Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Andrew E. Arrant"'
Autor:
Anna K. Cook, Kelsey M. Greathouse, Phaedra N. Manuel, Noelle H. Cooper, Juliana M. Eberhardt, Cameron D. Freeman, Audrey J. Weber, Jeremy H. Herskowitz, Andrew E. Arrant
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Loss-of-function mutations in the progranulin (GRN) gene are an autosomal dominant cause of Frontotemporal Dementia (FTD). These mutations typically result in haploinsufficiency of the progranulin protein. Grn +/– mice provide a model for
Externí odkaz:
https://doaj.org/article/dcc01e54cc45449c9600e182fdd786bb
Autor:
Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long, Arnon Rosenthal
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone, immune regulator, and
Externí odkaz:
https://doaj.org/article/b2df0fda23a94d45afa816e976160d6e
Autor:
Azariah K. Kaplelach, Stephanie N. Fox, Anna K. Cook, Justin A. Hall, Ryan S. Dannemiller, Karen L. Jaunarajs, Andrew E. Arrant
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106326- (2023)
Progranulin is a secreted pro-protein that has anti-inflammatory and neurotrophic effects and is necessary for maintaining lysosomal function. Mutations in progranulin (GRN) are a major cause of frontotemporal dementia. Most pathogenic GRN mutations
Externí odkaz:
https://doaj.org/article/52572181a12143e1a164172327fe3964
Autor:
Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) develop frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD
Externí odkaz:
https://doaj.org/article/cb7d9e8149f4472c81b6d7612826356c
Autor:
Andrew E. Arrant, Jonathan R. Roth, Nicholas R. Boyle, Shreya N. Kashyap, Madelyn Q. Hoffmann, Charles F. Murchison, Eliana Marisa Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Erik D. Roberson
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN
Externí odkaz:
https://doaj.org/article/c318266701f74db1b7c84975e46849dc
Autor:
Andrew E. Arrant, Anthony J. Filiano, Aashka R. Patel, Madelyn Q. Hoffmann, Nicholas R. Boyle, Shreya N. Kashyap, Vincent C. Onyilo, Allen H. Young, Erik D. Roberson
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 152-162 (2019)
Loss-of-function mutations in progranulin (GRN), most of which cause progranulin haploinsufficiency, are a major autosomal dominant cause of frontotemporal dementia (FTD). Individuals with loss-of-function mutations on both GRN alleles develop neuron
Externí odkaz:
https://doaj.org/article/97e61d56e52648b9bc2c109597052725
Autor:
Lindsay E. Stoyka, Andrew E. Arrant, Drake R. Thrasher, Dreson L. Russell, Jennifer Freire, Casey L. Mahoney, Ashwin Narayanan, Aseel G. Dib, David G. Standaert, Laura A. Volpicelli-Daley
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Parkinson's disease (PD) is defined by motor symptoms such as tremor at rest, bradykinesia, postural instability, and stiffness. In addition to the classical motor defects that define PD, up to 80% of patients experience cognitive changes and psychia
Externí odkaz:
https://doaj.org/article/9833562d2ac34b90abc212b46135599b
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Loss of function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD). Progranulin is a secreted glycoprotein that localizes to lysosomes and is critical for proper lysosomal function. Heterozygous GRN
Externí odkaz:
https://doaj.org/article/a59bbbf5eb524493965514b250bd17c3
Autor:
Cristina L. Sánchez, Amanda E. D. Van Swearingen, Andrew E. Arrant, Caroline S. Biskup, Cynthia M. Kuhn, Florian D. Zepf
Publikováno v:
Food & Nutrition Research, Vol 59, Iss 0, Pp 1-10 (2015)
Background: Diet and nutrition can impact on the biological processes underpinning neuropsychiatric disorders. Amino acid (AA) mixtures lacking a specific neurotransmitter precursor can change the levels of brain serotonin (5-HT) or dopamine (DA) in
Externí odkaz:
https://doaj.org/article/72e540f1ab8f41f3b27bec92943d2add
Autor:
Skylar E. Davis, Anna K. Cook, Yuliya Voskobiynyk, Nancy VN Carullo, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A Pugh, Charles F Murchison, Laura J. McMeekin, Micah S. Simmons, Rita M. Cowell, Alissa Nana Li, Salvatore Spina, Lea Tenenholz Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
Publikováno v:
Alzheimer's & Dementia. 18