Zobrazeno 1 - 10
of 778
pro vyhledávání: '"Andrew G, Clark"'
Autor:
Yassi Hafezi, Arsen Omurzakov, Jolie A. Carlisle, Ian V. Caldas, Mariana F. Wolfner, Andrew G. Clark
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Unique patterns of inheritance and selection on Y chromosomes have led to the evolution of specialized gene functions. We report CRISPR mutants in Drosophila of the Y-linked gene, WDY, which is required for male fertility. We demonstrate tha
Externí odkaz:
https://doaj.org/article/ff6e0fb66ec043b285dde28fa594f227
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 11 (2024)
Background Mendelian randomization (MR) studies suggest a causal effect of iron status on cardiovascular disease (CVD) risk, but it is unknown if these associations are confounded by pleiotropic effects of the instrumental variables on CVD risk facto
Externí odkaz:
https://doaj.org/article/a4c5c60716064615a41019aff8398149
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background The female reproductive tract is exposed directly to the male’s ejaculate, making it a hotspot for mating-induced responses. In Drosophila melanogaster, changes in the reproductive tract are essential to optimize fertility. Many
Externí odkaz:
https://doaj.org/article/d0d4fe171343466693b8edcd4123128a
Autor:
Nora C Brown, Benjamin Gordon, Caitlin E McDonough-Goldstein, Snigdha Misra, Geoffrey D Findlay, Andrew G Clark, Mariana Federica Wolfner
Publikováno v:
eLife, Vol 12 (2023)
In Drosophila melanogaster and other insects, the seminal fluid proteins (SFPs) and male sex pheromones that enter the female with sperm during mating are essential for fertility and induce profound post-mating effects on female physiology. The SFPs
Externí odkaz:
https://doaj.org/article/eb5c76eefee346ccae349db454c40fcc
Autor:
Amanda J Lea, Andrew G Clark, Andrew W Dahl, Orrin Devinsky, Angela R Garcia, Christopher D Golden, Joseph Kamau, Thomas S Kraft, Yvonne A L Lim, Dino J Martins, Donald Mogoi, Päivi Pajukanta, George H Perry, Herman Pontzer, Benjamin C Trumble, Samuel S Urlacher, Vivek V Venkataraman, Ian J Wallace, Michael Gurven, Daniel E Lieberman, Julien F Ayroles
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002311 (2023)
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes are among a long list of "lifestyle" diseases that were rare throughout human history but are now common. The evolutionary mismatch hypoth
Externí odkaz:
https://doaj.org/article/2745ad47e80c435daa7ab7fa5ed0c557
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102473- (2023)
Summary: Integrin-dependent cell-extracellular matrix adhesion is essential for wound healing, embryonic development, immunity, and tissue organization. Here, we present a protocol for the imaging and quantitative analysis of integrin-dependent cell-
Externí odkaz:
https://doaj.org/article/7b1d709546c84eb8bff5cfd145aa22ff
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Epithelial tissues are crucial to maintaining healthy organization and compartmentalization in various organs and act as a first line of defense against infection in barrier organs such as the skin, lungs and intestine. Disruption or injury to these
Externí odkaz:
https://doaj.org/article/f222e85a03af45658778ae01735c9ed1
Autor:
Yiqin Wang, Xiaoxian Guo, Xiumei Hong, Guoying Wang, Colleen Pearson, Barry Zuckerman, Andrew G. Clark, Kimberly O. O’Brien, Xiaobin Wang, Zhenglong Gu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Most genetic studies of autism spectrum disorder (ASD) have focused on the nuclear genome. Here, the authors show that variations in mitochondrial DNA, detectable at birth, are also associated with risk of ASD.
Externí odkaz:
https://doaj.org/article/942ae5215da2437b81e1761dbba00c9b
Autor:
Tram N. Nguyen, Nancy Chen, Elissa J. Cosgrove, Reed Bowman, John W. Fitzpatrick, Andrew G. Clark
Publikováno v:
Evolutionary Applications, Vol 15, Iss 6, Pp 1018-1027 (2022)
Abstract Understanding the genomic consequences of population decline is important for predicting species' vulnerability to intensifying global change. Empirical information about genomic changes in populations in the early stages of decline, especia
Externí odkaz:
https://doaj.org/article/a4a0d750f20a4efd897fb6a5da877f08
Autor:
Matthew Metzloff, Emily Yang, Sumit Dhole, Andrew G. Clark, Philipp W. Messer, Jackson Champer
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Homing gene drives hold great promise for the genetic control of natural populations. However, current homing systems are capable of spreading uncontrollably between populations connected by even marginal levels of migration. This
Externí odkaz:
https://doaj.org/article/82e027ed2a8643468a7c8a40fd4bfad1