Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Andrew D Randall"'
Publikováno v:
eLife, Vol 9 (2020)
Dementia is associated with severe spatial memory deficits which arise from dysfunction in hippocampal and parahippocampal circuits. For spatially sensitive neurons, such as grid cells, to faithfully represent the environment these circuits require p
Externí odkaz:
https://doaj.org/article/71ee70328f8f4fac9d68cfea99aae63d
Autor:
Francesco eTamagnini, Janet eNovelia, Talitha L Kerrigan, Jon T Brown, Krasimira eTsaneva-Atanasova, Andrew D Randall
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain’s parenchyma and is a key histopathological hallmark of Alzheimer’s disease (AD). Work on transgenic mice that overexpress A suggests that elevated A
Externí odkaz:
https://doaj.org/article/55d5fd63ae6540109ae24505edbf1997
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92557 (2014)
Dimethylsulfoxide (DMSO) is a widely used solvent in biology. It has many applications perhaps the most common of which is in aiding the preparation of drug solutions from hydrophobic chemical entities. Recent studies have suggested that this molecul
Externí odkaz:
https://doaj.org/article/34271cb4a35246b7b9ebeb20c3dd35dd
Autor:
Milos M Petrovic, Jakub Nowacki, Valeria Olivo, Krasimira Tsaneva-Atanasova, Andrew D Randall, Jack R Mellor
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30402 (2012)
Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit both small conductance Ca(2+)-activated KCa2 pota
Externí odkaz:
https://doaj.org/article/e84ddbcd00654198b5f869fddbbf059a
Autor:
Erica S. Brady, Jessica Griffiths, Lilya Andrianova, Monika H. Bielska, Takashi Saito, Takaomi C. Saido, Andrew D. Randall, Francesco Tamagnini, Jonathan Witton, Michael T. Craig
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106151- (2023)
In the early stages of Alzheimer's disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disrupts neuronal activity, leading to the disruption of neuronal oscillations associated with cognition. This is thought to be lar
Externí odkaz:
https://doaj.org/article/9d519fa2f2764e72b12a5e04582bd6b0
Publikováno v:
Cells, Vol 11, Iss 21, p 3422 (2022)
Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced hypoglycaemia. This study examined the glutamate response of astrocytes when challenged with acute a
Externí odkaz:
https://doaj.org/article/29126711bddc4d2ab8c82c6d26c8075c
Autor:
Callum Walsh, Thomas Ridler, Gabriella Margetts-Smith, Maria Garcia Garrido, Jonathan Witton, Andrew D. Randall, Jonathan T. Brown
Publikováno v:
J Neurosci
The retrosplenial cortex (RSC) plays a significant role in spatial learning and memory and is functionally disrupted in the early stages of Alzheimer's disease (AD). In order to investigate neurophysiological correlates of spatial learning and memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316ddd98fece249ef82d018da38f300e
https://doi.org/10.1523/jneurosci.0890-21.2022
https://doi.org/10.1523/jneurosci.0890-21.2022
Autor:
Piotr Grabowski, Jonathan S. Ball, Joseph Pinion, Andrew D. Randall, Jeremy Metz, Will S. Redfern, Malcolm J. Hetheridge, Marc Goodfellow, Matthew J. Winter, Charles R. Tyler, Karen Tse, Aya Takesono, Anna Tochwin, Maciej Trznadel
Publikováno v:
British Journal of Pharmacology. 178:2671-2689
BACKGROUND AND PURPOSE Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f7ff4230befba435c0d0b1c1ff643e
https://doi.org/10.1111/bph.15458
https://doi.org/10.1111/bph.15458
Autor:
Erica S Brady, Jessica Griffiths, Lilya Andrianova, Takashi Saito, Takaomi C Saido, Andrew D Randall, Francesco Tamagnini, Jonathan Witton, Michael T Craig
In the early stages of Alzheimer’s disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disrupts neuronal activity and leads to disruption of neuronal oscillations associated with cognition. This is thought to be larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f78944c32bd995413cac46f2bb3f8f0
https://doi.org/10.1101/2022.02.08.479119
https://doi.org/10.1101/2022.02.08.479119
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344a5f606929af56810b013d43bc7aa5
https://doi.org/10.1530/endoabs.77.p182
https://doi.org/10.1530/endoabs.77.p182