Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrew D. Fernandes"'
Publikováno v:
Austrian Journal of Statistics, Vol 45, Iss 4 (2016)
High throughput sequencing generates sparse compositional data, yet these datasets are rarely analyzed using a compositional approach. In addition, the variation inherent in these datasets is rarely acknowledged, but ignoring it can result in many fa
Externí odkaz:
https://doaj.org/article/5e98df9e430d4f488fb581543e918e2d
Publikováno v:
Evolutionary Bioinformatics, Vol 2, Pp 251-259 (2006)
We present computational methods and subroutines to compute Gaussian quadrature integration formulas for arbitrary positive measures. For expensive integrands that can be factored into well-known forms, Gaussian quadrature schemes allow for efficient
Externí odkaz:
https://doaj.org/article/e833322b005c426bb0e244aea05b8bd5
Publikováno v:
Evolutionary Bioinformatics, Vol 2 (2006)
We present computational methods and subroutines to compute Gaussian quadrature integration formulas for arbitrary positive measures. For expensive integrands that can be factored into well-known forms, Gaussian quadrature schemes allow for efficient
Externí odkaz:
https://doaj.org/article/c46d607de1ae4244a3eb96617b10eb31
Publikováno v:
Journal of Computational and Graphical Statistics. 25:971-979
Displaying the component-wise between-group differences high-dimensional datasets is problematic because widely used plots such as Bland–Altman and Volcano plots do not show what they are colloquially believed to show. Thus, it is difficult for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff81423e564a11461cdeb81f3b28bee
https://doi.org/10.1080/10618600.2015.1131161
https://doi.org/10.1080/10618600.2015.1131161
Publikováno v:
Nucleic Acids Research
Biochemistry Publications
Biochemistry Publications
Insight into protein structure and function is best obtained through a synthesis of experimental, structural and bioinformatic data. Here, we outline a framework that we call MUSE (mutual information, unigenic evolution and structure-guided elucidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c686a327562cfaba76eaea822ae982c9
https://doi.org/10.1093/nar/gkp1223
https://doi.org/10.1093/nar/gkp1223
Publikováno v:
Bioinformatics. 24:2177-2183
Motivation: In a nucleotide or amino acid sequence, not all sites evolve at the same rate, due to differing selective constraints at each site. Currently in computational molecular evolution, models incorporating rate heterogeneity always share two a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b35075f349b9d6ab5420268f58a1b1c
https://doi.org/10.1093/bioinformatics/btn395
https://doi.org/10.1093/bioinformatics/btn395
Autor:
Nicole Pinto, Anthony C. Nichols, Paul C. Boutros, Andrew D. Fernandes, Morgan Black, John W. Barrett, Benjamin Haibe-Kains, John Yoo
Publikováno v:
Oncology Publications
BMC pharmacology & toxicology, vol 15, iss 1
BMC Pharmacology & Toxicology
BMC pharmacology & toxicology, vol 15, iss 1
BMC Pharmacology & Toxicology
Background There is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput drug screening techniques and next-generation sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42da5a552ff42f50e64559018feadeb
https://ir.lib.uwo.ca/context/oncpub/article/1081/viewcontent/2050_6511_15_66.pdf
https://ir.lib.uwo.ca/context/oncpub/article/1081/viewcontent/2050_6511_15_66.pdf
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67019 (2013)
PLoS ONE
PLoS ONE
Experimental variance is a major challenge when dealing with high-throughput sequencing data. This variance has several sources: sampling replication, technical replication, variability within biological conditions, and variability between biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d2d9d6919009fb148de5475ff6403e
http://europepmc.org/articles/PMC3699591?pdf=render
http://europepmc.org/articles/PMC3699591?pdf=render
Autor:
Andrew D. Fernandes
Publikováno v:
Proceedings of the National Academy of Sciences. 109
In their recent contribution to PNAS, Fawcett and Higginson (1) analyzed article equation density with respect to citation rate. The observed negative correlation is used to conclude that “equation density has a strong negative impact on citation r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0f73cb41f8b73e77cb43ba7f19553f
https://doi.org/10.1073/pnas.1211892109
https://doi.org/10.1073/pnas.1211892109
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 8, p e23804 (2011)
PLoS ONE, Vol 6, Iss 8, p e23804 (2011)
Homing endonucleases are site-specific DNA endonucleases that function as mobile genetic elements by introducing double-strand breaks or nicks at defined locations. Of the major families of homing endonucleases, the modular GIY-YIG endonucleases are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f4e25d67b3dbf937b24bd89d157d6
http://europepmc.org/articles/PMC3161791
http://europepmc.org/articles/PMC3161791