Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Andrew D. Steele"'
Autor:
Song Meng, Andrew D. Steele, Wei Yan, Guohui Pan, Edward Kalkreuter, Yu-Chen Liu, Zhengren Xu, Ben Shen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Enzymes installing an intact hydropersulfide (-SSH) group into natural products have so far not been identified. Here, the authors report the characterization of an S-adenosyl methionine-dependent hydropersulfide methyltransferase (GnmP) for guangnan
Externí odkaz:
https://doaj.org/article/7e54d45513a14124aa34574274bcc283
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
The ability to tell time relative to predictable feeding opportunities has a long history of research, going back more than 100 years with behavioral observations of honeybees and rats. Animals that have access to food at a particular time of day exh
Externí odkaz:
https://doaj.org/article/b7e8e2063bae48e6ac9f200b77ae0754
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 16 (2022)
How dopamine signaling regulates biological rhythms is an area of emerging interest. Here we review experiments focused on delineating dopamine signaling in the suprachiasmatic nucleus, nucleus accumbens, and dorsal striatum to mediate a range of bio
Externí odkaz:
https://doaj.org/article/8fbf81c40a974c2490067464c56638e0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
A number of studies implicate biogenic amines in regulating circadian rhythms. In particular, dopamine and serotonin influence the entrainment of circadian rhythms to daily food availability. To study circadian entrainment to feeding, food availabili
Externí odkaz:
https://doaj.org/article/885288d5aa9a4a09ad8ecf7f9fa1b738
Autor:
Andrew D. Steele, Alexander F. Kiefer, Dobeen Hwang, Dong Yang, Christiana N. Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Publikováno v:
Journal of Medicinal Chemistry. 66:1562-1573
Antibody-drug conjugates (ADCs) are cancer chemotherapeutics that utilize a monoclonal antibody (mAb)-based delivery system, a cytotoxic payload, and a chemical linker. ADC payloads must be strategically functionalized to allow linker attachment with
Autor:
Xiao-wen Huang, Wen Pan, Mei-zhen Zhong, Yashpal Singh Chhonker, Andrew D. Steele, Colleen E. Keohane, Biswajit Mishra, Lewis Oscar Felix Raj Lucas, Daryl J. Murry, Frederick M. Ausubel, William M. Wuest, Chang-xing Li, Eleftherios Mylonakis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Acne vulgaris is a complex skin disease involving infection by Cutibacterium acnes , inflammation, and hyperkeratinization. We evaluated the activity of the retinoid 6-[3-(adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) and 16 other
Autor:
Firozeh Farahmand, Michael Sidikpramana, Bara Yousef, Sarah Sharif, Kieana Shao, Qijun Tang, Gina M. Leinninger, Ali D. Güler, Andrew D. Steele
The introduction of processed foods high in fat and sugars has caused a dramatic increase in obesity in humans. Diet-induced obesity (DIO) can be modeled in laboratory mice by increasing the fat content of their diet. Previously, it was determined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbc7f3ed3d9514fbb7f550ea99221edf
https://doi.org/10.1101/2022.06.27.497778
https://doi.org/10.1101/2022.06.27.497778
Publikováno v:
Journal of Biological Chemistry. 294:16567-16576
Throughout history, natural products have significantly contributed to the discovery of novel chemistry, drug leads, and tool molecules to probe and address complex challenges in biology and medicine. Recent microbial genome sequencing efforts have u
Autor:
Gabriel L. Hendricks, Kiho Lee, Xiaowen Huang, Taylor P. A. Hari, Jenna Port, Frederick M. Ausubel, Madeline M Dekarske, Noelly Queiroz Ribeiro, Hammad A. Faizi, Jake L Rosen, Andrew D. Steele, Wen Pan, Beth Burgwyn Fuchs, Guijin Zou, William M. Wuest, Eleftherios Mylonakis, Wenpeng Zhu, Nicolas Galle, Erika E Csatary, Petia M. Vlahovska, Huajian Gao, Ingrid K. Wilt, Katerina Tori, Wooseong Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 116:16529-16534
Treatment of Staphylococcus aureus infections is complicated by the development of antibiotic tolerance, a consequence of the ability of S. aureus to enter into a nongrowing, dormant state in which the organisms are referred to as persisters. We repo
Autor:
Wei Yan, Song Meng, Guohui Pan, Yu-Chen Liu, Andrew D. Steele, Zhengren Xu, Edward Kalkreuter, Ben Shen
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature forms S-S bonds by oxidizing two sulfhydryl groups, and no enzyme installing an intact hydropersulfide (-SSH) group into a natural product has been identified to date. The leinamycin (LNM) family of natural products features intact S-S bonds,