Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Andrew D. Hislop"'
Autor:
Robert Hollingworth, George L. Skalka, Grant S. Stewart, Andrew D. Hislop, David J. Blackbourn, Roger J. Grand
Publikováno v:
Viruses, Vol 7, Iss 6, Pp 2908-2927 (2015)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human malignancies. Human tumour viruses such as KSHV are known to interact with the DNA damage response (DDR), the molecular pathways that recognise and repair lesion
Externí odkaz:
https://doaj.org/article/bf274c40a8294e0e8cddb1ad49cc0055
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006042 (2016)
Kaposi sarcoma-associated herpesvirus (KSHV) is linked with the development of Kaposi sarcoma and the B lymphocyte disorders primary effusion lymphoma (PEL) and multi-centric Castleman disease. T cell immunity limits KSHV infection and disease, howev
Externí odkaz:
https://doaj.org/article/13260334cce64992933330fb7cf3e711
Autor:
Heng Giap Woon, Asolina Braun, Jane Li, Corey Smith, Jarem Edwards, Frederic Sierro, Carl G Feng, Rajiv Khanna, Michael Elliot, Andrew Bell, Andrew D Hislop, Stuart G Tangye, Alan B Rickinson, Thomas Gebhardt, Warwick J Britton, Umaimainthan Palendira
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005799 (2016)
Disruption of T cell memory during severe immune suppression results in reactivation of chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How different subsets of memory T cells contribute to the protective immunit
Externí odkaz:
https://doaj.org/article/552bcd3b75c8474db486435ca84dbb1b
Autor:
Qiliang Cai, Shuvomoy Banerjee, Amanda Cervini, Jie Lu, Andrew D Hislop, Richard Dzeng, Erle S Robertson
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003751 (2013)
Peptides presentation to T cells by MHC class II molecules is of importance in initiation of immune response to a pathogen. The level of MHC II expression directly influences T lymphocyte activation and is often targeted by various viruses. Kaposi's
Externí odkaz:
https://doaj.org/article/3849650e355c495a9aabdffc6e52a1be
Autor:
Jianmin Zuo, Wendy A Thomas, Tracey A Haigh, Leah Fitzsimmons, Heather M Long, Andrew D Hislop, Graham S Taylor, Martin Rowe
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002455 (2011)
Evasion of immune T cell responses is crucial for viruses to establish persistence in the infected host. Immune evasion mechanisms of Epstein-Barr virus (EBV) in the context of MHC-I antigen presentation have been well studied. In contrast, viral int
Externí odkaz:
https://doaj.org/article/6178491b1d0b40d1affd8e3e2c1c67a4
Autor:
Umaimainthan Palendira, Carol Low, Anna Chan, Andrew D Hislop, Edwin Ho, Tri Giang Phan, Elissa Deenick, Matthew C Cook, D Sean Riminton, Sharon Choo, Richard Loh, Frank Alvaro, Claire Booth, H Bobby Gaspar, Alessandro Moretta, Rajiv Khanna, Alan B Rickinson, Stuart G Tangye
Publikováno v:
PLoS Biology, Vol 9, Iss 11, p e1001187 (2011)
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite
Externí odkaz:
https://doaj.org/article/2f8dac67c92b469bb76a09f459caef5b
Publikováno v:
Access Microbiology. 1
Epstein-Barr virus (EBV) is one of 9 Human herpesviruses that can develop lifelong persistence. These viruses provide an antigenically complex challenge that induce strong CD8+T cell immunity during primary infection and continue to shape this immuni
Publikováno v:
Journal of Virology
Kaposi's sarcoma-associated herpesvirus (KSHV) has tropism for B lymphocytes, in which it establishes latency, and can also cause lymphoproliferative disorders of these cells manifesting as primary effusion lymphoma (PEL) and multicentric Castleman d
Publikováno v:
PLoS Pathogens
Human herpesviruses are antigenically rich agents that induce strong CD8+T cell responses in primary infection yet persist for life, continually challenging T cell memory through recurrent lytic replication and potentially influencing the spectrum of
Autor:
Alan B. Rickinson, Nick Tellam, Henry H. Balfour, Denis J. Moss, Michelle N. Wykes, Kristin A. Hogquist, Vijayendra Dasari, Rajiv Khanna, Corey Smith, Archana Panikkar, Andrew D. Hislop
Publikováno v:
Journal of Virology. 89:9137-9141
Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specifi