Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andrew G. Raub"'
Autor:
Sunhee Hwang, Karen Mruk, Simin Rahighi, Andrew G. Raub, Che-Hong Chen, Lisa E. Dorn, Naoki Horikoshi, Soichi Wakatsuki, James K. Chen, Daria Mochly-Rosen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency provides insufficient protection from oxidative stress, contributing to diverse human pathologies. Here, the authors identify a small molecule that increases the activity and/or stability of mutant
Externí odkaz:
https://doaj.org/article/1d179241d985451cb9ca3ac72357b58a
Autor:
Adriana A. Garcia, Daria Mochly-Rosen, Naoki Horikoshi, Rachel Broweleit, Joshua Broweleit, Cornelius Gati, Andrew G. Raub, Esteban Vöhringer-Martinez, Andrew Chiang, Alexander Batyuk, Carlos Castillo-Orellana, Fatemeh Jabbarpour, Xinyu Xiang, Soichi Wakatsuki, Sunhee Hwang, Tsutomu Matsui
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Mechanism of the loss of activity of the most severe patient-derived mutants of glucose-6-phosphate dehydrogenase (G6PD) deficiency has remained elusive despite the availability of the G6PD structures for decades. Structural and biophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e84d3ef4fc83176d45ea3213276698
https://pubmed.ncbi.nlm.nih.gov/33468660
https://pubmed.ncbi.nlm.nih.gov/33468660
Autor:
Che-Hong Chen, Daria Mochly-Rosen, Soichi Wakatsuki, Lisa E. Dorn, James K. Chen, Andrew G. Raub, Simin Rahighi, Karen Mruk, Naoki Horikoshi, Sunhee Hwang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, one of the most common human genetic enzymopathies, is caused by over 160 different point mutations and contributes to the severity of many acute and chronic diseases associated with oxidative stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fd309c58df8e619586dc5dd2a6bd7f
https://doaj.org/article/1d179241d985451cb9ca3ac72357b58a
https://doaj.org/article/1d179241d985451cb9ca3ac72357b58a
Autor:
Naoki Horikoshi, Anna D Cunningham, Simin Rahighi, Daria Mochly-Rosen, Sunhee Hwang, Andrew G. Raub, Soichi Wakatsuki
Publikováno v:
ChemMedChem
We recently identified AG1, a small-molecule activator that functions by promoting oligomerization of glucose-6-phosphate dehydrogenase (G6PD) to the catalytically competent forms. Biochemical experiments indicate that the activation of G6PD by the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732c653d1821c153ddbf07ae11c58eeb
https://europepmc.org/articles/PMC6701841/
https://europepmc.org/articles/PMC6701841/
Autor:
Soichi Wakatsuki, Sunhee Hwang, Estevan Vöhringer-Martinez, Cornelius Gati, Carlos Castillo-Orellana, Adriana A. Garcia, Naoki Horikoshi, Daria Mochly-Rosen, Andrew G. Raub, Fatemeh Jabbarpour, Tsutomu Matsui
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc85e1c43631e224697b3546bd9ee782
https://doi.org/10.1096/fasebj.2020.34.s1.08997
https://doi.org/10.1096/fasebj.2020.34.s1.08997
Publikováno v:
Journal of the American Chemical Society
New reactions and reagents that allow for multiple bond-forming events per synthetic operation are required to achieve structural complexity and thus value with step-, time-, cost-, and waste-economy. Here we report a new class of reagents that funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552f3c9315cc437f4f8adc9769d37255
https://doi.org/10.1021/jacs.5b04091
https://doi.org/10.1021/jacs.5b04091
Publikováno v:
ChemInform. 47
A one-pot procedure is developed consisting of a Diels—Alder reaction of the tetramethyleneethane equivalent (II) and dienophiles, subsequent elimination to give a second diene, captured in a subsequent [4 + 2] cycloaddition to afford compounds lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409af68441b6df0f490fa3fab8a1e575
https://doi.org/10.1002/chin.201602031
https://doi.org/10.1002/chin.201602031
Autor:
Peter Hastings, Madalyn M. Metz, Allegra C. Mount, Nicole M. Thomas, Kyle L. Naughton, Steven G. Sogo, Sean Jackson, Bruce Blumberg, Andrew G. Raub, John Greaves, Ashley L. Eaton, Terrence J. Collins, Natalie C. Pueyo
Publikováno v:
Journal of chemical education. 90(3)
A chemical research program at a public high school has been developed. The full-year Advanced Chemical Research class (ACR) in the high school enrolls 20 to 30 seniors each year, engaging them in long-term experimental projects. Through partnerships
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ceda9b73778f15a8b25e53f310f1046
https://pubmed.ncbi.nlm.nih.gov/23585695
https://pubmed.ncbi.nlm.nih.gov/23585695