Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andrew D. Schutt"'
Autor:
Kang Le, Christophe Michoud, Robert T. Taylor, Christine Lukacs, Andrew D. Schutt, Lin Gao, Anthony Specian, Kenneth Carey Rupert, Stacy Remiszewski, Ann Polonskaia, Douglas Aguilar, Barry Goggin, John Anthony Moliterni, J. Heather Hogg, Liang Weiling, Xiaochun Han, Cheryl Janson, Louis J. Lombardo, Martin Weisel, Adrian J. Fretland, Steven Gregory Mischke, Norman Kong, Shirley Li, Robert Francis Kester, Andrew F. Donnell, Kyoungja Hong, Dave S. Solis, Karl Frank, Yan Lou
Publikováno v:
Journal of medicinal chemistry. 56(20)
XIAP is a key regulator of apoptosis, and its overexpression in cancer cells may contribute to their survival. The antiapoptotic function of XIAP derives from its BIR domains, which bind to and inhibit pro-apoptotic caspases. Most known IAP inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e48ef3b240f2787ad2fc864469665b6
https://pubmed.ncbi.nlm.nih.gov/24083782
https://pubmed.ncbi.nlm.nih.gov/24083782
Autor:
Ming-Chu Hsu, Douglas D. Richman, Mary Jane Potash, Lee W. Slice, David J. Volsky, Andrew D. Schutt, Maureen Holly, Michael I. Sherman
Publikováno v:
Science. 254:1799-1802
The human immunodeficiency virus-1 (HIV-1) trans-activator Tat is an attractive target for the development of antiviral drugs because inhibition of Tat would arrest the virus at an early stage. The drug Ro 5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798cc55517783cc401dd52ec3df87db2
https://doi.org/10.1126/science.1763331
https://doi.org/10.1126/science.1763331
Autor:
Andrew D. Schutt, Michael I. Sherman, Maureen Holly, Ming-Chu Hsu, David J. Volsky, Douglas D. Richman, Mary Jane Potash, Lee W. Slice
Publikováno v:
Biochemical Society transactions. 20(2)
Ro 5-3335, 7-chloro-5-(2-pyrryl)-3H-1,4-benzo-diazepin-2-(H)-one, has been shown to inhibit gene expression controlled by the human immunodeficiency virus-1 (HIV-1) LTR promoter. The inhibition was specific for the viral transcriptional transactivato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3211988fde1e4af1014b80010906771d
https://pubmed.ncbi.nlm.nih.gov/1397654
https://pubmed.ncbi.nlm.nih.gov/1397654