Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Andrew D Randall"'
Autor:
Erica S. Brady, Jessica Griffiths, Lilya Andrianova, Monika H. Bielska, Takashi Saito, Takaomi C. Saido, Andrew D. Randall, Francesco Tamagnini, Jonathan Witton, Michael T. Craig
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106151- (2023)
In the early stages of Alzheimer's disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disrupts neuronal activity, leading to the disruption of neuronal oscillations associated with cognition. This is thought to be lar
Externí odkaz:
https://doaj.org/article/9d519fa2f2764e72b12a5e04582bd6b0
Publikováno v:
Cells, Vol 11, Iss 21, p 3422 (2022)
Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced hypoglycaemia. This study examined the glutamate response of astrocytes when challenged with acute a
Externí odkaz:
https://doaj.org/article/29126711bddc4d2ab8c82c6d26c8075c
Publikováno v:
eLife, Vol 9 (2020)
Dementia is associated with severe spatial memory deficits which arise from dysfunction in hippocampal and parahippocampal circuits. For spatially sensitive neurons, such as grid cells, to faithfully represent the environment these circuits require p
Externí odkaz:
https://doaj.org/article/71ee70328f8f4fac9d68cfea99aae63d
Autor:
Johanna S. Jackson, Jonathan Witton, James D. Johnson, Zeshan Ahmed, Mark Ward, Andrew D. Randall, Michael L. Hutton, John T. Isaac, Michael J. O’Neill, Michael C. Ashby
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3063-3068 (2017)
Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal bouto
Externí odkaz:
https://doaj.org/article/c8d1c1bd56734a5daf6d3a26936978f0
Autor:
Callum Walsh, Thomas Ridler, Gabriella Margetts-Smith, Maria Garcia Garrido, Jonathan Witton, Andrew D. Randall, Jonathan T. Brown
Publikováno v:
J Neurosci
The retrosplenial cortex (RSC) plays a significant role in spatial learning and memory and is functionally disrupted in the early stages of Alzheimer's disease (AD). In order to investigate neurophysiological correlates of spatial learning and memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316ddd98fece249ef82d018da38f300e
https://doi.org/10.1523/jneurosci.0890-21.2022
https://doi.org/10.1523/jneurosci.0890-21.2022
Publikováno v:
Neurobiology of Stress, Vol 10, Iss , Pp - (2019)
The bed nucleus of the stria terminalis (BNST) is a sexually dimorphic brain region which plays a key role in stress, anxiety, and anxiety-related disorders. Human females have an increased susceptibility to anxiety-related disorders, however the phy
Externí odkaz:
https://doaj.org/article/ffbf6641a89446deb332d5306b82cf73
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Intrinsic neuronal excitability has been reported to change during normal aging. The bed nucleus of the stria terminalis (BNST), a limbic forebrain structure, is involved in fear, stress and anxiety; behavioral features that exhibit age-dependent pro
Externí odkaz:
https://doaj.org/article/602157103b3147c9a8571ab69a921f98
Autor:
Piotr Grabowski, Jonathan S. Ball, Joseph Pinion, Andrew D. Randall, Jeremy Metz, Will S. Redfern, Malcolm J. Hetheridge, Marc Goodfellow, Matthew J. Winter, Charles R. Tyler, Karen Tse, Aya Takesono, Anna Tochwin, Maciej Trznadel
Publikováno v:
British Journal of Pharmacology. 178:2671-2689
BACKGROUND AND PURPOSE Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f7ff4230befba435c0d0b1c1ff643e
https://doi.org/10.1111/bph.15458
https://doi.org/10.1111/bph.15458
Autor:
Erica S Brady, Jessica Griffiths, Lilya Andrianova, Takashi Saito, Takaomi C Saido, Andrew D Randall, Francesco Tamagnini, Jonathan Witton, Michael T Craig
In the early stages of Alzheimer’s disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disrupts neuronal activity and leads to disruption of neuronal oscillations associated with cognition. This is thought to be larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f78944c32bd995413cac46f2bb3f8f0
https://doi.org/10.1101/2022.02.08.479119
https://doi.org/10.1101/2022.02.08.479119
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344a5f606929af56810b013d43bc7aa5
https://doi.org/10.1530/endoabs.77.p182
https://doi.org/10.1530/endoabs.77.p182