Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Andrew E. Parker"'
Autor:
Hélène Asnagli, Norbert Minet, Christina Pfeiffer, Eef Hoeben, Rebecca Lane, David Laughton, Louise Birch, Geraint Jones, Andrew Novak, Andrew E. Parker, Heinz Ludwig, Alain Fischer, Sylvain Latour, Philip A. Beer
Publikováno v:
HemaSphere, Vol 7, Iss 4, p e864 (2023)
Lymphoma is the most common hematological malignancy and is among the 10 most prevalent cancers worldwide. Although survival has been improved by modern immunochemotherapeutic regimens, there remains a significant need for novel targeted agents to tr
Externí odkaz:
https://doaj.org/article/94c683a95284402c9f04f59bf749bdad
Autor:
Philipp M. Lepper, Martha Triantafilou, Luke A. O'Neill, Natalija Novak, Hermann Wagner, Andrew E. Parker, Kathy Triantafilou
Publikováno v:
Mediators of Inflammation, Vol 2010 (2010)
Externí odkaz:
https://doaj.org/article/be76b1be66c14f01b88474cad75f4be5
Autor:
Kazuhiro Yamamoto, Kathryn Owen, Jayesh Dudhia, Dudley K. Strickland, Linda Troeberg, Andrew E. Parker, Hideaki Nagase, Simone D. Scilabra
Publikováno v:
Journal of Biological Chemistry. 289:6462-6474
Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e410f3de03a0509a350b0d8764a39b7f
https://doi.org/10.1074/jbc.m113.545376
https://doi.org/10.1074/jbc.m113.545376
Autor:
Steven H. Sacks, Aisling O'Shaughnessy, Andrew E. Parker, Mary Reilly, Conrad A. Farrar, Brian Keogh, William McCormack
Publikováno v:
The FASEB Journal. 26:799-807
Toll-like receptors (TLRs) are important molecules involved in the activation of innate and subsequent development of adaptive immunity. TLRs are ligated by exogenous ligands from pathogens and by endogenous ligands released in inflammatory diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b402e9fba7cb4c914212a3499fc522d
https://doi.org/10.1096/fj.11-195396
https://doi.org/10.1096/fj.11-195396
Autor:
John Wardale, Jonathan Tart, Kristen M. Clements, Jim Freeth, Jo K Flannelly, Peter Newham, S.M. Brockbank, Andrew E. Parker
Publikováno v:
Annals of the Rheumatic Diseases. 70:683-689
ObjectiveAggrecan is a critical component of cartilage extracellular matrix. Several members of the ‘a disintegrin and metalloproteinase with thrombospondin motifs’ (ADAMTS) family have been characterised as aggrecanases by their ability to gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761b77341ea57d9f536bf6e11488ab37
https://doi.org/10.1136/ard.2010.130757
https://doi.org/10.1136/ard.2010.130757
Autor:
David Young, Andrew E. Parker, K.L. Culley, Ian M. Clark, Tracey E. Swingler, Sara A. Illman, Jouko Lohi, Lara Kevorkian
Publikováno v:
Biochemical Journal. 427:391-400
MMP-28 (epilysin) is a recently cloned member of the MMP (matrix metalloproteinase) family. It is highly expressed in the skin by keratinocytes, the developing and regenerating nervous system and a number of other normal human tissues, as well as a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75669b7b41c5c73bf031a253fda67a6e
https://doi.org/10.1042/bj20091798
https://doi.org/10.1042/bj20091798
Publikováno v:
Nature Reviews Drug Discovery. 9:293-307
There is a growing interest in the targeting of Toll-like receptors (TLRs) for the prevention and treatment of cancer, rheumatoid arthritis, inflammatory bowel disease and systemic lupus erythematosus (SLE). Several new compounds are now undergoing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35040a7255af9b67558750645c2f035
https://doi.org/10.1038/nrd3203
https://doi.org/10.1038/nrd3203
Autor:
Mary B. Goldring, Ursula R. Rodgers, Alison K. Surridge, Ian M. Clark, R. Norton, Jasmine G. Waters, Andrew E. Parker, Tracey E. Swingler, Rose K Davidson, Lara Kevorkian
Publikováno v:
Matrix Biology
The ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) family includes 19 secreted proteinases in man. ADAMTS16 is a recently cloned gene expressed at high levels in fetal lung and kidney and adult brain and ovary. The ADA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f55d9ab6bee70b771e75ad885e30eef
Autor:
Andrew E. Parker, Dylan R. Edwards, Simon T. Donell, Lara Kevorkian, Sarah Porter, Ian M. Clark, David Young, Lee Shepstone, C. Darrah, S.M. Brockbank
Publikováno v:
Arthritis & Rheumatism. 50:131-141
Objective To profile the expression of all known members of the matrix metalloproteinase (MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal cartilage and cartilage from patients with osteoarthritis (OA). Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee9239fa93fb03ab01d3872387c00a1
https://doi.org/10.1002/art.11433
https://doi.org/10.1002/art.11433
Publikováno v:
Molecular and Cellular Biology. 17:2381-2390
Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein present in all eukaryotes. In vitro studies have implicated RPA in simian virus 40 DNA synthesis and nucleotide excision repair, but little direct information is avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be4957c6d9e323f3e11abad319f2f3c
https://doi.org/10.1128/mcb.17.5.2381
https://doi.org/10.1128/mcb.17.5.2381