Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andrew G. Reaume"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A target-based drug discovery strategy has led to a bias away from low molecular weight (MWT) drug discovery. Analysis of the ACS chemistry registration system shows that most low MWT drugs were first made in the time era before target-based drug dis
Externí odkaz:
https://doaj.org/article/91a24f8dc14a4e93a478d55434a63958
Autor:
Candida J. Rebello, Ann A. Coulter, Andrew G. Reaume, Weina Cong, Luke A. Cusimano, Frank L. Greenway
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1196 (2021)
A glucose-lowering medication that acts by a different mechanism than metformin, or other approved diabetes medications, can supplement monotherapies when patients fail to meet blood glucose goals. We examined the actions underlying the effects of an
Externí odkaz:
https://doaj.org/article/4516d1342a1f4ef69cc538ba787de368
Publikováno v:
Drug Repurposing ISBN: 9781788019033
The drug discovery and development process is notoriously wrought with a high failure rate. A key contributor to this phenomenon is our significantly incomplete understanding of the biological systems that we are manipulating. We propose that an elem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c1fc45b2d4aa7ce301b287f70538a9a
https://doi.org/10.1039/9781839163401-00196
https://doi.org/10.1039/9781839163401-00196
Autor:
Andrew G. Reaume
Publikováno v:
Journal of Commercial Biotechnology. 26
For the last 15 years the drug discovery strategy referred to as “drug-repositioning” has been a recognized approach towards bringing new therapeutics to market and has continued to grow in popularity over this time frame. Melior Discovery is a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8aacd2359616fc285622c8c0ffcb0d7
https://doi.org/10.5912/jcb1011
https://doi.org/10.5912/jcb1011
Autor:
Andrew G Reaume, Candida J. Rebello, Weina Cong, Ann A. Coulter, Luke A Cusimano, Frank L. Greenway
Publikováno v:
Pharmaceuticals; Volume 14; Issue 11; Pages: 1196
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 1196, p 1196 (2021)
Pharmaceuticals
Pharmaceuticals, Vol 14, Iss 1196, p 1196 (2021)
A glucose-lowering medication that acts by a different mechanism than metformin, or other approved diabetes medications, can supplement monotherapies when patients fail to meet blood glucose goals. We examined the actions underlying the effects of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae7c7ff0062874a1b7f2040308a3d59
Autor:
Andrew G. Reaume, John R. Ciallella
Publikováno v:
Drug Discovery Today: Technologies. 23:45-52
In vivo phenotypic screening and drug repositioning are strategies developed as alternatives to underperforming hypothesis-driven molecular target based drug discovery efforts. This article reviews examples of drugs identified by phenotypic observati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b547ce7aaef4beb60cf76d16c28e4792
https://doi.org/10.1016/j.ddtec.2017.04.001
https://doi.org/10.1016/j.ddtec.2017.04.001
Publikováno v:
Drug Repositioning ISBN: 9781315373669
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea902f15c17bbded3039015c919676d7
https://doi.org/10.4324/9781315373669-7
https://doi.org/10.4324/9781315373669-7
Autor:
Andrew G. Reaume
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 8:85-88
The tremendous biological complexity associated with living systems results in significant limitations on the reductionist or target-based drug discovery approach. Increasingly it is being recognized that allowing for more serendipity to enter drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3d088bd8824ca72ab9ecd3acba4d946
https://doi.org/10.1016/j.ddstr.2011.09.007
https://doi.org/10.1016/j.ddstr.2011.09.007
Autor:
Håkan Jakobson, Stefan L. Marklund, Samar Basu, Andrew G. Reaume, Marie-Louise Sentman, Micael Granström
Publikováno v:
Journal of Biological Chemistry. 281:6904-6909
Mice lacking the secreted extracellular superoxide dismutase (EC-SOD) or the cytosolic copper- and zinc-containing SOD (CuZn-SOD) show relatively mild phenotypes. To explore the possibility that the isoenzymes have partly overlapping functions, singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91a37065c1a6920f83e726b02e58841
https://doi.org/10.1074/jbc.m510764200
https://doi.org/10.1074/jbc.m510764200
Autor:
Stephen P. Trusko, Andrew G. Reaume, Mary J. Savage, Yin-Guo Lin, Richard W. Scott, Dorothy G. Flood, Robert Siman
Publikováno v:
The Journal of Neuroscience. 20:8717-8726
The pathogenic mechanism linking presenilin-1 (PS-1) gene mutations to familial Alzheimer's disease (FAD) is uncertain, but has been proposed to include increased neuronal sensitivity to degeneration and enhanced amyloidogenic processing of the β-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3340e52f6a6344c42eb46e5fcfe102e
https://doi.org/10.1523/jneurosci.20-23-08717.2000
https://doi.org/10.1523/jneurosci.20-23-08717.2000