Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Andrew E Pollard"'
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104357 (2014)
Gap junctions (GJs) are the principal membrane structures that conduct electrical impulses between cardiac myocytes while interstitial collagen (IC) can physically separate adjacent myocytes and limit cell-cell communication. Emerging evidence sugges
Externí odkaz:
https://doaj.org/article/776cf4e9485a4e8d948a499810716609
Autor:
Saidulu Mattapally, Eric Zhang, Vladimir G Fast, Andrew E Pollard, Chandrakala Mattapally, Jianyi Zhang
Publikováno v:
Circulation. 144
Introduction: CRISPR editing of genomic regulatory elements with the intention of direct exon/intron splicing is a hopeful means of everlastingly alleviating genetic diseases. Cas9-induced DNA double-stranded break, non-homologous end-joining repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ed4b110ce457e66d8a43fcef10e1d4b
https://doi.org/10.1161/circ.144.suppl_1.13426
https://doi.org/10.1161/circ.144.suppl_1.13426
We have completed a range of membrane-based simulations of action potential propagation in two- and three-dimensional models of ventricular myocardium. The two-dimensional simulations included a bidomain representation of the myocardium which explici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4ff79487c9ace24bd6f6f5cd056200
https://doi.org/10.1201/9781003068136-17
https://doi.org/10.1201/9781003068136-17
Autor:
Andrew E. Pollard, Ramaswamy Kannappan, Asher Kahn-Krell, Vladimir G. Fast, Alan W. Eberhardt, Wesley C. LaBarge, Xi Lou, Danielle Pretorius, Jianyi Zhang, Joel L. Berry
Publikováno v:
Biomed Mater
Cardiac tissue surrogates show promise for restoring mechanical and electrical function in infarcted left ventricular (LV) myocardium. For these cardiac surrogates to be useful in vivo, they are required to support synchronous and forceful contractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0241cfa2979a84e51de89ca16ed66b06
https://pubmed.ncbi.nlm.nih.gov/33053512
https://pubmed.ncbi.nlm.nih.gov/33053512
Autor:
Andrew E. Pollard, Ramaswamy Kannappan, Saidulu Mattapally, Jianyi Zhang, Vladimir G. Fast, Ying Ge, Ling Gao, Anton V. Borovjagin, Gregory P. Walcott, Xinyang Hu, Wuqiang Zhu, Xi Lou, Zachery R. Gregorich, Steven G. Lloyd, Yasin Oduk
Publikováno v:
Circulation. 137:1712-1730
Background: Here, we generated human cardiac muscle patches (hCMPs) of clinically relevant dimensions (4 cm × 2 cm × 1.25 mm) by suspending cardiomyocytes, smooth muscle cells, and endothelial cells that had been differentiated from human induced-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841aa28951bf0edfc856e6cc0d251d24
https://doi.org/10.1161/circulationaha.117.030785
https://doi.org/10.1161/circulationaha.117.030785
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 306:H1660-H1668
This study was designed to test the hypothesis that a complex composite impedance spectra develops when stimulation and recording of cardiac muscle with sufficiently fine spatial resolution in a four-electrode configuration is used. With traditional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2862167a486f1f0f38bbfe5f7117cd
https://doi.org/10.1152/ajpheart.00661.2013
https://doi.org/10.1152/ajpheart.00661.2013
Publikováno v:
IEEE Transactions on Biomedical Engineering. 58:2120-2126
We developed a new method for ratiometric optical mapping of transmembrane potential (V(m)) in cardiac preparations stained with di-4-ANEPPS. V(m)-dependent shifts of excitation and emission spectra establish two excitation bands (481 and481 nm) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fc7e509aadacb44aa580bd44e4ed84
https://doi.org/10.1109/tbme.2011.2148719
https://doi.org/10.1109/tbme.2011.2148719
Publikováno v:
IEEE Reviews in Biomedical Engineering. 3:155-168
Bayesian interpretation of observations began in the early 1700s, and scientific electrophysiology began in the late 1700s. For two centuries these two fields developed mostly separately. In part that was because quantitative Bayesian interpretation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73791591f561a38449d82075e198d3c6
https://doi.org/10.1109/rbme.2010.2089375
https://doi.org/10.1109/rbme.2010.2089375
Publikováno v:
Cardiovascular Research. 73:101-110
Objectives: Responses of Ca i 2+ to electrical shocks are believed to be important in defibrillation but measurements of shock-induced Ca 2+ i changes during different phases of the action potential (AP) are lacking. The effects of shocks on Ca 2+ i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fa7374ef3eac9a5f74c6cdb6a866e9
https://doi.org/10.1016/j.cardiores.2006.10.028
https://doi.org/10.1016/j.cardiores.2006.10.028
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 453:871-877
Catecholamines are known to provoke cardiac arrhythmias, but important aspects such as localization of the arrhythmia source in multicellular tissue and exact ionic mechanisms are not well-known. In this work, a multicellular model of arrhythmias cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74ff83a6157c0850071652c91decfd1
https://doi.org/10.1007/s00424-006-0162-6
https://doi.org/10.1007/s00424-006-0162-6