Výsledky vyhledávání - "Andrew G. Cox"

Akademický článek

Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity

Autor: Yang Zhang, Christelle Guillermier, Thomas De Raedt, Andrew G. Cox, Ophelia Maertens, Dean Yimlamai, Mingyue Lun, Adam Whitney, Richard L. Maas, Wolfram Goessling, Karen Cichowski, Matthew L. Steinhauser

Publikováno v: iScience, Vol 23, Iss 8, Pp 101355- (2020)

Summary: Malignant tumors exhibit high degrees of genomic heterogeneity at the cellular level, leading to the view that subpopulations of tumor cells drive growth and treatment resistance. To examine the degree to which tumors also exhibit metabolic

Externí odkaz: https://doaj.org/article/65c606e11867455bb254d8409165dc47

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Akademický článek

S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury

Autor: Andrew G. Cox, Diane C. Saunders, Peter B. Kelsey Jr., Allie A. Conway, Yevgenia Tesmenitsky, Julio F. Marchini, Kristin K. Brown, Jonathan S. Stamler, Dorothy B. Colagiovanni, Gary J. Rosenthal, Kevin J. Croce, Trista E. North, Wolfram Goessling

Publikováno v: Cell Reports, Vol 6, Iss 1, Pp 56-69 (2014)

Toxic liver injury is a leading cause of liver failure and death because of the organ’s inability to regenerate amidst massive cell death, and few therapeutic options exist. The mechanisms coordinating damage protection and repair are poorly unders

Externí odkaz: https://doaj.org/article/b0dbc49cf4944575a2e417e636885493

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Akademický článek

Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk

Autor: Lin Grimm, Hiroyuki Nakajima, Smrita Chaudhury, Neil I Bower, Kazuhide S Okuda, Andrew G Cox, Natasha L Harvey, Katarzyna Koltowska, Naoki Mochizuki, Benjamin M Hogan

Publikováno v: eLife, Vol 8 (2019)

Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway and effectors Yap and Taz control

Externí odkaz: https://doaj.org/article/939477b57dd243f285d6fad89559ef17

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The KEAP1–NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis

Autor: Athena Jessica S. Ong, Cerys E. Bladen, Tara A. Tigani, Anthony P. Karamalakis, Kimberley J. Evason, Kristin K. Brown, Andrew G. Cox

Publikováno v: Proceedings of the National Academy of Sciences. 120

The maintenance of redox and metabolic homeostasis is integral to embryonic development. Nuclear factor erythroid 2-related factor 2 (NRF2) is a stress-induced transcription factor that plays a central role in the regulation of redox balance and cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c130ebcc53b94ecc360d6c8b4a5e8dc
https://doi.org/10.1073/pnas.2217425120

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