inhwa Um, Simon P Langdon, David J Harrison
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23772 (2011)
Resistance to trastuzumab is a clinical problem, partly due to overriding activation of MAPK/PI3K signalling. Sprouty-family proteins are negative regulators of MAPK/PI3K signalling, but their role in HER2-therapy resistance is unknown.Associations b
Externí odkaz:
https://doaj.org/article/64bdbf45d000409b9204668aede19b7b