Výsledky vyhledávání - "Andrew E. Hale"

Akademický článek

Engineering highly efficient backsplicing and translation of synthetic circRNAs

Autor: Rita M. Meganck, Jiacheng Liu, Andrew E. Hale, Katherine E. Simon, Marco M. Fanous, Heather A. Vincent, Jeremy E. Wilusz, Nathaniel J. Moorman, William F. Marzluff, Aravind Asokan

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 821-834 (2021)

Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for expression of therapeutic proteins and non-coding RNAs. In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing. Here, we inter

Externí odkaz: https://doaj.org/article/010d4637b6644616b9a2c316a95f48a2

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Akademický článek

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

Autor: Vineet D. Menachery, Hugh D. Mitchell, Adam S. Cockrell, Lisa E. Gralinski, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Madeline G. Douglas, Trevor Scobey, Anne Beall, Kenneth Dinnon, Jacob F. Kocher, Andrew E. Hale, Kelly G. Stratton, Katrina M. Waters, Ralph S. Baric

Publikováno v: mBio, Vol 8, Iss 4 (2017)

ABSTRACT While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of a

Externí odkaz: https://doaj.org/article/438eeeef29a24edba2f4d738b85fb4c0

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The Ends Dictate the Means: Promoter Switching in Herpesvirus Gene Expression

Autor: Nathaniel J. Moorman, Andrew E. Hale

Publikováno v: Annual Review of Virology. 8:201-218

Herpesvirus gene expression is dynamic and complex, with distinct complements of viral genes expressed at specific times in different infection contexts. These complex patterns of viral gene expression arise in part from the integration of multiple c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e0b7834a8bd8cb1bc85ed8a6f39d7f
https://doi.org/10.1146/annurev-virology-091919-072841

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Akademický článek

Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 6, Pp 695-713 (2015)

Abstract Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in v

Externí odkaz: https://doaj.org/article/2ba2fa97eac5474ab7e2db24f409a724

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Engineering highly efficient backsplicing and translation of synthetic circRNAs

Autor: Andrew E. Hale, Katherine E. Simon, William F. Marzluff, Rita M. Meganck, Jeremy E. Wilusz, Jiacheng Liu, Nathaniel J. Moorman, Aravind Asokan, Heather A. Vincent, Marco M. Fanous

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 821-834 (2021)
Molecular Therapy. Nucleic Acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d39cea54c678256b7578d7a49d26b5f
http://www.sciencedirect.com/science/article/pii/S2162253121000032

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FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation

Autor: Andrew E. Hale, Nathaniel J. Moorman, Suzu Igarashi, Erik M. Lenarcic, Jeremy P. Kamil, Felicia Goodrum, Donna Collins-McMillen

Publikováno v: Proc Natl Acad Sci U S A

Human progenitor cells (HPCs) support human cytomegalovirus (HCMV) latency, and their differentiation along the myeloid lineage triggers cellular cues that drive reactivation. A key step during HCMV reactivation in latently infected HPCs is reexpress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d87c4b665009cc2054106116609ba91
https://doi.org/10.1073/pnas.2002651117

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FOXO Transcription Factors Activate Alternative Major Immediate Early Promoters to Induce Human Cytomegalovirus Reactivation

Autor: Donna Collins-McMillen, Felicia Goodrum, Nathaniel J. Moorman, Erik M. Lenarcic, Jeremy P. Kamil, Andrew E. Hale

A key step during viral reactivation from latency is the re-expression of viral genes. Hematopoietic progenitor cells (HPCs) support human cytomegalovirus (HCMV) latency, and their differentiation triggers cellular cues that drive reactivation. A key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbb29493594603da7332ac58dd130eb
https://doi.org/10.1101/2020.02.10.942433

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Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection

Autor: Barney S. Graham, Andrew E. Hale, Lingshu Wang, Ralph S. Baric, Lisa E. Gralinski, Kenneth H. Dinnon, Vineet D. Menachery, Eileen T. McAnarney, W. Ian Lipkin, Trevor Scobey, Boyd Yount, Simon J. Anthony, Scott H. Randell, Rachel L. Graham

Publikováno v: Journal of Virology

Overall, our studies demonstrate that proteolytic cleavage is the primary barrier to infection for a subset of zoonotic coronaviruses. Moving forward, the results argue that both receptor binding and proteolytic cleavage of the spike are critical fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768cb7b13688657906dfb2d5e7cbd855
http://europepmc.org/articles/PMC7022341

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Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

Autor: Seth J. Weir, Tigist Y. Tamir, Priscila F. Siesser, Bernard E. Weissman, Trent Stohrer, M. Ben Major, Dennis Goldfarb, Brittany M. Bowman, Ryan M. Murphy, Kyle M. LaPak, Travis P. Schrank, Andrew E. Hale, Megan J. Agajanian, Nathaniel J. Moorman

Publikováno v: J Cell Sci

Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is a transcription factor and master regulator of cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, but conversely NRF2 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893daee48fa4a46cf754fb568779223d
https://pubmed.ncbi.nlm.nih.gov/32546533

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