Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation.

Autor: Ana L Alessandri, Rodger Duffin, Andrew E Leitch, Christopher D Lucas, Tara A Sheldrake, David A Dorward, Nik Hirani, Vanessa Pinho, Lirlândia Pires de Sousa, Mauro M Teixeira, John F Lyons, Christopher Haslett, Adriano G Rossi

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25683 (2011)

Eosinophils not only defend the body against parasitic infection but are also involved in pathological inflammatory allergic diseases such as asthma, allergic rhinitis and contact dermatitis. Clearance of apoptotic eosinophils by macrophages is a key

Externí odkaz: https://doaj.org/article/c1a3b7d4cbea493cac69e41a520b8a9c

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

Autor: Andrew E. Leitch, Adriano G. Rossi, Christopher Haslett

Publikováno v: British Journal of Pharmacology. 158:1004-1016

The cyclin-dependent kinase inhibitor (CDKi) drugs such as R-roscovitine have emerged as potential anti-inflammatory, pharmacological agents that can influence the resolution of inflammation. Usually, once an inciting inflammatory stimulus has been e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdb63ff1b663378c57225d73f56fecd3
https://doi.org/10.1111/j.1476-5381.2009.00402.x

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

Autor: Andrew E. Leitch, John A. Marwick, Rodger Duffin, Adriano G. Rossi, Christopher D. Lucas, Christopher Haslett

Publikováno v: Leitch, A E, Lucas, C, Marwick, J A, Duffin, R, Haslett, C & Rossi, A G 2012, ' Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation ', Cell Death and Differentiation, vol. 19, no. 12, pp. 1950-1961 . https://doi.org/10.1038/cdd.2012.80
Cell Death and Differentiation

Terminally differentiated neutrophils are short-lived but the key effector cells of the innate immune response, and have a prominent role in the pathogenesis and propagation of many inflammatory diseases. Delayed apoptosis, which is responsible for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f408da14f5301b12aaaacef72a8361a7
https://www.pure.ed.ac.uk/ws/files/10176137/cdd_2012.pdf

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

Autor: Andrew E, Leitch, Nicola A, Riley, Tara A, Sheldrake, Michela, Festa, Sarah, Fox, Rodger, Duffin, Christopher, Haslett, Adriano G, Rossi

Publikováno v: European journal of immunology. 40(4)

Successful resolution of inflammation requires inflammatory cells such as neutrophils to undergo apoptosis prior to non-inflammatory phagocytosis by professional phagocytes. Recently, cyclin-dependent kinase (CDK) inhibitors (e.g. R-roscovitine) have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::603e16297f751a3aa8ca2bbb9a34e2b3
https://pubmed.ncbi.nlm.nih.gov/20127676

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

Autor: Ana L. Alessandri, Adriano G. Rossi, Hugh J.M. Brady, John M. Hallett, Rodger Duffin, Mauro M. Teixeira, Sarah Fox, Tara A. Sheldrake, Morag C. Martin, Colette Meyer, Christopher Haslett, Andrew E. Leitch, Ian Dransfield

Publikováno v: FEBS letters. 583(15)

Eosinophils are major players in inflammatory allergic diseases such as asthma, hay fever and eczema. Here we show that the cyclin-dependent kinase inhibitor (CDKi) R-roscovitine efficiently and rapidly induces human eosinophil apoptosis using flow c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c936692fb9b5d13edff5a5963ea2c0
https://pubmed.ncbi.nlm.nih.gov/19616548