Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Andrew E. Nixon"'
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Akademický článek
In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering
Autor: Yvett Sosa, Bhav Kapur, Jessica Hurtak, Laura J. Kingsley, Hao Wu, Stefanie Gruber, Herbert Nar, Saad Khattabi, Jesus Seco Moral, Maria Fátima Lucas, Caterina Martin, Nikola Lončar, Frederic Buono, Noah Pefaur, Andrew E. Nixon, Jinhua J. Song
Publikováno v: Frontiers in Chemical Biology, Vol 3 (2024)
Introduction: Biocatalysis, particularly through engineered enzymes, presents a cost-effective, efficient, and eco-friendly approach to compound synthesis. We sought to identify ketoreductases capable of synthesizing optically pure alcohols or ketone
Externí odkaz: https://doaj.org/article/9cf8af4a995a453ca62582f81e558283
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2
Akademický článek
How can we discover developable antibody-based biotherapeutics?
Autor: Joschka Bauer, Nandhini Rajagopal, Priyanka Gupta, Pankaj Gupta, Andrew E. Nixon, Sandeep Kumar
Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)
Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals despite significant challenges and risks to their discovery and development. This review discusses the most frequently encountered hurdles in the research and develo
Externí odkaz: https://doaj.org/article/7cdbcabaecc84b5eabb91c988ce1f033
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3
Akademický článek
An adapted consensus protein design strategy for identifying globally optimal biotherapeutics
Autor: Yanyun Liu, Kenny Tsang, Michelle Mays, Gale Hansen, Jeffrey Chiecko, Maureen Crames, Yangjie Wei, Weijie Zhou, Chase Fredrick, James Hu, Dongmei Liu, Douglas Gebhard, Zhong-Fu Huang, Akshita Datar, Anthony Kronkaitis, Kristina Gueneva-Boucheva, Daniel Seeliger, Fei Han, Saurabh Sen, Srinath Kasturirangan, Justin M. Scheer, Andrew E. Nixon, Tadas Panavas, Michael S. Marlow, Sandeep Kumar
Publikováno v: mAbs, Vol 14, Iss 1 (2022)
Biotherapeutic optimization, whether to improve general properties or to engineer specific attributes, is a time-consuming process with uncertain outcomes. Conversely, Consensus Protein Design has been shown to be a viable approach to enhance protein
Externí odkaz: https://doaj.org/article/4c91351f25cc410584aa768aeb4853a4
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4
Akademický článek
Discovery Strategies to Maximize the Clinical Potential of T-Cell Engaging Antibodies for the Treatment of Solid Tumors
Autor: Vladimir Voynov, Paul J. Adam, Andrew E. Nixon, Justin M. Scheer
Publikováno v: Antibodies, Vol 9, Iss 4, p 65 (2020)
T-cell Engaging bispecific antibodies (TcEs) that can re-direct cytotoxic T-cells to kill cancer cells have been validated in clinical studies. To date, the clinical success with these agents has mainly been seen in hematologic tumor indications. How
Externí odkaz: https://doaj.org/article/e2d56adc7fe64fd6a72748680d8fff3e
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5
Data from A Bispecific DLL3/CD3 IgG-Like T-Cell Engaging Antibody Induces Antitumor Responses in Small Cell Lung Cancer
Autor: Paul J. Adam, Justin M. Scheer, Andrew E. Nixon, Francesca Trapani, Craig Giragossian, Barbara Drobits-Handl, Vladimir Voynov, Susanne Hipp
Purpose:Small cell lung cancer (SCLC) is the most lethal and aggressive subtype of lung carcinoma characterized by highly chemotherapy-resistant recurrence in the majority of patients. To effectively treat SCLC, we have developed a unique and novel I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ec8681e88494e3f0566fefc32aeffd
https://doi.org/10.1158/1078-0432.c.6529409
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10
Intrinsic physicochemical profile of marketed antibody-based biotherapeutics
Autor: Sandeep Kumar, Priyanka Gupta, Lucky Ahmed, Andrew E. Nixon, Justin Scheer, Kyle P. Martin
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance Successful biologic drug discovery and development involves finding functional as well as developable candidates. Once a candidate has been demonstrated to be functional, the next step is to determine whether it can be translated into a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f38819b8220131d49f2fe25f9d5d9e
https://pubmed.ncbi.nlm.nih.gov/34504010
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