Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Andrew E, Jaffe"'
Autor:
Lionel A. Rodriguez, Matthew Nguyen Tran, Renee Garcia-Flores, Seyun Oh, Robert A. Phillips, Elizabeth A. Pattie, Heena R. Divecha, Sun Hong Kim, Joo Heon Shin, Yong Kyu Lee, Carly Montoya, Andrew E. Jaffe, Leonardo Collado-Torres, Stephanie C. Page, Keri Martinowich
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The lateral septum (LS), a GABAergic structure located in the basal forebrain, is implicated in social behavior, learning, and memory. We previously demonstrated that expression of tropomyosin kinase receptor B (TrkB) in LS neurons is requir
Externí odkaz:
https://doaj.org/article/8b1c03c8b1cb416194de52904abaf057
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Bisulfite sequencing is a powerful tool for profiling genomic methylation, an epigenetic modification critical in the understanding of cancer, psychiatric disorders, and many other conditions. Raw data generated by whole genome bi
Externí odkaz:
https://doaj.org/article/f2359397a2ee4f7d8e274040c222942d
Autor:
Vijay Sadashivaiah, Madhavi Tippani, Stephanie C. Page, Sang Ho Kwon, Svitlana V. Bach, Rahul A. Bharadwaj, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe, Kristen R. Maynard
Publikováno v:
BMC Neuroscience, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Multispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring multiple molecular signals in a single biological sample. Multiple fluorescent dyes, each me
Externí odkaz:
https://doaj.org/article/0dfa134e9c79402a844b850026892a27
Autor:
Madhavi Tippani, Elizabeth A. Pattie, Brittany A. Davis, Claudia V. Nguyen, Yanhong Wang, Srinidhi Rao Sripathy, Brady J. Maher, Keri Martinowich, Andrew E. Jaffe, Stephanie Cerceo Page
Publikováno v:
BMC Neuroscience, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Calcium imaging is a powerful technique for recording cellular activity across large populations of neurons. However, analysis methods capable of single-cell resolution in cultured neurons, especially for cultures derived from hum
Externí odkaz:
https://doaj.org/article/eb56475a8b4b4772b6ccf8c3a8d880ff
Autor:
Brenda Pardo, Abby Spangler, Lukas M. Weber, Stephanie C. Page, Stephanie C. Hicks, Andrew E. Jaffe, Keri Martinowich, Kristen R. Maynard, Leonardo Collado-Torres
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-5 (2022)
Abstract Background Spatially-resolved transcriptomics has now enabled the quantification of high-throughput and transcriptome-wide gene expression in intact tissue while also retaining the spatial coordinates. Incorporating the precise spatial mappi
Externí odkaz:
https://doaj.org/article/fd7c7cc7b496491490ee36657df60094
Autor:
Dylan C Sarver, Cheng Xu, Susana Rodriguez, Susan Aja, Andrew E Jaffe, Feng J Gao, Michael Delannoy, Muthu Periasamy, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H Reeves, G William Wong
Publikováno v:
eLife, Vol 12 (2023)
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism us
Externí odkaz:
https://doaj.org/article/3aeea4fdb24949308434aa922bedcafd
Autor:
Anthony D. Ramnauth, Kristen R. Maynard, Alisha S. Kardian, BaDoi N. Phan, Madhavi Tippani, Sumita Rajpurohit, John W. Hobbs, Stephanie Cerceo Page, Andrew E. Jaffe, Keri Martinowich
Publikováno v:
Brain Stimulation, Vol 15, Iss 2, Pp 427-433 (2022)
Background: Electroconvulsive therapy (ECT) efficacy is hypothesized to depend on induction of molecular and cellular events that trigger neuronal plasticity. Investigating how electroconvulsive seizures (ECS) impact plasticity in animal models can h
Externí odkaz:
https://doaj.org/article/14f862501964433caa632d20a3251f9d
Autor:
Dylan C. Sarver, Cheng Xu, Leandro M. Velez, Susan Aja, Andrew E. Jaffe, Marcus M. Seldin, Roger H. Reeves, G. William Wong
Publikováno v:
Molecular Metabolism, Vol 68, Iss , Pp 101666- (2023)
Objective: Trisomy 21 is one of the most complex genetic perturbations compatible with postnatal survival. Dosage imbalance arising from the triplication of genes on human chromosome 21 (Hsa21) affects multiple organ systems. Much of Down syndrome (D
Externí odkaz:
https://doaj.org/article/c0e401788b784ca4b4352f0e13a68cc8
Autor:
Madhavi Tippani, Heena R. Divecha, Joseph L. Catallini, Sang H. Kwon, Lukas M. Weber, Abby Spangler, Andrew E. Jaffe, Thomas M. Hyde, Joel E. Kleinman, Stephanie C. Hicks, Keri Martinowich, Leonardo Collado-Torres, Stephanie C. Page, Kristen R. Maynard
Publikováno v:
Biological Imaging, Vol 3 (2023)
Spatially resolved transcriptomics (SRT) is a growing field that links gene expression to anatomical context. SRT approaches that use next-generation sequencing (NGS) combine RNA sequencing with histological or fluorescent imaging to generate spatial
Externí odkaz:
https://doaj.org/article/7340b1102c004b1bb09838cdf6156fe8
Autor:
Christopher Wilks, Shijie C. Zheng, Feng Yong Chen, Rone Charles, Brad Solomon, Jonathan P. Ling, Eddie Luidy Imada, David Zhang, Lance Joseph, Jeffrey T. Leek, Andrew E. Jaffe, Abhinav Nellore, Leonardo Collado-Torres, Kasper D. Hansen, Ben Langmead
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-40 (2021)
Abstract We present recount3, a resource consisting of over 750,000 publicly available human and mouse RNA sequencing (RNA-seq) samples uniformly processed by our new Monorail analysis pipeline. To facilitate access to the data, we provide the recoun
Externí odkaz:
https://doaj.org/article/8ffd406a24644e9286dbf6b7448b3e96