Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Andrew E. Timms"'
Autor:
Denise L. Cecil, Benjamin Curtis, Ekram Gad, Michael Gormley, Andrew E. Timms, Lauren Corulli, Rinke Bos, Rajendra N. Damle, Manuel A. Sepulveda, Mary L. Disis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Prostate cancer is one of the few malignancies that includes vaccination as a treatment modality. Elements of an effective cancer vaccine should include the ability to elicit a Type I T-cell response and target multiple antigenic proteins ex
Externí odkaz:
https://doaj.org/article/747694e3df3f4e66a2c860aa790fac69
Autor:
Andrew T. Timberlake, Casey Griffin, Carrie L. Heike, Anne V. Hing, Michael L. Cunningham, David Chitayat, Mark R. Davis, Soghra J. Doust, Amelia F. Drake, Milagros M. Duenas-Roque, Jack Goldblatt, Jonas A. Gustafson, Paula Hurtado-Villa, Alexis Johns, Natalya Karp, Nigel G. Laing, Leanne Magee, University of Washington Center for Mendelian Genomics, Sureni V. Mullegama, Harry Pachajoa, Gloria L. Porras-Hurtado, Rhonda E. Schnur, Jennie Slee, Steven L. Singer, David A. Staffenberg, Andrew E. Timms, Cheryl A. Wise, Ignacio Zarante, Jean-Pierre Saint-Jeannet, Daniela V. Luquetti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Despite being a common congenital facial anomaly, the genetic etiology of craniofacial microsomia (CFM) is not well understood. Here, the authors use exome and genome sequencing of 146 individuals with CFM to identify haploinsufficient variants in SF
Externí odkaz:
https://doaj.org/article/d765e285eeb1444f96c9860e6bc243dd
Autor:
Samantha Lapehn, Jonas A. Gustafson, Andrew E. Timms, Michael L. Cunningham, Alison G. Paquette
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5353 (2023)
Craniosynostosis is a birth defect where calvarial sutures close prematurely, as part of a genetic syndrome or independently, with unknown cause. This study aimed to identify differences in gene expression in primary calvarial cell lines derived from
Externí odkaz:
https://doaj.org/article/e3770efabc9440d5a53dcb90b4f2884d
Autor:
Pin Lyu, Thanh Hoang, Clayton P. Santiago, Eric D. Thomas, Andrew E. Timms, Haley Appel, Megan Gimmen, Nguyet Le, Lizhi Jiang, Dong Won Kim, Siqi Chen, David F. Espinoza, Ariel E. Telger, Kurt Weir, Brian S. Clark, Timothy J. Cherry, Jiang Qian, Seth Blackshaw
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 109994- (2021)
Summary: Gene regulatory networks (GRNs), consisting of transcription factors and their target sites, control neurogenesis and cell-fate specification in the developing central nervous system. In this study, we use integrated single-cell RNA and sing
Externí odkaz:
https://doaj.org/article/bb845b0091334d5fbe14f15fb9a4f379
Autor:
Daryl M. Okamura, Chris M. Brewer, Paul Wakenight, Nadia Bahrami, Kristina Bernardi, Amy Tran, Jill Olson, Xiaogang Shi, Szu-Ying Yeh, Adrian Piliponsky, Sarah J. Collins, Elizabeth D. Nguyen, Andrew E. Timms, James W. MacDonald, Theo K. Bammler, Branden R. Nelson, Kathleen J. Millen, David R. Beier, Mark W. Majesky
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103269- (2021)
Summary: Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal orga
Externí odkaz:
https://doaj.org/article/14339f301a224e7fbcad8ed0416f3953
Autor:
Daniela V. Luquetti, Carrie L. Heike, Ignacio Zarante, Andrew E. Timms, Jonas Gustafson, Harry Pachajoa, Gloria L. Porras‐Hurtado, Paola Ayala‐Ramirez, Milagros M. Duenas‐Roque, Natalia Jimenez, Lina M. Ibanez, Paula Hurtado‐Villa
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Abstract Background Craniofacial microsomia (CFM), also known as the oculo‐auriculo‐vertebral spectrum, comprises a variable phenotype with the most common features including microtia and mandibular hypoplasia on one or both sides, in addition to
Externí odkaz:
https://doaj.org/article/ac22a56482324882a03a2f67acf1ced2
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 401-409 (2018)
Positional cloning of ENU-induced mutations has traditionally relied on analysis of polymorphic variation between two strains. In contrast, the application of whole-genome sequencing (WGS) has enabled gene discovery in mutant lines maintained on an i
Externí odkaz:
https://doaj.org/article/a3b72831dd454ce8b7b0edc84f8b4d2f
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 8, Pp 2479-2487 (2016)
We have previously described a forward genetic screen in mice for abnormalities of brain development. Characterization of two hydrocephalus mutants by whole-exome sequencing after whole-genome SNP mapping revealed novel recessive mutations in Dnaaf1
Externí odkaz:
https://doaj.org/article/119be42d738f4e0ba4dc954442a14389
Autor:
Mary L. Disis, Erin Rodmaker, Lauren R. Corulli, Elliot A. Hershberg, Andrew E. Timms, Piper M. Treuting, Ekram A. Gad, Laura Riolobos
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747942e75c730900ef9168da0f428812
https://doi.org/10.1158/1940-6207.22534501
https://doi.org/10.1158/1940-6207.22534501
Autor:
Mary L. Disis, Erin Rodmaker, Lauren R. Corulli, Elliot A. Hershberg, Andrew E. Timms, Piper M. Treuting, Ekram A. Gad, Laura Riolobos
Supplementary Table S1. Weight changes in different treatment groups for each mouse strain. Supplementary Table S2. Weight change in NTCU treated mice is sex independent. Supplementary Table S3. Survival in NTCU treated mice is sex independent. Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a401f2ccb8707586e4da20cabb05dd07
https://doi.org/10.1158/1940-6207.22534498
https://doi.org/10.1158/1940-6207.22534498