Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Andrew D McAinsh"'
Autor:
Peter A Embacher, Tsvetelina E Germanova, Emanuele Roscioli, Andrew D McAinsh, Nigel J Burroughs
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010765 (2022)
Gaussian spot fitting methods have significantly extended the spatial range where fluorescent microscopy can be used, with recent techniques approaching nanometre (nm) resolutions. However, small inter-fluorophore distances are systematically over-es
Externí odkaz:
https://doaj.org/article/911f5eba65ac492a9901c38a7287b687
Publikováno v:
eLife, Vol 5 (2016)
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine. Connections to this spindle are mediated by sister kinetochore pairs, that form dynamic end-on atta
Externí odkaz:
https://doaj.org/article/7f9e32147648475e99dd8d9914993c1e
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 11, p e1004607 (2015)
Kinetochores are multi-protein complexes that mediate the physical coupling of sister chromatids to spindle microtubule bundles (called kinetochore (K)-fibres) from respective poles. These kinetochore-attached K-fibres generate pushing and pulling fo
Externí odkaz:
https://doaj.org/article/91035537a0d249fc8b9d51c36d375eab
Publikováno v:
eLife, Vol 4 (2015)
The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated sister kinetochores. Sister kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin. A crucial
Externí odkaz:
https://doaj.org/article/735adec1eb15452db5359900ce804058
Publikováno v:
eLife, Vol 3 (2014)
Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement. In this study, we reconstitute full-length hKif15 and its microtubule-targeting factor hT
Externí odkaz:
https://doaj.org/article/78ad08d1141a4c6ab34c180262524e98
Autor:
Anja Eskat, Wen Deng, Antje Hofmeister, Sven Rudolphi, Stephan Emmerth, Daniela Hellwig, Tobias Ulbricht, Volker Döring, James M Bancroft, Andrew D McAinsh, M Cristina Cardoso, Patrick Meraldi, Christian Hoischen, Heinrich Leonhardt, Stephan Diekmann
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44717 (2012)
Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process. The initi
Externí odkaz:
https://doaj.org/article/8ed63ac13a1540678c3a656df8c11a91
Autor:
Marcin R Przewloka, Wei Zhang, Patricia Costa, Vincent Archambault, Pier Paolo D'Avino, Kathryn S Lilley, Ernest D Laue, Andrew D McAinsh, David M Glover
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e478 (2007)
BackgroundKinetochores are large multiprotein complexes indispensable for proper chromosome segregation. Although Drosophila is a classical model organism for studies of chromosome segregation, little is known about the organization of its kinetochor
Externí odkaz:
https://doaj.org/article/ce68a920a71e4ab6a35b6c9ba0b24216
Autor:
Cédric Castrogiovanni, Alessio V. Inchingolo, Jonathan U. Harrison, Damian Dudka, Onur Sen, Nigel J. Burroughs, Andrew D. McAinsh, Patrick Meraldi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microtubules are built from GDP-tubulin lattices with small GTP caps at their plus-ends. Here, the authors reveal that microtubules that attach to kinetochores in mitosis contain, in addition to the GTP-cap and the GDP-lattices, a dynamic micron-size
Externí odkaz:
https://doaj.org/article/7374639fc1bf4c5e9e3d04d7bba621f4
Autor:
Emanuele Roscioli, Tsvetelina E. Germanova, Christopher A. Smith, Peter A. Embacher, Muriel Erent, Amelia I. Thompson, Nigel J. Burroughs, Andrew D. McAinsh
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp - (2020)
Summary: Kinetochores are multi-protein machines that form dynamic attachments to microtubules and control chromosome segregation. High fidelity is ensured because kinetochores can monitor attachment status and tension, using this information to acti
Externí odkaz:
https://doaj.org/article/786ffb97659f4948ad237de50c3a4a33
Autor:
Andrew D. McAinsh, Adele L. Marston
Publikováno v:
Mcainsh, A D & Marston, A L 2022, ' The four causes : The functional architecture of centromeres and kinetochores ', Annual review of genetics, vol. 56, no. 1, pp. 279-314 . https://doi.org/10.1146/annurev-genet-072820-034559
Kinetochores are molecular machines that power chromosome segregation during the mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have knowledge of a thing only when we have grasped its cause. In our case, to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e8f4f00b6a230fa6af5493fb78b4a2
https://doi.org/10.1146/annurev-genet-072820-034559
https://doi.org/10.1146/annurev-genet-072820-034559