Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Andrew Dennis Wagner"'
Autor:
Timothy V Olah, Chang Liu, Jun Zhang, Thomas R. Covey, Harold N. Weller, Andrew Dennis Wagner, Wilson Z. Shou
Publikováno v:
Analytical Chemistry. 92:13525-13531
Bioanalysis of polar analytes using liquid chromatography-tandem mass spectrometry (LC-MS/MS) remains a significant challenge because of their poor chromatographic retention on the commonly used reversed-phase LC columns and the resulting severe ioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492780efe0ea7e7e1bd8560b5c3bfd3a
https://doi.org/10.1021/acs.analchem.0c03006
https://doi.org/10.1021/acs.analchem.0c03006
Autor:
Wilson Z. Shou, Lisa Elkin, Lizbeth Gallagher, Kathy Mosure, Matthew G. Soars, Andrew Dennis Wagner, Lindsey K. Stavola
Publikováno v:
Rapid Communications in Mass Spectrometry. 30:1787-1796
RATIONALE It is well known that the organic anion transporting polypeptide 1B1 (OATP1B1) plays a major role in the hepatic uptake of a range of drugs. To this end, it is pivotal that the potential for new molecular entities (NMEs) to inhibit OATP1B1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::086f44cd0c0c773cbf96346e4d975c32
https://doi.org/10.1002/rcm.7655
https://doi.org/10.1002/rcm.7655
Autor:
Dieter M. Drexler, Andrew Dennis Wagner, Zuzana Haarhoff, Pierre Picard, Tatyana Zvyaga, Wilson Z. Shou
Publikováno v:
SLAS Discovery. 21:165-175
The move toward label-free screening in drug discovery has increased the demand for mass spectrometry (MS)-based analysis. Here we investigated the approach of coupling acoustic sample deposition (ASD) with laser diode thermal desorption (LDTD)-tande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb762d7766b87527cef64c9626ae495
https://doi.org/10.1177/1087057115607184
https://doi.org/10.1177/1087057115607184
Autor:
Timothy V Olah, Tatyana Zvyaga, Janet Kolb, Harold N. Weller, John J. Herbst, Andrew Dennis Wagner, Can C. Özbal, Wilson Z. Shou
Publikováno v:
Rapid Communications in Mass Spectrometry. 25:1231-1240
The evaluation of interactions between drug candidates and transporters such as P-glycoprotein (P-gp) has gained considerable interest in drug discovery and development. Inhibition of P-gp can be assessed by performing bi-directional permeability stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8d38e09d7e74981224df680407e26f
https://doi.org/10.1002/rcm.4984
https://doi.org/10.1002/rcm.4984
Autor:
R. Burrell, A. D. Rodrigues, W. Turley, S. R. Johnson, J. E. Leet, Susan Jenkins, T. Philip, J. Hurley, Tatyana Zvyaga, Andrew Dennis Wagner
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 39(12)
In previous studies, gemfibrozil acyl-β-glucuronide, but not gemfibrozil, was found to be a mechanism-based inhibitor of cytochrome P450 2C8. To better understand whether this inhibition is specific for gemfibrozil acyl-β-glucuronide or whether oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9941166df1919b1a9677c6306bd2f5b4
https://pubmed.ncbi.nlm.nih.gov/21911547
https://pubmed.ncbi.nlm.nih.gov/21911547