Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andrew D. Piekarz"'
Autor:
Andrew D. Piekarz, Daniel Ursu, Antoine Fouillet, Xiaofang Huang, Jake F. Watson, Baolin Li, Birgit T. Priest, Eric S. Nisenbaum, Emanuele Sher
Publikováno v:
Molecular Pain
Background The Nav1.7 subtype of voltage-gated sodium channels is specifically expressed in sensory and sympathetic ganglia neurons where it plays an important role in the generation and transmission of information related to pain sensation. Human lo
Autor:
Hanying Chen, Peilin Ma, Andy Hudmon, Andrew D. Piekarz, Weihua Song, Nicole M. Ashpole, Theodore R. Cummins, Yucheng Xiao, Weinian Shou
Publikováno v:
The Journal of Physiology. 590:5123-5139
Key points • We investigated how the F1486 deletion LQT3 mutation impairs the functional properties of the human cardiac voltage-gated sodium channel (hNav1.5) and alters action potential firing. • Voltage-clamp recordings from HEK 293 cells and
Autor:
May Khanna, Rajesh Khanna, Sarah M. Wilson, Matthew S. Ripsch, Nathan M. Hammes, Brian C Samuels, Joyce H. Hurley, Fletcher A. White, Carrie J. Ballard, Theodore R. Cummins, Joel M. Brittain, Andrew D. Piekarz
Publikováno v:
Channels. 5:449-456
The N-type voltage-gated calcium channel (Cav 2.2) has gained immense prominence in the treatment of chronic pain. While decreased channel function is ultimately anti-nociceptive, directly targeting the channel can lead to multiple adverse side effec
Publikováno v:
The Journal of Physiology. 589:597-608
Abnormal pain sensitivity associated with inherited and acquired pain disorders occurs through increased excitability of peripheral sensory neurons in part due to changes in the properties of voltage-gated sodium channels (Navs). Resurgent sodium cur
Publikováno v:
Journal of Clinical Investigation. 120:369-378
Inherited mutations in voltage-gated sodium channels (VGSCs; or Nav) cause many disorders of excitability, including epilepsy, chronic pain, myotonia, and cardiac arrhythmias. Understanding the functional consequences of the disease-causing mutations
Autor:
Theodore R. Cummins, Birgit T. Priest, Jeff S. McDermott, Eric S. Nisenbaum, Jeffrey L. Krajewski, Kelly L. Knopp, Andrew D. Piekarz, Zhi Yong Tan
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(21)
Resurgent sodium currents contribute to the regeneration of action potentials and enhanced neuronal excitability. Tetrodotoxin-sensitive (TTX-S) resurgent currents have been described in many different neuron populations, including cerebellar and dor
Autor:
Xiao Fang Yang, Yuying Wang, Christophe Salomé, Erik T. Dustrude, Cindy Barbosa, Harold Kohn, Sarah M. Wilson, Fletcher A. White, Michael R. Due, Rajesh Khanna, Andrew D. Piekarz, Theodore R. Cummins, Amber M. King
Publikováno v:
ACS chemical neuroscience. 3(12)
Four compounds that contained the N-benzyl 2-amino-3-methoxypropionamide unit were evaluated for their ability to modulate Na(+) currents in catecholamine A differentiated CAD neuronal cells. The compounds differed by the absence or presence of eithe
Publikováno v:
The Journal of physiology. 589(Pt 3)
Abnormal pain sensitivity associated with inherited and acquired pain disorders occurs through increased excitability of peripheral sensory neurons in part due to changes in the properties of voltage-gated sodium channels (Navs). Resurgent sodium cur
Autor:
Rajesh Khanna, Theodore R. Cummins, Joel M. Brittain, Takako Kondo, Yuying Wang, Andrew D. Piekarz
Collapsin response mediator proteins (CRMPs) specify axon/dendrite fate and axonal growth of neurons through protein-protein interactions. Their functions in presynaptic biology remain unknown. Here, we identify the presynaptic N-type Ca(2+) channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2705fb45cbe590cb750d96ebe032eb
https://europepmc.org/articles/PMC2781534/
https://europepmc.org/articles/PMC2781534/
Publikováno v:
Biophysical Journal. 96(3)
Voltage-gated sodium (Nav1.1-9) channels are dynamic transmembrane proteins that, in response to changes in the potential across the lipophilic cell membrane, undergo specific conformational (gating) modifications, between ion-conducting (open) and n