Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Andrew Godkin"'
Autor:
Martin J. Scurr, George Lippiatt, Lorenzo Capitani, Kirsten Bentley, Sarah N. Lauder, Kathryn Smart, Michelle S. Somerville, Tara Rees, Richard J. Stanton, Awen Gallimore, James P. Hindley, Andrew Godkin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The presence of SARS-CoV-2-specific antibodies alone is not an accurate determinant of immunity. In this work, the authors investigate if whole-blood based measurement of SARS-CoV-2 specific T cell responses could prognosticate the risk of possible S
Externí odkaz:
https://doaj.org/article/d478f34a0e4948beb39a42e0ae302a63
Autor:
Yuan Chen, Georgina H. Mason, D. Oliver Scourfield, Alexander Greenshields-Watson, Tracey A. Haigh, Andrew K. Sewell, Heather M. Long, Awen M. Gallimore, Pierre Rizkallah, Bruce J. MacLachlan, Andrew Godkin
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112827- (2023)
Summary: CD4+ T cells recognize a broad range of peptide epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit COVID-19 disease. We demonstrate that the immunogenicity of SARS-CoV-2 pept
Externí odkaz:
https://doaj.org/article/89d593fdc3ac46c694db2226da7cae58
Autor:
Rory M. Crean, Bruce J. MacLachlan, Florian Madura, Thomas Whalley, Pierre J. Rizkallah, Christopher J. Holland, Catriona McMurran, Stephen Harper, Andrew Godkin, Andrew K. Sewell, Christopher R. Pudney, Marc W. van der Kamp, David K. Cole
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 443-456 (2020)
Immuno-oncology approaches that utilize T cell receptors (TCRs) are becoming highly attractive because of their potential to target virtually all cellular proteins, including cancer-specific epitopes, via the recognition of peptide-human leukocyte an
Externí odkaz:
https://doaj.org/article/468343d29a914222a4306cde545a8b9d
Autor:
Nwe Ni Than, James Hodson, Daniel Schmidt-Martin, Richard Taubert, Rebecca E. Wawman, Meemee Botter, Nishant Gautam, Kilian Bock, Rebecca Jones, Gautham D Appanna, Andrew Godkin, Aldo J. Montano-Loza, Frank Lammert, Christoph Schramm, Michael P. Manns, Mark Swain, Kelly W. Burak, David H. Adams, Gideon M Hirschfield, Ye Htun Oo
Publikováno v:
JHEP Reports, Vol 1, Iss 6, Pp 437-445 (2019)
Background & Aims: Treatment options remain limited for patients with autoimmune hepatitis (AIH), while there are still concerns over the consequences of long-term corticosteroid use. A few studies have suggested a role for B cell-driven autoimmune l
Externí odkaz:
https://doaj.org/article/bcb9f7c48c3a4df4a706283363e04ef1
Autor:
Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Åsa V. Keita, Awen M. Gallimore, Andrew Godkin
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohn’s disease and pote
Externí odkaz:
https://doaj.org/article/865832664a054e5190d402ae3a6a6bd7
Autor:
Emma Jones, Andrew Godkin, Sarah Nicol Lauder, Kathryn Smart, Veerle Kersemans, Danny Allen, Jake Scott, Ana Pires, Stefan Milutinovic, Michelle Somerville, Sean Smart, Paul Kinchesh, Elena Lopez-Guadamillas, Ellyn Hughes, Martin Scurr, Lori S Friedman, Bart Vanhaesebroeck, Awen Gallimore
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Despite striking successes, immunotherapies aimed at increasing cancer-specific T cell responses are unsuccessful in most patients with cancer. Inactivating regulatory T cells (Treg) by inhibiting the PI3Kδ signaling enzyme has shown prom
Externí odkaz:
https://doaj.org/article/03253b8693d64d3c84a6f9eeb342088e
Autor:
Christopher J. Holland, Bruce J. MacLachlan, Valentina Bianchi, Sophie J. Hesketh, Richard Morgan, Owen Vickery, Anna M. Bulek, Anna Fuller, Andrew Godkin, Andrew K. Sewell, Pierre J. Rizkallah, Stephen Wells, David K. Cole
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
T-cell immunity is controlled by T cell receptor (TCR) binding to peptide major histocompatibility complexes (pMHCs). The nature of the interaction between these two proteins has been the subject of many investigations because of its central role in
Externí odkaz:
https://doaj.org/article/e3ef9d8a5f414323a84758bdf8c25ac1
Autor:
Mathew Clement, Morgan Marsden, Maria A Stacey, Juneid Abdul-Karim, Silvia Gimeno Brias, Diana Costa Bento, Martin J Scurr, Peter Ghazal, Casey T Weaver, Gianluca Carlesso, Simon Clare, Simon A Jones, Andrew Godkin, Gareth W Jones, Ian R Humphreys
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006050 (2016)
CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (M
Externí odkaz:
https://doaj.org/article/7fe395ac2dd442b6bb7558097586ab3e
Autor:
Sai Ambati, Bazga Ali, Owen Seddon, Andrew Godkin, Martin Scurr, Catherine Moore, Clare Rowntree, Jonathan Underwood
Publikováno v:
International Journal of Hematology. 117:765-768
SARS-CoV-2 virus is a single-stranded enveloped RNA virus, which causes coronavirus disease. Most of the immunocompetent patients with SARS-CoV-2 infection do have mild to moderate respiratory illness; however, in immunocompromised patients, the cour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c9a21227470a9cd0d71295c495f1801
https://doi.org/10.1007/s12185-022-03518-2
https://doi.org/10.1007/s12185-022-03518-2
Autor:
Thomas Peter Ignatius Pembroke, Gareth John, Berry Puyk, Keith Howkins, Ruth Clarke, Fidan Yousuf, Marek Czajkowski, Andrew Godkin, Jane Salmon, Andrew Yeoman
Publikováno v:
World Journal of Hepatology. 15:89-106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eafec8d1bd880cc8715dcf0b37267d1
https://doi.org/10.4254/wjh.v15.i1.89
https://doi.org/10.4254/wjh.v15.i1.89