Zobrazeno 1 - 10
of 422
pro vyhledávání: '"Andrew D McCulloch"'
Autor:
Jason Z Zhang, Andy H Nguyen, Shigeki Miyamoto, Joan Heller Brown, Andrew D McCulloch, Jin Zhang
Publikováno v:
PLoS Biology, Vol 18, Iss 9, p e3000866 (2020)
The small GTPase RhoA is a central signaling enzyme that is involved in various cellular processes such as cytoskeletal dynamics, transcription, and cell cycle progression. Many signal transduction pathways activate RhoA-for instance, Gαq-coupled Hi
Externí odkaz:
https://doaj.org/article/0ebb54bacf2e4652ac3dc47d3752c53f
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241390 (2020)
Mechanical cues activate cardiac fibroblasts and induce differentiation into myofibroblasts, which are key steps for development of cardiac fibrosis. In vitro, the high stiffness of plastic culturing conditions will also induce these changes. It is t
Externí odkaz:
https://doaj.org/article/ee0d66ff64104314b4550c72ae8f7d91
Autor:
Pei-Chi Yang, Shweta Purawat, Pek U Ieong, Mao-Tsuen Jeng, Kevin R DeMarco, Igor Vorobyov, Andrew D McCulloch, Ilkay Altintas, Rommie E Amaro, Colleen E Clancy
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 3, p e1006856 (2019)
Multi-scale computational modeling is a major branch of computational biology as evidenced by the US federal interagency Multi-Scale Modeling Consortium and major international projects. It invariably involves specific and detailed sequences of data
Externí odkaz:
https://doaj.org/article/a9798631d43e4238936e418a85225114
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 11, p e1005854 (2017)
Mechanical strain is a potent stimulus for growth and remodeling in cells. Although many pathways have been implicated in stretch-induced remodeling, the control structures by which signals from distinct mechano-sensors are integrated to modulate hyp
Externí odkaz:
https://doaj.org/article/857c1594eb024056bab3e833cab31e86
Autor:
Pei-Chi Yang, Britton W Boras, Mao-Tsuen Jeng, Steffen S Docken, Timothy J Lewis, Andrew D McCulloch, Robert D Harvey, Colleen E Clancy
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 7, p e1005005 (2016)
Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has remained a mystery for more
Externí odkaz:
https://doaj.org/article/773b99d8f5d04386a4cbea3f0e8ec881
Publikováno v:
Molecular Systems Biology, Vol 4, Iss 1, Pp 1-13 (2008)
Abstract The fruitfly Drosophila melanogaster is increasingly used as a model organism for studying acute hypoxia tolerance and for studying aging, but the interactions between these two factors are not well known. Here we show that hypoxia tolerance
Externí odkaz:
https://doaj.org/article/fb0315cf00d3457eb9bffa98c20565d2
Autor:
Sophia P Hirakis, Britton Warren Boras, Lane W Votapka, Robert Dean Malmstrom, Andrew D McCulloch, Rommie E Amaro
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
The goal of multiscale modeling in biology is to use structurally based physico-chemical models to integrate across temporal and spatial scales of biology and thereby improve mechanistic understanding of, for example, how a single mutation can alter
Externí odkaz:
https://doaj.org/article/0fb01e8cf24d4f469d2801a68478530b
Autor:
Kevin P Vincent, Matthew J Gonzales, Andrew K Gillette, Christopher T Villongco, Simone ePezzuto, Jeffrey H Omens, Michael J Holst, Andrew D McCulloch
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Computational modeling of tissue-scale cardiac electrophysiology requires numerically converged solutions to avoid spurious artifacts. The steep gradients inherent to cardiac action potential propagation necessitate fine spatial scales and therefore
Externí odkaz:
https://doaj.org/article/86046bbb4b1a434f87b6e5647d6af788
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
CaMKII activity has been shown to contribute to arrhythmogenesis in a remarkably broad range of cardiac pathologies. Several of these involve significant structural and electrophysiologic remodeling, whereas others are due to specific channelopathies
Externí odkaz:
https://doaj.org/article/5f64dc9555d5448a8775a3cc0e84fcdd
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Calcium plays a crucial role in excitation-contraction coupling (ECC), but it is also a pivotal second messenger activating Ca2+-dependent transcription factors in a process termed excitation-transcription coupling (ETC). Evidence accumulated over th
Externí odkaz:
https://doaj.org/article/4ba7a5b4a1194ab9a00820fecc1e221d