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Autor:
Andrew E. Czezel, Erika nemes, Sarolta Gundy, Csaba Elek, Aadre Reis, Julia Metneki, Karl Sperling, Gábor E. Tusnády, Zoltan Viragh, László Tímár
Publikováno v:
The Lancet. 341:539-542
Of 15 live births in one Hungarian village in 1989-90, 11 (73%) were affected by congenital abnormalities and 6 were twins. Of the 11, 4 had Down syndrome. Likely causes of such clusters (known teratogenic factors, familial inheritance, consanguinity