Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrew G. Pinder"'
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57162 (2013)
The activation of soluble guanylate cyclase (sGC) by nitric oxide (NO) and other ligands has been extensively investigated for many years. In the present study we considered the effect of molecular oxygen (O2) on sGC both as a direct ligand and its a
Externí odkaz:
https://doaj.org/article/04c36299ca6d470abcb2134b860e6455
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e57162 (2013)
PLoS ONE, Vol 8, Iss 2, p e57162 (2013)
The activation of soluble guanylate cyclase (sGC) by nitric oxide (NO) and other ligands has been extensively investigated for many years. In the present study we considered the effect of molecular oxygen (O2) on sGC both as a direct ligand and its a
Autor:
Richard Anderson, Stephen C. Rogers, Ewelina Sagan, Philip E. James, Andrew G. Pinder, Nurudeen Hassan, Keith Morris, Shantu Bundhoo
Publikováno v:
European journal of pharmacology. 670(2-3)
Thienopyridines (ticlopidine, clopidogrel and prasugrel) are pro-drugs that require metabolism to exhibit a critical thiol group in the active form that binds to the P2Y₁₂ receptor to inhibit platelet activation and prevent thrombus formation in
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 298(2)
Inorganic nitrite has recently been recognized to possess vascular activity that is enhanced in hypoxia. This has been demonstrated in humans in the forearm vascular bed. In animal models nitrite reduces pulmonary vascular resistance, but its effects
Background and purpose: It is postulated that nitrite requires reduction to nitric oxide in order to exert its relaxant effect upon isolated hypoxic vessels. Herein, we evaluate the relative contribution of nitric oxide and characterize the downstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80970036d205a2c25cc28102ef776728
https://europepmc.org/articles/PMC2765305/
https://europepmc.org/articles/PMC2765305/
Autor:
Thomas E, Ingram, Andrew G, Pinder, Alexandra B, Milsom, Stephen C, Rogers, Dewi E, Thomas, Philip E, James
Publikováno v:
Advances in experimental medicine and biology. 645
This study uses an organ chamber bioactivity assay to characterise the direct effect of sodium nitrite upon rabbit blood vessels (aorta (Ao), inferior vena cava (IVC) and pulmonary artery (PA)) in a haemoglobin independent/variable oxygen environment
Publikováno v:
Advances in experimental medicine and biology. 645
The vasorelaxant properties of red blood cells (RBCs) have been implicated in both the control of normal vascular tone and the protection of tissues from ischemic events. The identity of the vasorelaxant released from RBCs has yet to be elucidated, h
Autor:
Philip E. James, Andrew G. Pinder
Publikováno v:
Circulation Research. 104
To the Editor: Webb and Milsom et al1 present the intriguing finding that endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) and potentially RBCs is responsible under hypoxic conditions for nitrite (NO2•) re
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 476
A plethora of publications on techniques and methodologies for measuring nitric oxide (NO) or reaction products of NO (NO metabolites) has served in recent years to complicate and confuse the majority of researchers interested in this field. Here, we
Autor:
Alexandra B. Milsom, Dewi E. Thomas, Thomas E. Ingram, Stephen C. Rogers, Andrew G. Pinder, Philip E. James
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387859972
This study uses an organ chamber bioactivity assay to characterise the direct effect of sodium nitrite upon rabbit blood vessels (aorta (Ao), inferior vena cava (IVC) and pulmonary artery (PA)) in a haemoglobin independent/variable oxygen environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ec4d4428100a6045f4100cb623eec69
https://doi.org/10.1007/978-0-387-85998-9_4
https://doi.org/10.1007/978-0-387-85998-9_4