Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andrew D. Sheppard"'
Autor:
Maria Davern, Cillian O’ Donovan, Noel E. Donlon, Eimear Mylod, Caoimhe Gaughan, Anshul Bhardwaj, Andrew D. Sheppard, Dara Bracken-Clarke, Christine Butler, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 819 (2024)
The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve patient survival. This study
Externí odkaz:
https://doaj.org/article/3ca4eb6b6a0845a7a2adb872372af596
Autor:
Maria Davern, Caoimhe Gaughan, Fiona O’ Connell, Brendan Moran, Eimear Mylod, Andrew D. Sheppard, Sinead Ramjit, Jasmine Yun-Tong Kung, James J. Phelan, Matthew G. Davey, Eanna J. Ryan, Christine Butler, Laura Quinn, Claudine Howard, Emily Tone, Eimear Phoenix, Waqas T. Butt, Niamh Lynam-Lennon, Stephen G. Maher, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Noel E. Donlon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThis timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal canc
Externí odkaz:
https://doaj.org/article/e9a76b77fe4448bca0dc1485f4477ae2
Autor:
Maria Davern, Rebecca M. O’ Brien, Jason McGrath, Noel E. Donlon, Ashanty M. Melo, Croí E. Buckley, Andrew D. Sheppard, John V. Reynolds, Niamh Lynam-Lennon, Stephen G. Maher, Joanne Lysaght
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Chemotherapy upregulates immune checkpoint (IC) expression on the surface of tumour cells and IC-intrinsic signalling confers a survival advantage against chemotherapy in several cancer-types including oesophageal adenocarcinoma (OAC). Howev
Externí odkaz:
https://doaj.org/article/dc1658cc2c1c4f7893802d0bf5e392a0
Autor:
Maria Davern, Noel E. Donlon, Fiona O’ Connell, Andrew D. Sheppard, Conall Hayes, Ross King, Hugo Temperley, Christine Butler, Anshul Bhardwaj, Jenny Moore, Dara Bracken-Clarke, Claire Donohoe, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Melissa J. Conroy, Joanne Lysaght
Publikováno v:
Translational Oncology, Vol 20, Iss , Pp 101406- (2022)
Response rates to immune checkpoint blockade (ICB) remain low in oesophageal adenocarcinoma (OAC). Combining ICB with immunostimulatory chemotherapies to boost response rates is an attractive approach for converting ‘cold’ tumours into ‘hot’
Externí odkaz:
https://doaj.org/article/c52c824c793a4acdab0d58f23a41159d
Autor:
Maria Davern, Marie-Claire Fitzgerald, Croí E. Buckley, Aisling B. Heeran, Noel E. Donlon, Jason McGrath, Fiona O’ Connell, Malvika R. Deshpande, Conall Hayes, Jamie MacDonald, Andrew D. Sheppard, John V. Reynolds, Stephen G. Maher, Niamh Lynam-Lennon, Brona Murphy, Joanne Lysaght
Publikováno v:
Translational Oncology, Vol 19, Iss , Pp 101381- (2022)
Recent studies have demontrated that immune checkpoint receptors are expressed on the surface of oesophageal adenocarcinoma (OAC) cells and might confer a survival advantage. This study explores the role of PD-1 and TIGIT signalling in OAC cells in e
Externí odkaz:
https://doaj.org/article/96e5d6a96b624381831b60e85caffe2c
Autor:
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O’Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O’Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundImmune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic
Externí odkaz:
https://doaj.org/article/c1c43e80139b48f2bdb847aa34f8da63
Autor:
Maria Davern, Noel E. Donlon, Fiona O’Connell, Caoimhe Gaughan, Cillian O’Donovan, Mohammed Habash, Andrew D. Sheppard, Michael MacLean, Margaret R. Dunne, Jenny Moore, Hugo Temperley, Melissa J. Conroy, Christine Butler, Anshul Bhardwaj, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Cancer Immunology, Immunotherapy. 72:55-71
Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study investigated the effect of ac
Autor:
Maria Davern, Dara Bracken-Clarke, Noel E Donlon, Andrew D Sheppard, Fiona O connell, Aisling B Heeran, Klaudia Majcher, Melissa J Conroy, Eimear Mylod, Christine Butler, Claire Donohoe, Dearbhaile O' Donnell, Maevle Lowry, Anshul Bhardwaj, Narayanasamy Ravi, Ashanty A Melo, Jacintha O' Sullivan, John V Reynolds, Joanne Lysaght
Publikováno v:
Journal of Cancer Research and Clinical Oncology.
Aim Visceral obesity is a key risk factor in the development of oesophagogastric junctional adenocarcinoma (OGJ), predominantly via generation of systemic low grade inflammation. Obesity-induced inflammation promotes resistance to current standards o
Autor:
Maria, Davern, Noel E, Donlon, Fiona, O'Connell, Caoimhe, Gaughan, Cillian, O'Donovan, Jason, McGrath, Andrew D, Sheppard, Conall, Hayes, Ross, King, Hugo, Temperley, Michael, MacLean, Christine, Bulter, Anshul, Bhardwaj, Jenny, Moore, Claire, Donohoe, Narayanasamy, Ravi, Melissa J, Conroy, John V, Reynolds, Joanne, Lysaght
Publikováno v:
Journal of Cancer Research and Clinical Oncology.
Aim Use of immune checkpoint blockade to enhance T cell-mediated immunity within the hostile tumour microenvironment (TME) is an attractive approach in oesophageal adenocarcinoma (OAC). This study explored the effects of the hostile TME, including nu
Autor:
Maria davern, Noel E Donlon, Andrew D Sheppard, Fiona O' Connell, Klaudia D Majcher, Malika Grant, Aisling B. Heeran, Conall Hayes, Robert Farrell, Melissa J Conroy, Dermot O' Toole, Dara Bracken-Clarke, Emma Foley, Narayanasamy Ravi, Anshul Bhardwaj, John V. Reynolds, Stephen G. Maher, Jacintha O' Sullivan, Joanne Lysaght
Publikováno v:
Journal of Cancer Research and Clinical Oncology.
Background: Combining immunostimulatory chemotherapies with immunotherapy is an attractive strategy to enhance treatment responses in oesophagogastric junctional adenocarcinoma (OGJ). Methods: This study investigates the immunostimulatory properties