Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

Autor: Yan Qiu, Stanley Buffonge, Raina Ramnath, Sophie Jenner, Sarah Fawaz, Kenton P. Arkill, Chris Neal, Paul Verkade, Stephen J. White, Melanie Hezzell, Andrew H. J. Salmon, M.-Saadeh Suleiman, Gavin I. Welsh, Rebecca R. Foster, Paolo Madeddu, Simon C. Satchell

Publikováno v: Qiu, Y, Buffonge, S, Ramnath, R, Jenner, S, Fawaz, S, Arkill, K P, Neal, C, Verkade, P, White, S J, Hezzell, M, Salmon, A H J, Suleiman, M-S, Welsh, G I, Foster, R R, Madeddu, P & Satchell, S C 2022, ' Endothelial glycocalyx is damaged in diabetic cardiomyopathy : angiopoietin 1 restores glycocalyx and improves diastolic function in mice ', Diabetologia, vol. 65, no. 5, pp. 879–894 . https://doi.org/10.1007/s00125-022-05650-4

Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcircu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e35df3bb571173658e77d9051b01825
https://doi.org/10.1007/s00125-022-05650-4

Detection of VEGF-A(xxx)b isoforms in human tissues.

Autor: David O Bates, Athina Mavrou, Yan Qiu, James G Carter, Maryam Hamdollah-Zadeh, Shaney Barratt, Melissa V Gammons, Ann B Millar, Andrew H J Salmon, Sebastian Oltean, Steven J Harper

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68399 (2013)

Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by alternative splicing. Two families of isoforms have been described in humans, pro-angiogenic isoforms typified by VEGF-A165a, and anti-angiogenic isoforms typified

Externí odkaz: https://doaj.org/article/c5e11b23554f49f3992873cd602d0d0f

Acute tubulointerstitial nephritis, treatment with steroid and impact on renal outcomes

Autor: Coralie Bingham, Muhammad N Raza, Muhammad Hadid, Charles E Keen, Andrew H J Salmon

Publikováno v: Nephrology. 17:748-753

Background: The use and timing of steroids in the management of acute tubulointerstitial nephritis (ATIN) remains debatable. Aims: To determine the incidence and aetiology of ATIN in our unit, and to examine trends in the use of steroids and their im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d12e734043decf67ec50fb7238ae2725
https://doi.org/10.1111/j.1440-1797.2012.01648.x

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases

Autor: Bernhard F, Becker, Matthias, Jacob, Stephanie, Leipert, Andrew H J, Salmon, Daniel, Chappell

Publikováno v: British journal of clinical pharmacology. 80(3)

The endothelial glycocalyx has a profound influence at the vascular wall on the transmission of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic conductivity, and on attenuating firm adhesion of blood leukocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eee9dad4e4e84eef3953f0d192ee4e6c
https://pubmed.ncbi.nlm.nih.gov/25778676

Isolated sphenoid sinusitis complicated by meningitis and multiple cerebral infarctions in a renal transplant recipient

Autor: Andrew H. J. Salmon, Christopher D. Steadman, Charles R.V. Tomson

Publikováno v: Nephrology Dialysis Transplantation. 19:242-244

Infection was amongst the most feared complications of renal transplantation in the early era of this technique. Serious infection developed in up to 70% of renal transplant recipients, and a subsequent fatal outcome occurred in as many as between 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269fce5fb4bc4da7748c56dc04917749
https://doi.org/10.1093/ndt/gfg490