Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Andrew D Simmons"'
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-6 (2020)
Abstract Background Poly (ADP-ribose) polymerase (PARP) inhibitors are approved for the treatment of breast cancer susceptibility genes 1 and 2 (BRCA1/2) mutant ovarian and breast cancers, and are now being evaluated in metastatic castration-resistan
Externí odkaz:
https://doaj.org/article/5b68b0f3762b440996950226d94ebb63
Autor:
Andrea Loehr, Arif Hussain, Akash Patnaik, Alan H. Bryce, Daniel Castellano, Albert Font, Jeremy Shapiro, Jingsong Zhang, Brieuc Sautois, Nicholas J. Vogelzang, Gurkamal Chatta, Kevin Courtney, Andrea Harzstark, Francesco Ricci, Darrin Despain, Simon Watkins, Charmin King, Minh Nguyen, Andrew D. Simmons, Simon Chowdhury, Wassim Abida
Publikováno v:
European Urology. 83:200-209
Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors are approved in the USA for the treatment of patients with BRCA1 or BRCA2 (BRCA) mutated (BRCA+) metastatic castration-resistant prostate cancer (mCRPC). BRCA reversion mutations are a k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eca73247f826498c75ed9682b7d31ae
https://doi.org/10.1016/j.eururo.2022.09.010
https://doi.org/10.1016/j.eururo.2022.09.010
Autor:
Liliane, Robillard, Mingxiang, Liao, Minh, Nguyen, Thomas C, Harding, Andrew D, Simmons, Rachel L, Dusek
Publikováno v:
Journal of Immunotherapy. 45:335-348
Lucitanib is a multi-tyrosine kinase inhibitor whose targets are associated with angiogenesis and other key cancer and immune pathways. Its antiangiogenic properties are understood, but lucitanib's immunomodulatory activity is heretofore unknown. Luc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b889b3648981c6d039cba99693f99c
https://doi.org/10.1097/cji.0000000000000427
https://doi.org/10.1097/cji.0000000000000427
Autor:
Dirk Zboralski, Frank Osterkamp, Esben Christensen, Anne Bredenbeck, Anne Schumann, Aileen Hoehne, Eberhard Schneider, Matthias Paschke, Jan Ungewiss, Christian Haase, Liliane Robillard, Andrew D. Simmons, Thomas C. Harding, Minh Nguyen
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging.
Purpose FAP is a membrane-bound protease under investigation as a pan-cancer target, given its high levels in tumors but limited expression in normal tissues. FAP-2286 is a radiopharmaceutical in clinical development for solid tumors that consists of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd4a37db504ea8cc30fd8827c34bb4f
https://doi.org/10.1007/s00259-023-06211-6
https://doi.org/10.1007/s00259-023-06211-6
Autor:
Andrew Allen, Thomas C. Harding, Andrew D. Simmons, Juswinder Singh, William Pao, Zoe Weaver, Jeff Etter, Terry Van Dyke, Mitch Raponi, Sarah Jaw-Tsai, Kevin Lin, William Westlin, Russell C. Petter, Mariana Nacht, Deqiang Niu, Prasoon Chaturvedi, Dan van Kalken, Russell Karp, Thia St Martin, Michael Sheets, Zhigang Wang, Zhendong Zhu, Matthew Labenski, Aleksandr Dubrovskiy, Kwangho Lee, Jing Sun, Kadoaki Ohashi, Henry J. Haringsma, Robert Tjin Tham Sjin, Annette O. Walter
Supplementary Figure 10 - PDF file 333K, Analysis of multiple EGFR-related signaling pathways in parental NCI-H1975 and COR resistant clones by Western blotting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02218769c548c4860660a91b6fa35b2e
https://doi.org/10.1158/2159-8290.22530312.v1
https://doi.org/10.1158/2159-8290.22530312.v1
Autor:
Andrew Allen, Thomas C. Harding, Andrew D. Simmons, Juswinder Singh, William Pao, Zoe Weaver, Jeff Etter, Terry Van Dyke, Mitch Raponi, Sarah Jaw-Tsai, Kevin Lin, William Westlin, Russell C. Petter, Mariana Nacht, Deqiang Niu, Prasoon Chaturvedi, Dan van Kalken, Russell Karp, Thia St Martin, Michael Sheets, Zhigang Wang, Zhendong Zhu, Matthew Labenski, Aleksandr Dubrovskiy, Kwangho Lee, Jing Sun, Kadoaki Ohashi, Henry J. Haringsma, Robert Tjin Tham Sjin, Annette O. Walter
Supplementary Figure 6 - PDF file 112K, Impact of CO-1686, erlotinib and afatinib administration on mouse body-weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb439fd0e027237f4641c54439c0817
https://doi.org/10.1158/2159-8290.22530294
https://doi.org/10.1158/2159-8290.22530294
Autor:
Andrew Allen, Thomas C. Harding, Andrew D. Simmons, Juswinder Singh, William Pao, Zoe Weaver, Jeff Etter, Terry Van Dyke, Mitch Raponi, Sarah Jaw-Tsai, Kevin Lin, William Westlin, Russell C. Petter, Mariana Nacht, Deqiang Niu, Prasoon Chaturvedi, Dan van Kalken, Russell Karp, Thia St Martin, Michael Sheets, Zhigang Wang, Zhendong Zhu, Matthew Labenski, Aleksandr Dubrovskiy, Kwangho Lee, Jing Sun, Kadoaki Ohashi, Henry J. Haringsma, Robert Tjin Tham Sjin, Annette O. Walter
Supplementary Figure 9 - PDF file 168K, NCI-H1975 parental and CO-1686 resistant clones cluster into distinct groups using an RNA-based EMT signature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aeaa7d1b613eaaf35d748e107d61faf
https://doi.org/10.1158/2159-8290.22530285.v1
https://doi.org/10.1158/2159-8290.22530285.v1
Autor:
Andrew Allen, Thomas C. Harding, Andrew D. Simmons, Juswinder Singh, William Pao, Zoe Weaver, Jeff Etter, Terry Van Dyke, Mitch Raponi, Sarah Jaw-Tsai, Kevin Lin, William Westlin, Russell C. Petter, Mariana Nacht, Deqiang Niu, Prasoon Chaturvedi, Dan van Kalken, Russell Karp, Thia St Martin, Michael Sheets, Zhigang Wang, Zhendong Zhu, Matthew Labenski, Aleksandr Dubrovskiy, Kwangho Lee, Jing Sun, Kadoaki Ohashi, Henry J. Haringsma, Robert Tjin Tham Sjin, Annette O. Walter
Supplementary Figure 3 - PDF file 295K, Activity of CO-1686 against rare lung-cancer associated EGFR mutants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75554071bcf856b9ed15932b3ea11f64
https://doi.org/10.1158/2159-8290.22530303
https://doi.org/10.1158/2159-8290.22530303
Autor:
Juswinder Singh, Andrew Allen, Russell C. Petter, William F. Westlin, Mariana Nacht, Deqiang Niu, Thomas C. Harding, Andrew D. Simmons, Mitch Raponi, Jeff Etter, Henry Haringsma, Yixuan Ren, Prasoon Chaturvedi, Aravind Medikonda, Russell Karp, Richland Tester, Zhendong Zhu, Matthew T. Labenski, Thia St. Martin, Michael Sheets, Aleksandr Dubrovskiy, Annette O. Walter, Kwangho Lee, Robert Tjin Tham Sjin
PDF - 252K, Supplemental Table 1. Mass spectrometry on EGFR-L858R/T790M protein. Supplemental Table 2. EGFR modulation in A431, H1975 and HCC827 cells by compound 3. Supplemental Table 3. Kinase selectivity profile of compound 3, afatinib and WZ4002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7affe8de12460b3179d7242aec74389b
https://doi.org/10.1158/1535-7163.22500919.v1
https://doi.org/10.1158/1535-7163.22500919.v1
Autor:
Andrew Allen, Thomas C. Harding, Andrew D. Simmons, Juswinder Singh, William Pao, Zoe Weaver, Jeff Etter, Terry Van Dyke, Mitch Raponi, Sarah Jaw-Tsai, Kevin Lin, William Westlin, Russell C. Petter, Mariana Nacht, Deqiang Niu, Prasoon Chaturvedi, Dan van Kalken, Russell Karp, Thia St Martin, Michael Sheets, Zhigang Wang, Zhendong Zhu, Matthew Labenski, Aleksandr Dubrovskiy, Kwangho Lee, Jing Sun, Kadoaki Ohashi, Henry J. Haringsma, Robert Tjin Tham Sjin, Annette O. Walter
Supplementary Table 1 - PDF file 114K, Kinase selectivity profiling of CO-1686
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a996a50c7f90ac2361cf9617ff1c04b
https://doi.org/10.1158/2159-8290.22530279
https://doi.org/10.1158/2159-8290.22530279