The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)

Autor: Laura N. Verboon, Hiren C. Patel, Andrew D. Greenhalgh

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common form of TBI and affects millions of people each year. A history of mild TBI increases the risk of developing emotional and neurocognitive disorders later in l

Externí odkaz: https://doaj.org/article/1a7cdcc42c5046c8ab31ed91c0afe57c

Novel Influences of IL-10 on CNS Inflammation Revealed by Integrated Analyses of Cytokine Networks and Microglial Morphology

Autor: Warren D. Anderson, Andrew D. Greenhalgh, Aditya Takwale, Samuel David, Rajanikanth Vadigepalli

Publikováno v: Frontiers in Cellular Neuroscience, Vol 11 (2017)

Coordinated interactions between cytokine signaling and morphological dynamics of microglial cells regulate neuroinflammation in CNS injury and disease. We found that pro-inflammatory cytokine gene expression in vivo showed a pronounced recovery foll

Externí odkaz: https://doaj.org/article/96de2101807f4f5da98ac5689bc99525

Microglia states and nomenclature

Autor: Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C. Brown, Oleg Butovsky, Monica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimitrios Davalos, Philip L. De Jager, Bart de Strooper, Adam Denes, Bart J.L. Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K. Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta González, Siamon Gordon, Manuel B. Graeber, Andrew D. Greenhalgh, Pierre Gressens, Melanie Greter, David H. Gutmann, Christian Haass, Michael T. Heneka, Frank L. Heppner, Soyon Hong, David A. Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W. McColl, Veronique E. Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J. Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V. Hugh Perry, Phillip G. Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M. Ransohoff, Michael W. Salter, Anne Schaefer, Dorothy P. Schafer, Michal Schwartz, Mikael Simons, Cody J. Smith, Wolfgang J. Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valérie Wittamer, Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray

Publikováno v: Neuron
Neuron, vol 110, iss 21
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M-E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, de Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L-H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L-J & Wyss-Coray, T 2022, ' Microglia states and nomenclature : A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron 110(21), 3458-3483 (2022). doi:10.1016/j.neuron.2022.10.020
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, De Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L J & Wyss-Coray, T 2022, ' Microglia states and nomenclature: A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron, 2022, 110 (21), pp.3458-3483. ⟨10.1016/j.neuron.2022.10.020⟩

International audience; Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603341ba45a426c6d4f33e2cb8a2abc6
http://www.scopus.com/inward/record.url?scp=85140895591&partnerID=8YFLogxK

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Autor: Sol Beccari, Charlotte Madore, Amanda Sierra, Oleg Butovsky, Stéphane Grégoire, Pierre Gressens, Kanchan Bisht, V. De Smedt-Peyrusse, K.E. Hopperton, Lawrence Fourgeaud, Sophie Layé, Corinne Joffre, Richard P. Bazinet, Agnès Nadjar, Lionel Morel, C. Lacabanne, J. Bourel, A. Sere, Jean-Christophe Delpech, Lionel Bretillon, Andrew D. Greenhalgh, Aurore Thomazeau, Clémentine Bosch-Bouju, Agnès Aubert, Quentin Leyrolle, N. J. Grant, Cynthia Lecours, Marie-Ève Tremblay, J. Badaut

SUMMARYOmega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0975e7b0d0981d18c7e5557fdfd0d8c9
https://hal.archives-ouvertes.fr/hal-03339536/file/NutriNeuro_2019_Madore.pdf

Immune cell regulation of glia during CNS injury and disease

Autor: Samuel David, F. Chris Bennett, Andrew D. Greenhalgh

Publikováno v: Nature Reviews Neuroscience
Nature Reviews Neuroscience, Nature Publishing Group, 2020, 21 (3), pp.139-152. ⟨10.1038/s41583-020-0263-9⟩

International audience; Glial cells are abundant in the CNS and are essential for brain development and homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a possible contributing factor to neurodegenerative a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0b536221e899ee572bdcb1d65c339f
https://pubmed.ncbi.nlm.nih.gov/32042145