Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Andrew G Myers"'
Autor:
Nozomu Obana, Hiraku Takada, Caillan Crowe-McAuliffe, Mizuki Iwamoto, Artyom A Egorov, Kelvin J Y Wu, Shinobu Chiba, Victoriia Murina, Helge Paternoga, Ben I C Tresco, Nobuhiko Nomura, Andrew G Myers, Gemma C Atkinson, Daniel N Wilson, Vasili Hauryliuk
Publikováno v:
Nucleic Acids Research. 51:4536-4554
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The diversity of chromosomally-encoded ARE-ABCFs is far from being fully exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d26f7fbc7cdcb357bec011d2f729f9
https://doi.org/10.1093/nar/gkad193
https://doi.org/10.1093/nar/gkad193
Publikováno v:
The Journal of Organic Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fff013bbc672fc2347a092c4cc5ed72
https://doi.org/10.1021/acs.joc.3c00492
https://doi.org/10.1021/acs.joc.3c00492
Autor:
Nozomu Obana, Hiraku Takada, Caillan Crowe-McAuliffe, Mizuki Iwamoto, Artyom A. Egorov, Kelvin J.Y. Wu, Victoriia Murina, Helge Paternoga, Ben I.C. Tresco, Nobuhiko Nomura, Andrew G. Myers, Gemma C. Atkinson, Daniel N. Wilson, Vasili Hauryliuk
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The diversity of chromosomally-encoded ARE-ABCFs is far from being fully exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cc36fda8320347a4d762cc19615334
https://doi.org/10.1101/2022.12.05.519065
https://doi.org/10.1101/2022.12.05.519065
Publikováno v:
Journal of the American Chemical Society. 143:11019-11025
A gram-scale synthesis of iboxamycin, an antibiotic candidate bearing a fused bicyclic amino acid residue, is presented. A pivotal transformation in the route involves an intramolecular hydrosilylation-oxidation sequence to set the ring-fusion stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccb13267bbda40290edfddfbbb246b3
https://doi.org/10.1021/jacs.1c03529
https://doi.org/10.1021/jacs.1c03529
Autor:
Andrew G. Myers, Roger B Clark
Publikováno v:
Accounts of Chemical Research. 54:1635-1645
Macrolides are among the most widely prescribed antibiotics, particularly for bacterial lung infections, due to their favorable safety, oral bioavailability, and spectrum of activity against Gram-positive pathogens such as Streptococcus pneumoniae, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc1895e59ba7f9f4c65d500b36f66fb
https://doi.org/10.1021/acs.accounts.1c00020
https://doi.org/10.1021/acs.accounts.1c00020
Autor:
Mark P. Jedrychowski, Pedro Latorre-Muro, Christopher F. Bennett, Kamar Reda, Steven P. Gygi, Elizabeth A. Perry, Richard Porter Ladley, Katherine E. O’Malley, Chi Luo, Eduardo Balsa, Andrew G. Myers, Peter M. Wright, Pere Puigserver
Publikováno v:
Nature metabolism
Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from mutations in nuclear or mitochondrial DNA genes encoding mitochondrial proteins1,2. MDs cause pathologies with severe tissue damage and ultimately death3,4. There are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7c377e52a0e6d3efcec8390760198b
https://doi.org/10.1038/s42255-020-00334-y
https://doi.org/10.1038/s42255-020-00334-y
Autor:
Hiraku, Takada, Zachary F, Mandell, Helen, Yakhnin, Anastasiya, Glazyrina, Shinobu, Chiba, Tatsuaki, Kurata, Kelvin J Y, Wu, Ben I C, Tresco, Andrew G, Myers, Gemma C, Aktinson, Paul, Babitzke, Vasili, Hauryliuk
Publikováno v:
Nucleic acids research. 50(11)
Since antibiotic resistance is often associated with a fitness cost, bacteria employ multi-layered regulatory mechanisms to ensure that expression of resistance factors is restricted to times of antibiotic challenge. In Bacillus subtilis, the chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d02a4d99bc9d83327b448d55cc57303
https://pubmed.ncbi.nlm.nih.gov/35699226
https://pubmed.ncbi.nlm.nih.gov/35699226
Autor:
Tetiana, Brodiazhenko, Kathryn Jane, Turnbull, Kelvin J Y, Wu, Hiraku, Takada, Ben I C, Tresco, Tanel, Tenson, Andrew G, Myers, Vasili, Hauryliuk
Publikováno v:
JAC-antimicrobial resistance. 4(3)
Listeriosis is a food-borne disease caused by the Gram-positive Bacillota (Firmicute) bacteriumWe have established newly developed lincosamide iboxamycin as a potential novel antilisterial agent.We determined MICs of the lincosamides lincomycin, clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::735ba7a1a456f5e7b70528fa601a08b8
https://pubmed.ncbi.nlm.nih.gov/35733912
https://pubmed.ncbi.nlm.nih.gov/35733912
Autor:
Tetiana Brodiazhenko, Kathryn Jane Turnbull, Kelvin J.Y. Wu, Hiraku Takada, Ben I.C. Tresco, Tanel Tenson, Andrew G. Myers, Vasili Hauryliuk
Listeriosis is a dangerous food-borne bacterial disease caused by the Gram-positive Bacillota (Firmicute) bacterium Listeria monocytogenes. In this report, we show that the synthetic lincosamide iboxamycin is highly active against L. monocytogenes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8e024d1ea69c1c277e792ec2e7e9696
https://doi.org/10.1101/2022.02.28.482263
https://doi.org/10.1101/2022.02.28.482263
Publikováno v:
Journal of the American Chemical Society. 143(18)
The development of a flexible, component-based synthetic route to the aminosugar fragment of the lincosamide antibiotics is described. This synthetic route hinges on the application and extension of nitroaldol chemistry to forge strategic bonds withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cdeb629ee4d1c2d021d12bc9579376
https://pubmed.ncbi.nlm.nih.gov/33930268
https://pubmed.ncbi.nlm.nih.gov/33930268