Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Andrew G, Bowie"'
Autor:
Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M. Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M. Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I. Schmidt, Michael Way, Roland Rad, Andrew G. Bowie, Ulrike Protzer, Andreas Pichlmair
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a different disease manifestation de
Externí odkaz:
https://doaj.org/article/b2ed5b05f7224f76b575fd05ca07bceb
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109940- (2024)
Summary: SARM1 is a Toll-IL-1 receptor (TIR) domain-containing protein with roles in innate immunity and neuronal death in diverse organisms. Unlike other innate immune TIR proteins that function as adaptors for Toll-like receptors (TLRs), SARM1 has
Externí odkaz:
https://doaj.org/article/b9cd6b1ada9349c2a02f8782042eb623
Autor:
Xavier Martiáñez-Vendrell, Jonna Bloeme-ter Horst, Roy Hutchinson, Coralie Guy, Andrew G. Bowie, Marjolein Kikkert
Publikováno v:
Viruses, Vol 16, Iss 6, p 898 (2024)
Human coronavirus 229E (HCoV-229E) is associated with upper respiratory tract infections and generally causes mild respiratory symptoms. HCoV-229E infection can cause cell death, but the molecular pathways that lead to virus-induced cell death as wel
Externí odkaz:
https://doaj.org/article/8cd642843f9f48f68bae503d48bf3132
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107698- (2023)
Summary: Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate i
Externí odkaz:
https://doaj.org/article/a607ac954d334d5f9f7983df4f8ad153
Autor:
Marcin Baran, Claudia Feriotti, Aoife McGinley, Simon R. Carlile, Zhaozhao Jiang, Ricardo Calderon-Gonzalez, Amy Dumigan, Joana Sá-Pessoa, Caroline E. Sutton, Jay Kearney, Rachel M. McLoughlin, Kingston H.G. Mills, Katherine A. Fitzgerald, Jose A. Bengeochea, Andrew G. Bowie
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112341- (2023)
Summary: PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have been shown to regulate host gene expression through as-yet unclear mechanisms. We characterize mouse PYHIN IFI207, which we find is not involved in DNA sensing but ra
Externí odkaz:
https://doaj.org/article/f56f8dac50b94ee2b449ad3b6f42ddc8
Autor:
Lili Gu, David Casserly, Gareth Brady, Susan Carpenter, Adrian P. Bracken, Katherine A. Fitzgerald, Leonie Unterholzner, Andrew G. Bowie
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The interferon response is a critical component of the innate immune response. Here the authors implicate MNDA in the regulation of type I interferon responses to pathogen infection.
Externí odkaz:
https://doaj.org/article/ffe3c039477f4c9ea72af92f9863b298
Autor:
Yifat Ofir-Birin, Hila Ben Ami Pilo, Abel Cruz Camacho, Ariel Rudik, Anna Rivkin, Or-Yam Revach, Netta Nir, Tal Block Tamin, Paula Abou Karam, Edo Kiper, Yoav Peleg, Reinat Nevo, Aryeh Solomon, Tal Havkin-Solomon, Alicia Rojas, Ron Rotkopf, Ziv Porat, Dror Avni, Eli Schwartz, Thomas Zillinger, Gunther Hartmann, Antonella Di Pizio, Neils Ben Quashie, Rivka Dikstein, Motti Gerlic, Ana Claudia Torrecilhas, Carmit Levy, Esther N. M. Nolte-‘t Hoen, Andrew G. Bowie, Neta Regev-Rudzki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The chemokine CXCL10 is associated with pathogenesis of cerebral malaria in Plasmodium falciparum infection. Here the authors show that P. falciparum produces extracellular vesicles laden with RNAs that are taken up by monocytes resulting in a RIG-I
Externí odkaz:
https://doaj.org/article/224e6a94586f481d8f075fa74b8e8bf3
Autor:
Luke Gibbons, Ema Ozaki, Chris Greene, Anne Trappe, Michael Carty, Judith A. Coppinger, Andrew G. Bowie, Matthew Campbell, Sarah L. Doyle
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a role in induction of neuronal a
Externí odkaz:
https://doaj.org/article/6e62cc3d245341b18c752e2e3abf4cdc
Autor:
Saravjeet Singh, Sophie O’Reilly, Hossam Gewaid, Andrew G. Bowie, Virginie Gautier, D. Margaret Worrall
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12522 (2022)
The SARS-CoV-2 virus can utilize host cell proteases to facilitate cell entry, whereby the Spike (S) protein is cleaved at two specific sites to enable membrane fusion. Furin, transmembrane protease serine 2 (TMPRSS2), and cathepsin L (CatL) are the
Externí odkaz:
https://doaj.org/article/981ea2048cbc4519ae0e836e19ebe572
Autor:
Laura K. Finnegan, Naomi Chadderton, Paul F. Kenna, Arpad Palfi, Michael Carty, Andrew G. Bowie, Sophia Millington-Ward, G. Jane Farrar
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1606 (2022)
The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a gene-independent approach. Mitochondr
Externí odkaz:
https://doaj.org/article/866dbe1cf389426fb7897efaaefa3d0b