Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Andrew D. Grotzinger"'
Autor:
Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Hannah J. Gebhardt, Erik G. Willcutt, Andrew D. Grotzinger
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 3, Pp 100307- (2024)
Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with diagnostic criteria requiring symptoms to begin in childhood. We investigated whether individuals diagnosed as children differ from those diagnosed in a
Externí odkaz:
https://doaj.org/article/81edfddf25864d9cb385a0a2725b7753
Autor:
Andrew D. Grotzinger, Travis T. Mallard, Zhaowen Liu, Jakob Seidlitz, Tian Ge, Jordan W. Smoller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The current study identifies five genomic subclusters of brain regions for cortical thickness and surface area characterized by high levels of shared genetic signal. These subclusters map onto biological and functional parcellations of the cortex.
Externí odkaz:
https://doaj.org/article/558351e4e4a34c35ad3e76b038aa1876
Autor:
Andrew D. Grotzinger, Javier de la Fuente, Gail Davies, Michel G. Nivard, Elliot M. Tucker-Drob
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
High genetic overlap across traits requires methods that can be used to disentangle shared and unique biological pathways. Here, the authors introduce TSEM, a multivariate method for examining tissue-specific gene expression, and apply it to identify
Externí odkaz:
https://doaj.org/article/01eac78397864e54802d15cf51df6c99
Autor:
Cherry Youn, Andrew D. Grotzinger, Christina M. Lill, Lars Bertram, Florian Schmiedek, Martin Lövdén, Ulman Lindenberger, Michel Nivard, K. Paige Harden, Elliot M. Tucker-Drob
Publikováno v:
npj Science of Learning, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Cognitive performance is both heritable and sensitive to environmental inputs and sustained practice over time. However, it is currently unclear how genetic effects on cognitive performance change over the course of learning. We examine how
Externí odkaz:
https://doaj.org/article/68eccc9b93f84f6ba90aa46936c561d3
Autor:
Travis T. Mallard, Richard Karlsson Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, K. Paige Harden
Publikováno v:
Cell Genomics, Vol 2, Iss 6, Pp 100140- (2022)
Summary: Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensio
Externí odkaz:
https://doaj.org/article/e46aa5b1293c4d778b4c92cbacfead66
Publikováno v:
Physiological Reviews. 103:1645-1665
Genome-wide association studies (GWASs) have ushered in a new era of reproducible discovery in psychiatric genetics. The field has now identified hundreds of common genetic variants that are associated with mental disorders, and many of them influenc
Autor:
Andrew D. Grotzinger, Javier de la Fuente, Florian Privé, Michel G. Nivard, Elliot M. Tucker-Drob
Publikováno v:
Biological psychiatry, 93(1), 29-36. Elsevier USA
Grotzinger, A D, Fuente, J D L, Privé, F, Nivard, M G & Tucker-Drob, E M 2023, ' Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis : A Simple Solution ', Biological psychiatry, vol. 93, no. 1, pp. 29-36 . https://doi.org/10.1016/j.biopsych.2022.05.029
Grotzinger, A D, Fuente, J D L, Privé, F, Nivard, M G & Tucker-Drob, E M 2023, ' Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis : A Simple Solution ', Biological Psychiatry, vol. 93, no. 1, pp. 29-36 . https://doi.org/10.1016/j.biopsych.2022.05.029
Biol Psychiatry
Grotzinger, A D, Fuente, J D L, Privé, F, Nivard, M G & Tucker-Drob, E M 2023, ' Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis : A Simple Solution ', Biological psychiatry, vol. 93, no. 1, pp. 29-36 . https://doi.org/10.1016/j.biopsych.2022.05.029
Grotzinger, A D, Fuente, J D L, Privé, F, Nivard, M G & Tucker-Drob, E M 2023, ' Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis : A Simple Solution ', Biological Psychiatry, vol. 93, no. 1, pp. 29-36 . https://doi.org/10.1016/j.biopsych.2022.05.029
Biol Psychiatry
BACKGROUND: Single nucleotide polymorphism-based heritability is a fundamental quantity in the genetic analysis of complex traits. For case-control phenotypes, for which the continuous distribution of risk in the population is unobserved, observed-sc
Autor:
Laurel Raffington, Margherita Malanchini, Andrew D. Grotzinger, James W. Madole, Laura E. Engelhardt, Aditi Sabhlok, Cherry Youn, Megan W. Patterson, K. Paige Harden, Elliot M. Tucker-Drob
Publikováno v:
Developmental Psychology. 58:1832-1848
Dysregulation of biological stress response, as measured by cortisol output, has been a primary candidate mechanism for how social experiences become biologically embedded. Cortisol is the primary output of the hypothalamic pituitary adrenal (HPA) ax
Autor:
Katerina Zorina-Lichtenwalter, Carmen I. Bango, Lukas Van Oudenhove, Marta Čeko, Martin A. Lindquist, Andrew D. Grotzinger, Matthew C. Keller, Naomi P. Friedman, Tor D. Wager
Publikováno v:
Pain.
Autor:
Jeremy M. Lawrence, Sophie Breunig, Isabelle F. Foote, Connor B. Tallis, Andrew D. Grotzinger
BackgroundBipolar Disorder (BD) is an overarching diagnostic class defined by the presence of at least one prior manic episode (BD I) or both a prior hypomanic episode and a prior depressive episode (BD II). Traditionally, BD II has been conceptualiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d9b398fdc78c8b4fcbe40ab3e8a60c
https://doi.org/10.1101/2023.04.29.23289281
https://doi.org/10.1101/2023.04.29.23289281