Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andrew E. Douglas"'
Autor:
Dasa Lipovsek, Andrew E Douglas, Mary J. Harner, Michael A. Poss, Fei Yu, Chi-Wang Lin, Joanna F. Swain, Ving G. Lee, Virginie Lafont, Martin C. Wright
Publikováno v:
Angewandte Chemie (International Ed. in English)
Recent improvements in mRNA display have enabled the selection of peptides that incorporate non‐natural amino acids, thus expanding the chemical diversity of macrocycles beyond what is accessible in nature. Such libraries have incorporated non‐na
Autor:
Chi‐Wang Lin, Mary J. Harner, Andrew E. Douglas, Virginie Lafont, Fei Yu, Ving G. Lee, Michael A. Poss, Joanna F. Swain, Martin Wright, Daša Lipovšek
Publikováno v:
Angewandte Chemie. 133
Autor:
Chi‐Wang Lin, Mary J. Harner, Andrew E. Douglas, Virginie Lafont, Fei Yu, Ving G. Lee, Michael A. Poss, Joanna F. Swain, Martin Wright, Daša Lipovšek
Publikováno v:
Angewandte Chemie International Edition. 60
Autor:
Charu Chaudhry, Ping Zhang, Kyoung S. Kim, William J. Pitts, Cornelius Lyndon A M, Lynn M. Abell, Hart Amy C, Kevin O’Malley, Junqing Guo, Brian Carpenter, Hao Lu, Ramesh Padmanabha, Patrick J. Shaw, Mertzman Michael E, Kevin Kish, Andrew E Douglas, Matthew Pokross, John E. Macor, Deepa Calambur, Carolyn A. Weigelt
Publikováno v:
ACS Med Chem Lett
[Image: see text] Necroptosis has been implicated in a variety of disease states, and RIPK3 is one of the kinases identified to play a critical role in this signaling pathway. In an effort to identify RIPK3 kinase inhibitors with a novel profile, mec
Autor:
William J. Metzler, Luciano Mueller, Yaqun Zhang, Mian Gao, Nicolas Szapiel, Mark R. Witmer, David Hedin, Deepa Calambur, Dianlin Xie, Hui Wei, Frank Marsilio, Andrew E Douglas, Ping Zhang
Publikováno v:
Journal of Biomolecular NMR. 68:237-247
An improved expression protocol is proposed for amino acid type-specific [13C], [15N]-isotope labeling of proteins in baculovirus-infected (BV) insect cell cultures. This new protocol modifies the methods published by Gossert et al. (J Biomol NMR 51(
Publikováno v:
Molecular Pharmacology. 83:691-697
Smoothened (Smo) is a 7-transmembrane protein essential to the activation of Gli transcription factors (Gli) by hedgehog morphogens. The structure of Smo implies interactions with heterotrimeric G proteins, but the degree to which G proteins particip
Autor:
Feng Shen, Natalia A. Riobo, Andrew E. Douglas, Martin E. Fernandez-Zapico, David R. Manning, Jennifer A. Heim, Luciana L. Almada
Publikováno v:
Journal of Biological Chemistry. 286:30714-30722
Smoothened (Smo) is a seven-transmembrane (7-TM) receptor that is essential to most actions of the Hedgehog family of morphogens. We found previously that Smo couples to members of the G(i) family of heterotrimeric G proteins, which in some cases are
Publikováno v:
Protein science : a publication of the Protein Society. 16(4)
Apoptosis of virally infected cells is an innate host mechanism used to prevent viral spread. However, viruses have evolved a number of proteins that function to modulate the apoptotic cascades and thereby favor productive viral replication. One such