Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Andrew Eatherton"'
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Autor:
Jason G, Kettle, Sharan K, Bagal, Sue, Bickerton, Michael S, Bodnarchuk, Scott, Boyd, Jason, Breed, Rodrigo J, Carbajo, Doyle J, Cassar, Atanu, Chakraborty, Sabina, Cosulich, Iain, Cumming, Michael, Davies, Nichola L, Davies, Andrew, Eatherton, Laura, Evans, Lyman, Feron, Shaun, Fillery, Emma S, Gleave, Frederick W, Goldberg, Lyndsey, Hanson, Stephanie, Harlfinger, Martin, Howard, Rachel, Howells, Anne, Jackson, Paul, Kemmitt, Gillian, Lamont, Scott, Lamont, Hilary J, Lewis, Libin, Liu, Michael J, Niedbala, Christopher, Phillips, Radek, Polanski, Piotr, Raubo, Graeme, Robb, David M, Robinson, Sarah, Ross, Matthew G, Sanders, Michael, Tonge, Rebecca, Whiteley, Stephen, Wilkinson, Junsheng, Yang, Wenman, Zhang
Publikováno v:
Journal of medicinal chemistry. 65(9)
KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now rendered this important GTPase druggable. Herein, we report our structure-based drug design appro
Autor:
Jason G, Kettle, Sharan K, Bagal, Sue, Bickerton, Michael S, Bodnarchuk, Jason, Breed, Rodrigo J, Carbajo, Doyle J, Cassar, Atanu, Chakraborty, Sabina, Cosulich, Iain, Cumming, Michael, Davies, Andrew, Eatherton, Laura, Evans, Lyman, Feron, Shaun, Fillery, Emma S, Gleave, Frederick W, Goldberg, Stephanie, Harlfinger, Lyndsey, Hanson, Martin, Howard, Rachel, Howells, Anne, Jackson, Paul, Kemmitt, Jennifer K, Kingston, Scott, Lamont, Hilary J, Lewis, Songlei, Li, Libin, Liu, Derek, Ogg, Christopher, Phillips, Radek, Polanski, Graeme, Robb, David, Robinson, Sarah, Ross, James M, Smith, Michael, Tonge, Rebecca, Whiteley, Junsheng, Yang, Longfei, Zhang, Xiliang, Zhao
Publikováno v:
Journal of medicinal chemistry. 63(9)
Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS
Publikováno v:
Synlett. :684-687
4,5-Substituted cyclohexanone 10 and its derivatives are carbocyclic analogues of Indinavir 3 and are expected to have antiviral activity. Early attempts to obtain these compounds via a diastereoselective [3+2] cycloaddition between 19 and 14 failed
Autor:
Andrew Eatherton, William Watson, Jenny C. Gilbert, Emmanuel Hubert Demont, Sally Redshaw, Peter Crackett, Christopher S. Frampton, Irfan Kahn
Publikováno v:
Synlett. :679-683
α,β-Unsaturated chiral oxazolidinone 10 can be smoothly obtained from the corresponding aldehyde 14 under Masamune-Roush conditions. Oxazolidinone 10 reacts diastereoselectively with diene 14 under lewis acid catalysis which allows the synthesis of
Autor:
Zehong Wan, Adrian Hall, Yun Jin, Jia-Ning Xiang, Eric Yang, Andrew Eatherton, Beverley Smith, Guang Yang, Haihua Yu, Ju Wang, Liang Ye, Lit-Fui Lau, Ting Yang, William Mitchell, Wei Cai, Xiaomin Zhang, Yingxia Sang, Yonghui Wang, Zhaolong Tong, Ziqiang Cheng, Ishrut Hussain, John D. Elliott, Yasuji Matsuoka
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(13)
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthe