Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Andrew Dhawan"'
Autor:
Andrew Dhawan, Sarah Baitamouni, Darren Liu, Robyn Busch, Patricia Klaas, Thomas W. Frazier, Siddharth Srivastava, Sumit Parikh, Gary E. Hsich, Neil R. Friedman, David M. Ritter, Antonio Y. Hardan, Julian A. Martinez‐Agosto, Mustafa Sahin, Charis Eng
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 5, Pp 1301-1309 (2024)
Abstract Objective PTEN, a known tumor suppressor gene, is a mediator of neurodevelopment. Individuals with germline pathogenic variants in the PTEN gene, molecularly defined as PTEN hamartoma tumor syndrome (PHTS), experience a variety of neurologic
Externí odkaz:
https://doaj.org/article/e627e51a7036402a954a98ebc3dbbd28
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103357- (2024)
Summary: Circulating cell-free DNA (cfDNA) fragment end motif profiles are a promising biomarker in precision oncology. Here, we present a protocol for analyzing plasma cfDNA fragment end motifs from ultra-low-pass whole-genome sequencing (WGS) data.
Externí odkaz:
https://doaj.org/article/ade19bd103a34e02921660d0efc64d2c
Autor:
Jonathan Doan, Andrew Dhawan
Publikováno v:
The Journal of Climate Change and Health, Vol 16, Iss , Pp 100284- (2024)
Externí odkaz:
https://doaj.org/article/b103a16ba47049db876668b92b065104
Exploiting convergent phenotypes to derive a pan-cancer cisplatin response gene expression signature
Autor:
Jessica A. Scarborough, Steven A. Eschrich, Javier Torres-Roca, Andrew Dhawan, Jacob G. Scott
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-14 (2023)
Abstract Precision medicine offers remarkable potential for the treatment of cancer, but is largely focused on tumors that harbor actionable mutations. Gene expression signatures can expand the scope of precision medicine by predicting response to tr
Externí odkaz:
https://doaj.org/article/1ca297187c7d4b68a14cd53a0ddf872d
Publikováno v:
CNS Oncology, Vol 11, Iss 3 (2022)
We present two cases of von Hippel–Lindau (VHL) disease-associated hemangioblastomas in the CNS treated with the newly approved HIF-2α inhibitor, belzutifan. The first case is a 31-year-old female with confirmed pathogenic germline VHL mutation wh
Externí odkaz:
https://doaj.org/article/c06e4df12e6346cea01bb5e7edf62108
Autor:
Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, Daria Miroshnychenko, Diego Lozano-Peral, Bina Desai, Olena Balynska, Jan Poleszhuk, Liu Kenian, Mingxiang Teng, Mohamed Abazeed, Omar Mian, Aik Choon Tan, Eric Haura, Jacob Scott, Andriy Marusyk
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Acquired resistance to cancer therapies reflects the ability of cancers to adapt to therapy-imposed selective pressures. Here, the authors elucidate the dynamics of developing resistance to ALK inhibitors in an ALK+ lung cancer cell line showing that
Externí odkaz:
https://doaj.org/article/e895fc30a0004dd4847eaf04af82db31
Publikováno v:
Cancers, Vol 15, Iss 3, p 670 (2023)
Background: Glioblastoma mortality is driven by tumour progression or recurrence despite administering a therapeutic arsenal consisting of surgical resection, radiation, and alkylating chemotherapy. The genetic changes underlying tumour progression a
Externí odkaz:
https://doaj.org/article/0ceefc5b346747619559a44aeca2163e
Autor:
Davis T Weaver, Kathleen I Pishas, Drew Williamson, Jessica Scarborough, Stephen L Lessnick, Andrew Dhawan, Jacob G Scott
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008755 (2021)
MicroRNA (miRNA)-based therapies are an emerging class of targeted therapeutics with many potential applications. Ewing Sarcoma patients could benefit dramatically from personalized miRNA therapy due to inter-patient heterogeneity and a lack of drugg
Externí odkaz:
https://doaj.org/article/d3d3a5fa7c66497d85ed284850f43e42
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
miRNAs have emerged as regulators of diverse biological processes including cancer. Here the authors present an extended pan-cancer analysis of the miRNAs in 15 epithelial cancers; integrating methylation, transcriptomic and mutation data they reveal
Externí odkaz:
https://doaj.org/article/e52ce54346f6441bb9b0292d33a78d34
Autor:
Davis T Weaver, Benjamin D McElvany, Vishhvaan Gopalakrishnan, Kyle J Card, Dena Crozier, Andrew Dhawan, Mina N Dinh, Emily Dolson, Nathan Farrokhian, Masahiro Hitomi, Emily Ho, Tanush Jagdish, Eshan S King, Jennifer L Cadnum, Curtis J Donskey, Nikhil Krishnan, Gleb Kuzmin, Ju Li, Jeff Maltas, Jinhan Mo, Julia Pelesko, Jessica A Scarborough, Geoff Sedor, Enze Tian, Gary C An, Sean A Diehl, Jacob G Scott
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0241734 (2021)
Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease 2019 (COVID-19) increases exponentially in t
Externí odkaz:
https://doaj.org/article/c9cb9eb3a2b1444ea76753df9db95399