Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andrew G, Cairns"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in clinical trials and molecular glues such as immunomodulatory imide drugs (IMiDs) already well established in the treatment of ce
Externí odkaz:
https://doaj.org/article/e0ff70d75267414ca024682086e6d311
Autor:
Omer Ad, Kyle S. Hoffman, Andrew G. Cairns, Aaron L. Featherston, Scott J. Miller, Dieter Söll, Alanna Schepartz
Publikováno v:
ACS Central Science, Vol 5, Iss 7, Pp 1289-1294 (2019)
Externí odkaz:
https://doaj.org/article/faa14b0313454a72837f55c6e90d28b7
Autor:
Rachel Kelly, Andrew G. Cairns, Jörgen Ådén, Fredrik Almqvist, Alexis-Pierre Bemelmans, Emmanuel Brouillet, Tommy Patton, Declan P. McKernan, Eilís Dowd
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1685 (2021)
Animal models of Parkinson’s disease, in which the human α-synuclein transgene is overexpressed in the nigrostriatal pathway using viral vectors, are widely considered to be the most relevant models of the human condition. However, although highly
Externí odkaz:
https://doaj.org/article/c447a4e33b7344ddb7f816064af2a6e0
Publikováno v:
Arkivoc. 2020:365-378
Thiazolino ring fused 2-pyridones are a valuable scaffold with varied and substitution dependent biological activity, accessed primarily by an acyl ketene-imine cycloaddition and rearrangement. Although powerful, some aspects of this chemistry such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489e7aecc317161df408a78aa78a4ec5
https://doi.org/10.24820/ark.5550190.p011.445
https://doi.org/10.24820/ark.5550190.p011.445
Autor:
Tommy Patton, Alexis-Pierre Bemelmans, Emmanuel Brouillet, Andrew G. Cairns, Eilís Dowd, Declan P. McKernan, Fredrik Almqvist, Jörgen Ådén, Rachel Kelly
Publikováno v:
Biomolecules, Vol 11, Iss 1685, p 1685 (2021)
Biomolecules
Volume 11
Issue 11
Biomolecules
Volume 11
Issue 11
Animal models of Parkinson’s disease, in which the human α-synuclein transgene is overexpressed in the nigrostriatal pathway using viral vectors, are widely considered to be the most relevant models of the human condition. However, although highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d81754dedc871b05c8dfaae12b4fd77
https://www.mdpi.com/2218-273X/11/11/1685
https://www.mdpi.com/2218-273X/11/11/1685
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2275
Small molecules can be physicochemically targeted to the mitochondrial matrix using the lipophilic alkyltriphenylphosphonium (TPP) group. Once in the mitochondria the TPP conjugate can detect or influence processes within the mitochondrial matrix dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a25160160eb44df8106abff8ecfc62c
https://pubmed.ncbi.nlm.nih.gov/34118033
https://pubmed.ncbi.nlm.nih.gov/34118033
Publikováno v:
Organic Letters. 21:6946-6950
We report the synthesis of 6-arylthio-substituted-N-alkenyl 2-pyridones by ring opening of bicyclic thiazolino-2-pyridones with arynes. Varied functionalization was used to investigate scope and su ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877f48f7fd511566c6d592d744623ff3
https://doi.org/10.1021/acs.orglett.9b02549
https://doi.org/10.1021/acs.orglett.9b02549
Autor:
Andrew G. Cairns, Jörgen Ådén, Niamh Moriarty, Silvia Cabre, Laura K. Olsen, Fredrik Almqvist, Verónica Alamilla, Declan P. McKernan, Eilís Dowd
Publikováno v:
Brain, Behavior, and Immunity
Evidence is accumulating to suggest that viral infections and consequent viral-mediated neuroinflammation may contribute to the etiology of idiopathic Parkinson's disease. Moreover, viruses have been shown to influence α-synuclein oligomerization as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53644bfe9fde79a9edc2629702e37755
https://doi.org/10.1016/j.bbi.2019.04.036
https://doi.org/10.1016/j.bbi.2019.04.036
Autor:
Andrew G. Cairns, Dieter Söll, Alanna Schepartz, Scott J. Miller, Kyle S. Hoffman, Omer Ad, Aaron L. Featherston
Publikováno v:
ACS Central Science, Vol 5, Iss 7, Pp 1289-1294 (2019)
ACS central science, vol 5, iss 7
ACS central science, vol 5, iss 7
Here, we report that wild type Escherichia coli ribosomes accept and elongate precharged initiator tRNAs acylated with multiple benzoic acids, including aramid precursors, as well as malonyl (1,3-dicarbonyl) substrates to generate a diverse set of ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c88733cae1f9a5e3d5b3a2fbc81a67
https://doi.org/10.1021/acscentsci.9b00460
https://doi.org/10.1021/acscentsci.9b00460
Autor:
Martina Kulén, Christer Larsson, Fredrik Almqvist, K. Syam Krishnan, Erik Chorell, James A. D. Good, Mette R. Hansen, Gregory A. Harrison, Dennis X. Zhu, Jonathan Livny, Scott J. Hultgren, Kelly Flentie, Christina L. Stallings, Anders E. G. Lindgren, Leslie A. Weiss, Torbjörn Wixe, Hasan Tükenmez, Andrew G. Cairns, Christoffer Bengtsson, Souvik Sarkar, Samantha D. Solomon, Miranda E. Schene, Rachel L. Kinsella
Publikováno v:
Proceedings of the National Academy of Sciences. 116:10510-10517
Mycobacterium tuberculosis ( Mtb ) killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses imposed by the immune system and tolerate exposure to antibiotics, resulting in persistent inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc38cc536017cb4fd2b8f71cbd16357
https://doi.org/10.1073/pnas.1818009116
https://doi.org/10.1073/pnas.1818009116