Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew E O, Hughes"'
Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWhile tens of thousands of HLA alleles have been identified by DNA sequencing, the contribution of alternative splicing to HLA diversity is not well characterized. In this study, we sought to determine if long-read sequencing could be use
Externí odkaz:
https://doaj.org/article/17cffb73c6b64a13b5b7994fb83c165f
Autor:
Andrew E O Hughes, Vincent Magrini, Ryan Demeter, Christopher A Miller, Robert Fulton, Lucinda L Fulton, William C Eades, Kevin Elliott, Sharon Heath, Peter Westervelt, Li Ding, Donald F Conrad, Brian S White, Jin Shao, Daniel C Link, John F DiPersio, Elaine R Mardis, Richard K Wilson, Timothy J Ley, Matthew J Walter, Timothy A Graubert
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004462 (2014)
Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency of individual clones, their genetic composition, and their evolutionary relationships-w
Externí odkaz:
https://doaj.org/article/1777fa4a2cbc4a6098dfc41effa04000
Autor:
Andrew E O Hughes, Ronald Jackups
Publikováno v:
Clinical chemistry. 68(3)
Background As technology enables new and increasingly complex laboratory tests, test utilization presents a growing challenge for healthcare systems. Clinical decision support (CDS) refers to digital tools that present providers with clinically relev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6573f27248b612478fda4c3e022574
https://pubmed.ncbi.nlm.nih.gov/34871351
https://pubmed.ncbi.nlm.nih.gov/34871351
Autor:
Jacqueline E. Payton, Molly C Schroeder, Geoffrey L. Uy, Matthew J. Walter, Peter Westervelt, Andrew Bohannon, Julie Neidich, R. Wilson, Eric J. Duncavage, David H. Spencer, Scott Kruchowski, Michele O'Laughlin, John Garza, Robert S. Fulton, Matthew J. Christopher, Meagan A. Jacoby, Christopher A. Miller, Emma Hughes, Sharon Heath, John F. DiPersio, Andrew E. O. Hughes, Jack Baty, Daniel C. Link, Feiyu Du, Sandra MacMillan, Timothy J. Ley, Josh Robinson
Publikováno v:
N Engl J Med
BACKGROUND: Genomic analysis is essential for risk stratification in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a potential replacement for conventional cytogenetic and sequencing approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c3efa77ff65ee486184a5959962787
https://europepmc.org/articles/PMC8130455/
https://europepmc.org/articles/PMC8130455/
Autor:
Joseph C. Corbo, Leo Volkov, Vladimir J. Kefalov, Jeong Sook Kim-Han, Andrew E. O. Hughes, Deepak Poria, Lauren M. Saunders, David M. Parichy
Publikováno v:
Proc Natl Acad Sci U S A
Thyroid hormone (TH) signaling plays an important role in the regulation of long-wavelength vision in vertebrates. In the retina, thyroid hormone receptor β ( thrb ) is required for expression of long-wavelength-sensitive opsin ( lws ) in red cone p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04a16a9dcfba00ba7354af0b6f7fe00
https://pubmed.ncbi.nlm.nih.gov/34815349
https://pubmed.ncbi.nlm.nih.gov/34815349
Autor:
Neil W. Anderson, Meghan A. Wallace, Carey-Ann D. Burnham, Caitlin Johnson, Daniel M. Webber, Andrew E. O. Hughes
Publikováno v:
J Clin Microbiol
Multiplex PCR panels are powerful tools for rapid pathogen identification in patients with respiratory tract (RT) infections ([1][1][–][2][6][3]). In particular, analysis of upper respiratory tract (URT) specimens with the BioFire Respiratory Panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35a401813f84261dbb7f98ea94c4aff
https://doi.org/10.1128/jcm.00254-20
https://doi.org/10.1128/jcm.00254-20
Publikováno v:
Blood. 136:42-43
Human leukocyte antigen (HLA) typing plays a critical role in evaluating donor-recipient compatibility prior to hematopoietic cell transplantation (HCT) to minimize the risk of rejection and graft versus host disease (GVHD). Compared to traditional s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7cff5a881347d70ad2c5770b4b6463
https://doi.org/10.1182/blood-2020-140902
https://doi.org/10.1182/blood-2020-140902
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood. Here, we study a canonical pair of sister cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88555424f08293bf754fdddfe59163f1
https://doi.org/10.7554/elife.48216
https://doi.org/10.7554/elife.48216
Autor:
Carlos, Perez-Cervantes, Linsin A, Smith, Rangarajan D, Nadadur, Andrew E O, Hughes, Sui, Wang, Joseph C, Corbo, Constance, Cepko, Nicolas, Lonfat, Ivan P, Moskowitz
Publikováno v:
Development
Identification of cell type-specific cis-regulatory elements (CREs) is crucial for understanding development and disease, although identification of functional regulatory elements remains challenging. We hypothesized that context-specific CREs could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b04ef293ed00f29d3a5e450b3cce146
https://pubmed.ncbi.nlm.nih.gov/31915147
https://pubmed.ncbi.nlm.nih.gov/31915147