Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Andrew H Baker"'
Autor:
William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murphy
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195116 (2018)
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting. In studies to a
Externí odkaz:
https://doaj.org/article/b9a6a700721b4c0887a29d0b18bb7cb1
Autor:
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expre
Externí odkaz:
https://doaj.org/article/3754b0ae722445b28dc0fc7b7de55dfa
Autor:
Jiangtao Ma, Margaret R Duffy, Lin Deng, Rachel S Dakin, Taco Uil, Jerome Custers, Sharon M Kelly, John H McVey, Stuart A Nicklin, Andrew H Baker
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004673 (2015)
Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX)
Externí odkaz:
https://doaj.org/article/6ac6df5e8e0a463095cf3f42d8085f51
Autor:
Victoria J. M. Reid, Wesley K. X. McLoughlin, Kalyani Pandya, Holly Stott, Monika Iškauskienė, Algirdas Šačkus, Judit A. Marti, Dominic Kurian, Thomas M. Wishart, Christophe Lucatelli, Dan Peters, Gillian A. Gray, Andrew H. Baker, David E. Newby, Patrick W. F. Hadoke, Adriana A. S. Tavares, Mark G. MacAskill
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Background Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targeting these processes cou
Externí odkaz:
https://doaj.org/article/b3fa38c72c4943ada2374cbe0f7b0709
Autor:
Angela C Bradshaw, Alan L Parker, Margaret R Duffy, Lynda Coughlan, Nico van Rooijen, Veli-Matti Kähäri, Stuart A Nicklin, Andrew H Baker
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001142 (2010)
Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown. Upon contact with blood, vectors based on adenovirus serotype 5 (Ad5) binds to FX via the hexon
Externí odkaz:
https://doaj.org/article/d0627ccd171b4c2f9e6d275e4aeddb5b
Autor:
Sandosh Padmanabhan, Olle Melander, Toby Johnson, Anna Maria Di Blasio, Wai K Lee, Davide Gentilini, Claire E Hastie, Cristina Menni, Maria Cristina Monti, Christian Delles, Stewart Laing, Barbara Corso, Gerjan Navis, Arjan J Kwakernaak, Pim van der Harst, Murielle Bochud, Marc Maillard, Michel Burnier, Thomas Hedner, Sverre Kjeldsen, Björn Wahlstrand, Marketa Sjögren, Cristiano Fava, Martina Montagnana, Elisa Danese, Ole Torffvit, Bo Hedblad, Harold Snieder, John M C Connell, Morris Brown, Nilesh J Samani, Martin Farrall, Giancarlo Cesana, Giuseppe Mancia, Stefano Signorini, Guido Grassi, Susana Eyheramendy, H Erich Wichmann, Maris Laan, David P Strachan, Peter Sever, Denis Colm Shields, Alice Stanton, Peter Vollenweider, Alexander Teumer, Henry Völzke, Rainer Rettig, Christopher Newton-Cheh, Pankaj Arora, Feng Zhang, Nicole Soranzo, Timothy D Spector, Gavin Lucas, Sekar Kathiresan, David S Siscovick, Jian'an Luan, Ruth J F Loos, Nicholas J Wareham, Brenda W Penninx, Ilja M Nolte, Martin McBride, William H Miller, Stuart A Nicklin, Andrew H Baker, Delyth Graham, Robert A McDonald, Jill P Pell, Naveed Sattar, Paul Welsh, Global BPgen Consortium, Patricia Munroe, Mark J Caulfield, Alberto Zanchetti, Anna F Dominiczak
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001177 (2010)
Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existen
Externí odkaz:
https://doaj.org/article/57807fab5b1d4659bc82c7a7a71fbacc
Autor:
Gianfranco Matrone, Sung Yun Jung, Jong Min Choi, Antrix Jain, Hon-Chiu Eastwood Leung, Kimal Rajapakshe, Cristian Coarfa, Julie Rodor, Martin A. Denvir, Andrew H. Baker, John P. Cooke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The role of the post-translational modifications in tissue regeneration is still not clearly understood. Here, the authors show that many nuclear proteins change S-nitrosylation state in the regenerating zebrafish tailfin, highlighting the importance
Externí odkaz:
https://doaj.org/article/adfe028e44264c2b8db2eceb6959bc23
Autor:
Ana-Mishel Spiroski, Ian R. McCracken, Adrian Thomson, Marlene Magalhaes-Pinto, Mukesh K. Lalwani, Kathryn J. Newton, Eileen Miller, Cecile Bénézech, Patrick Hadoke, Mairi Brittan, Joanne C. Mountford, Abdelaziz Beqqali, Gillian A. Gray, Andrew H. Baker
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundMechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little direct evidence of
Externí odkaz:
https://doaj.org/article/7124b2c9b1f04665b50be22f557a3574
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 1, Iss , Pp 100013- (2022)
Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality.The molecular mechanisms
Externí odkaz:
https://doaj.org/article/a6423ef9dde948cc8c7a5fc77604305c
Autor:
Frederike Boos, James A. Oo, Timothy Warwick, Stefan Günther, Judit Izquierdo Ponce, Melina Lopez, Diba Rafii, Giulia Buchmann, Minh Duc Pham, Zahraa S. Msheik, Tianfu Li, Sandra Seredinski, Shaza Haydar, Sepide Kashefiolasl, Karl H. Plate, Rüdiger Behr, Matthias Mietsch, Jaya Krishnan, Soni S. Pullamsetti, Sofia-Iris Bibli, Rabea Hinkel, Andrew H. Baker, Reinier A. Boon, Marcel H. Schulz, Ilka Wittig, Francis J. Miller, Ralf P. Brandes, Matthias S. Leisegang
Publikováno v:
Basic Research in Cardiology, 118(1):5. Springer
Boos, F, Oo, J A, Warwick, T, Günther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic research in cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Boos, F, Oo, J A, Warwick, T, G?nther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R D, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S-I, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic Research in Cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Basic Research in Cardiology, 118(1):5. D. Steinkopff-Verlag
Boos, F, Oo, J A, Warwick, T, Günther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic research in cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Boos, F, Oo, J A, Warwick, T, G?nther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R D, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S-I, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic Research in Cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Basic Research in Cardiology, 118(1):5. D. Steinkopff-Verlag
Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their vascular functions are largely undefin