Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Andrew D. Hughes"'
Autor:
Quan Zhuang, Quan Liu, Sherrie J. Divito, Qiang Zeng, Karim M. Yatim, Andrew D. Hughes, Darling M. Rojas-Canales, A. Nakao, William J. Shufesky, Amanda L. Williams, Rishab Humar, Rosemary A. Hoffman, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Adrian E. Morelli
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.
Externí odkaz:
https://doaj.org/article/7df4dfdb27c84e1d8072441bd3894303
Autor:
Andrew D Hughes, Sarah K Tasian
Publikováno v:
The Hematologist. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ea5fac50ec5403b43e84927fb2d25d
https://doi.org/10.1182/hem.v20.3.2023310
https://doi.org/10.1182/hem.v20.3.2023310
Autor:
Peter Kurre, Andrew D Hughes
Publikováno v:
British Journal of Haematology. 196:274-287
Recent advances have facilitated studies of the clonal architecture of the aging haematopoietic system, and provided clues to the mechanisms underlying the origins of hematopoietic malignancy. Much less is known about the clonal composition of haemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a08cdd66dcd9ac18bf526cdc640f36
https://doi.org/10.1111/bjh.17653
https://doi.org/10.1111/bjh.17653
Autor:
Hehua Dai, Rayan Rammal, Douglas Landsittel, Daqiang Zhao, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Warren D. Shlomchik, Amanda L. Williams, Roger Tieu, Khodor I. Abou-Daya, Adrian E. Morelli, Andrew D. Hughes
Publikováno v:
Journal of Clinical Investigation. 130:287-294
Activation of host T cells that mediate allograft rejection is a 2-step process. The first occurs in secondary lymphoid organs where T cells encounter alloantigens presented by host DCs and differentiate to effectors. Antigen presentation at these si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea30308ebc669139db1febd863d92dc
https://doi.org/10.1172/jci125773
https://doi.org/10.1172/jci125773
Autor:
Yue Geng, Siddarth Chandrasekaran, Jong-Wei Hsu, Mishka Gidwani, Andrew D Hughes, Michael R King
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54959 (2013)
Hematogeneous metastasis can occur via a cascade of circulating tumor cell adhesion events to the endothelial lining of the vasculature, i.e. the metastatic cascade. Interestingly, the pro-inflammatory cytokines IL-6 and TNF-α, which play an importa
Externí odkaz:
https://doaj.org/article/4d25a26b12664c6cb0fe238d684d8291
Kidney transplantation is the treatment of choice for ESRD but is complicated by the response of the recipient's immune system to nonself histocompatibility antigens on the graft, resulting in rejection. Multiphoton intravital microscopy, referred to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ca7a6c8a808e186a497a838d1389f1
https://europepmc.org/articles/PMC6054351/
https://europepmc.org/articles/PMC6054351/
Selectin-mediated adhesion of circulating tumor cells (CTCs) to the endothelium is a critical step in cancer metastasis, a major factor contributing to the mortality of cancer. The formation of tethers between tumor cells and endothelial selectins in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d666507e2d5bd4891d62b7f013861a0
https://europepmc.org/articles/PMC6309786/
https://europepmc.org/articles/PMC6309786/
Autor:
Paul A. Heiney, Virgil Percec, Darrin J. Pochan, Annabelle Bertin, Andrew D. Hughes, Yingchao Chen, Ralph-Olivier Moussodia, Hao-Jan Sun, Shaodong Zhang, Michael L. Klein
Publikováno v:
Proceedings of the National Academy of Sciences. 111:9058-9063
A constitutional isomeric library synthesized by a modular approach has been used to discover six amphiphilic Janus dendrimer primary structures, which self-assemble into uniform onion-like vesicles with predictable dimensions and number of internal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636c786a5d69a4cdcaa5508797ad6f8e
https://doi.org/10.1073/pnas.1402858111
https://doi.org/10.1073/pnas.1402858111
Autor:
Adrian E. Morelli, Darling M. Rojas-Canales, Qiang Zeng, Karim M. Yatim, Quan Liu, William J. Shufesky, Warren D. Shlomchik, Andrew D. Hughes, Martin H. Oberbarnscheidt, Rosemary A. Hoffman, Fadi G. Lakkis, Rishab Humar, Quan Zhuang, Amanda L. Williams, Atsunori Nakao, Sherrie J. Divito
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
Successful engraftment of organ transplants has traditionally relied on preventing the activation of recipient (host) T cells. Once T-cell activation has occurred, however, stalling the rejection process becomes increasingly difficult, leading to gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae64b99907b11ae33ad39ab594e98ee9
https://doi.org/10.1038/ncomms12623
https://doi.org/10.1038/ncomms12623
Autor:
Michael R. King, Andrew D. Hughes, Bryan T. Greene, Jeff Mattison, Laura T. Western, John D. Powderly
Publikováno v:
Clinical Chemistry. 58:846-853
BACKGROUND Circulating tumor cells (CTCs) can be used clinically to treat cancer. As a diagnostic tool, the CTC count can be used to follow disease progression, and as a treatment tool, CTCs can be used to rapidly develop personalized therapeutic str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a4a5b3b032ec1e3a1e3b8f048c2d68
https://doi.org/10.1373/clinchem.2011.176669
https://doi.org/10.1373/clinchem.2011.176669