Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andrew Douw"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The methylerythritol phosphate (MEP) pathway is responsible for biosynthesis of the precursors of isoprenoid compounds in eubacteria and plastids. It is a metabolic alternative to the well-known mevalonate pathway for isoprenoid production f
Externí odkaz:
https://doaj.org/article/bd68c10359be4db5a7197782ec6374a3
Autor:
Stefan Krco, Samuel J. Davis, Pallav Joshi, Liam A. Wilson, Marcelo Monteiro Pedroso, Andrew Douw, Christopher J. Schofield, Philip Hugenholtz, Gerhard Schenk, Marc T. Morris
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
β-Lactams are the most widely employed antibiotics in clinical settings due to their broad efficacy and low toxicity. However, since their first use in the 1940s, resistance to β-lactams has proliferated to the point where multi-drug resistant orga
Externí odkaz:
https://doaj.org/article/36419f8473744304b285ada2a5f77a80
Autor:
Marc T. Morris, Yonatan Mendels, Rozanne Stroek, Taeuk Kang, Gerhard Schenk, William Goracke, Alice Clark, Andrew Douw, Febe Vermue, Elaine B. Schenk, Stefan Krco, Maria C.R. Gutierrez, Liam A. Wilson, David García, Esmée Gianna Knaven, Marcelo Monteiro Pedroso, Nataša Mitić
Publikováno v:
Journal of Inorganic Biochemistry. 226:111637
Resistance to β-lactam antibiotics, including the “last-resort” carbapenems, has emerged as a major threat to global health. A major resistance mechanism employed by pathogens involves the use of metallo-β-lactamases (MBLs), zinc-dependent enzy