Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Andrew F. G. Quest"'
Autor:
Esteban Palacios, Lorena Lobos-González, Simón Guerrero, Marcelo J. Kogan, Baohai Shao, Jay W. Heinecke, Andrew F. G. Quest, Lisette Leyton, Manuel Valenzuela-Valderrama
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Helicobacter pylori (Hp) infects the stomach of 50% of the world’s population. Importantly, chronic infection by this bacterium correlates with the appearance of several extra-gastric pathologies, including neurodegenerative dis
Externí odkaz:
https://doaj.org/article/66bbe09056da4e25ada4d02743ecf618
Autor:
Lucas Yáñez, Cristopher Soto, Héctor Tapia, Martín Pacheco, Javiera Tapia, Gabriela Osses, Daniela Salinas, Victoria Rojas-Celis, Anilei Hoare, Andrew F. G. Quest, Jessica Díaz-Elizondo, José Manuel Pérez-Donoso, Denisse Bravo
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3611 (2024)
Periodontitis, characterized by persistent inflammation in the periodontium, is intricately connected to systemic diseases, including oral cancer. Bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, play a pivotal role in periodon
Externí odkaz:
https://doaj.org/article/2b46c3bc1327421091e223110d05c80d
Autor:
Ramón Pérez-Núñez, Alejandro Chamorro, María Fernanda González, Pamela Contreras, Rocío Artigas, Alejandro H. Corvalán, Brigitte van Zundert, Christopher Reyes, Pablo R. Moya, Ana María Avalos, Pascal Schneider, Andrew F. G. Quest, Lisette Leyton
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background In response to brain injury or inflammation, astrocytes undergo hypertrophy, proliferate, and migrate to the damaged zone. These changes, collectively known as "astrogliosis", initially protect the brain; however, astrogliosis can
Externí odkaz:
https://doaj.org/article/8f88a252b77145c0982c107e62d40b7f
Autor:
Lorena Lobos-González, Lorena Oróstica, Natalia Díaz-Valdivia, Victoria Rojas-Celis, America Campos, Eduardo Duran-Jara, Nicole Farfán, Lisette Leyton, Andrew F. G. Quest
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16947 (2023)
Caveolin-1 (CAV1) is a membrane-bound protein that suppresses tumor development yet also promotes metastasis. E-cadherin is important in CAV1-dependent tumor suppression and prevents CAV1-enhanced lung metastasis. Here, we used murine B16F10 and huma
Externí odkaz:
https://doaj.org/article/8cfcddb850ce4b739e93958ecd7a1548
Autor:
Antonio Hidalgo, Denisse Bravo, Cristopher Soto, Gabriela Maturana, Jimena Cordero-Machuca, María Carolina Zúñiga-López, Felipe Oyarzun-Ampuero, Andrew F. G. Quest
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1866 (2023)
The bacterium Helicobacter pylori (H. pylori) represents a major risk factor associated with the development of gastric cancer. The anti-oxidant curcumin has been ascribed many benefits to human health, including bactericidal effects. However, these
Externí odkaz:
https://doaj.org/article/b9b23775041744109deb23149b063c41
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1734 (2023)
Mitochondrial dysfunction is an interesting therapeutic target to help reduce cancer deaths, and the use of bioactive compounds has emerged as a novel and safe approach to solve this problem. Here, we discuss the information available related to phlo
Externí odkaz:
https://doaj.org/article/b07abdadf30d49eca77603a93871b075
Autor:
María Fernanda González, Renato Burgos-Ravanal, Baohai Shao, Jay Heinecke, Manuel Valenzuela-Valderrama, Alejandro H. Corvalán, Andrew F. G. Quest
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chronic Helicobacter pylori (H. pylori) infection is considered the main risk factor for the development of gastric cancer. Pathophysiological changes in the gastric mucosa initiated by this bacterium can persist even after pharmacological eradicatio
Externí odkaz:
https://doaj.org/article/488bcf524d3f4e94a510c9ff0faa32da
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Advances in our understanding of cancer biology have contributed to generating different treatments to improve the survival of cancer patients. However, although initially most of the therapies are effective, relapse and recurrence occur in a large p
Externí odkaz:
https://doaj.org/article/51e8dc3b190a4d1aa9b86412793c1102
Autor:
Solange Rivas, Patricio Silva, Montserrat Reyes, Hugo Sepúlveda, Luis Solano, Juan Acuña, Marisol Guerrero, Manuel Varas-Godoy, Andrew F. G. Quest, Martín Montecino, Vicente A. Torres
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and invasion, and that
Externí odkaz:
https://doaj.org/article/162d2f8285b346ffa6b8d60dcfde1d70
Autor:
Isabel Castro, Patricia Carvajal, Daniela Jara, Sergio Aguilera, Benjamín Heathcote, María-José Barrera, Víctor Aliaga-Tobar, Vinicius Maracaja-Coutinho, Ulises Urzúa, Andrew F. G. Quest, Sergio González, Claudio Molina, Marcela Hermoso, María-Julieta González
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
MicroRNAs (miRNAs) are small non-coding RNAs (sRNA), that alter gene expression by binding to target messenger RNAs (mRNAs) and repressing translation. Dysregulated miRNA expression has been implicated in the pathogenesis of autoimmune diseases such
Externí odkaz:
https://doaj.org/article/8a559b3414b648fc8c014a072e3c39dc